The Effects of Plantago major on the Activation of the Neutrophil Respiratory Burst

Elaine Reina; Nouf Al-Shibani; Eman Allam; Karen S. Gregson; Michael Kowolik; L. Jack Windsor

doi:10.4103/2225-4110.119706

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P268 - 272

医药卫生 > 中医药学

DOI： 10.1016/j.jtcme

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The Effects of Plantago major on the Activation of the Neutrophil Respiratory Burst

Elaine Reina ； Nouf Al-Shibani ； Eman Allam ； Karen S. Gregson ； Michael Kowolik ； L. Jack Windsor

Journal of Traditional and Complementary Medicine ； 3 卷 4 期 (2013 / 10 / 01) ， P268 - 272

英文 DOI： 10.4103/2225-4110.119706

Aucubin ； Baicalein ； Neutrophil respiratory burst activity ； Plantago major

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摘要 │ 参考文献 (24) │ 被引用文献 (1) │ 国际计量

摘要〈TOP〉

Plantago major is a common plant that grows worldwide in temperate zones and is found in fields, lawns, and on the roadsides. Its leaves and seeds have been used in almost all parts of the world for centuries as a wound healer, analgesic, antioxidant, and antibiotic, as well as an immune system modulator, antiviral, antifungal, and anti-inflammatory agent. Baicalein and aucubin are the two most biologically active components of P. major, and both have been shown to have antioxidant, anti-inflammatory, and anticancer properties. Neutrophils have a pivotal role in wound healing and inflammation. Their principal mechanism of host defense is the killing of pathogens via the production of reactive oxygen species (ROS). The aim of the present study was to determine the in vitro effects of P. major extract, baicalein, and aucubin on human neutrophil respiratory burst activity. The cytotoxicity of the agents was assessed by lactate dehydrogenase (LDH) assays. A standard luminol-dependent chemiluminescence (CL) assay was utilized to monitor the respiratory burst of the neutrophils after exposure to P. major extract and its two active ingredients, baicalein and aucubin. Three replicates per group were included in each of the three runs of the experiments and analysis of variance (ANOVA) was used for statistical analysis. P. major and baicalein were not toxic to the cells at any of the concentrations examined. Aucubin was toxic to the cells only at the highest concentration tested (P = 0.0081). However, genistein was toxic to the cells at all of the concentrations examined except for the lowest concentration of 16.9 μg/ml (P = 0.985). P. major (-0.10 ± 0.11), aucubin (0.06 ± 0.16), baicalein (-0.10 ± 0.11), and genistein (-0.18 ± 0.07) all significantly (P ＜ 0.0001) inhibited ROS production from the neutrophils. P. major extract inhibited neutrophil ROS production, as did aucubin and baicalein. Therefore, these components should be investigated further with relation to the regulation of destructive ROS production in conditions such as periodontal disease.

参考文献 ( 24 ) 〈TOP〉

Borregaard, N,Sorensen, OE,Theilgaard‑Monch, K(2007).Neutrophil granules: A library of innate immunity proteins.Trends Immunol,28,340-345.
Chiang, LC,Chiang, W,Chang, MY,Lin, CC(2003).In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica.Am J Chin,31,225-234.
Gaydos, JM(1999).Indiana University School of Dentistry.
Hsieh, C,Hall, K,Ha, T,Li, C,Krishnaswamy, G,Chi, DS(2007).Baicalein inhibits IL‑1β‑ and TNF‑α‑induced inflammatory cytokine production from human mast cells via regulation of the NF‑κB pathway.Clin Mol Allergy,5,5.
Hung, JY,Yang, CJ,Tsai, YM,Huang, HW,Huang, MS(2008).Antiproliferative activity of aucubin is through cell cycle arrest and apoptosis in human non‑small cell lung cancer A549 cells.Clin Exp Pharmacol Physiol,35,995-1001.

被引用文献 ( 1 ) 〈TOP〉

Thessy Dewi Anisari,Sitarina Widyarini,Namira Lianika,Hilmy Ramadhan Wicaksono,Dimas Adhi Pradana,Didit Erwin Saputra,Asih Triastuti(2022).Anti-rheumatoid activity of a hexane-insoluble fraction from Plantago major in female Wistar rats induced by Complete Freund's Adjuvant.Journal of Traditional and Complementary Medicine,12(3),219-224.

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