不同尼古丁替代療法與六個月戒菸成功相關之實施研究

Chun-Ying Chen; Jia-Ling Wu; Shang-Chi Lee; Chin-Wei Kuo; Chuan-Yu Chen; Esther Ching-Lan Lin; Chung-Yi Li

doi:10.6288/TJPH.202412_43(6).113069

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P607 - 618

医药卫生 > 预防保健与卫生学
医药卫生 > 社会医学

DOI： 10.6288/TJPH

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不同尼古丁替代疗法与六个月戒菸成功相关之实施研究

Association between different nicotine replacement therapy regimens and 6-month smoking cessation success: an implementation study

陈骏莹(Chun-Ying Chen) ；吴嘉玲(Jia-Ling Wu) ；李商琪(Shang-Chi Lee) ；郭钧玮(Chin-Wei Kuo) ；陈全裕(Chuan-Yu Chen) ；林静兰(Esther Ching-Lan Lin) ；李中一(Chung-Yi Li)

台湾公共卫生杂志； 43 卷 6 期 (2024 / 12 / 23) ， P607 - 618

繁体中文;英文 DOI： 10.6288/TJPH.202412_43(6).113069

戒菸计画；尼古丁替代疗法；戒菸治疗； smoking cessation program ； nicotine replacement therapy ； smoking cessation treatment

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摘要 │ 参考文献 (27)

摘要〈TOP〉

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Objectives: To conduct an implementation study by using data from Taiwan's Second Generation Smoking Cessation Service to explore the associations between different nicotine replacement therapy (NRT) regimens and smoking cessation success in the real world. Methods: Data on initial NRT treatment sessions from January 1, 2020, to June 30, 2022, were included. Propensity score matching was applied to obtain a 1:1:1 sample. The exposure variables were three NRT types: long-acting NRT alone, short-acting NRT alone, and combined long-acting and short-acting NRT. The outcome variable was smoking cessation at the 6-month mark. Logistic regression was performed using generalized estimation equations. Results: A total of 26,604 NRT treatment sessions were included. The 6-month cessation prevalence was 19.86%. After adjustment for potential confounders, short-acting NRT alone (odds ratio [OR] = 1.16, 95% confidence interval [CI]: 1.07-1.25) and combined NRT (OR = 1.21, 95% CI: 1.12-1.31) were both associated with higher odds of cessation success when compared with long-acting NRT alone. However, the short-acting oral inhaler did not reach statistical significance (OR = 1.03, 95% CI: 0.85-1.25). A significant interaction was detected between age and NRT type; compared with long-acting NRT alone, short-acting NRT alone and combined NRT were more effective in users aged 18-44. Conclusions: The finding that combined NRT is more effective than long-acting NRT alone is consistent with the results of previous randomized controlled trials. However, this study also revealed that short-acting NRT alone is more effective than long-acting NRT alone, particularly among users aged 18-44 years. This work was funded by the Health Promotion Administration, Ministry of Health and Welfare. The content of this research may not represent the opinion of the Health Promotion Administration, Ministry of Health and Welfare.

参考文献 ( 27 ) 〈TOP〉

Brownson, RC(ed.),Colditz, GA(ed.),Proctor, EK(ed.)(2012).Dissemination and Implementation Research in Health: Translating Science to Practice.New York, NY:Oxford University Press.
Caponnetto, P,Polosa, R(2008).Common predictors of smoking cessation in clinical practice.Respir Med,102,1182-1192.
Chang, PY,Shiu, MN,Yuan, YT,Chang, HC,Su, PY,Lan, TH(2019).Comparative effectiveness of varenicline and nicotine replacement therapy for smoking cessation in older and younger smokers: a prospective cohort in Taiwan.Nicotine Tob Res,21,149-155.
Cohen-Mansfield, J(2016).Predictors of smoking cessation in old-old age.Nicotine Tob Res,18,1675-1679.
Fagerström, K(2012).Determinants of tobacco use and renaming the FTND to the Fagerstrom Test for Cigarette Dependence.Nicotine Tob Res,14,75-78.

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