Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants-A comprehensive review

Piyush Mehta; Rishi Shah; Sathiyanarayanan Lohidasan; K.R. Mahadik

doi:10.1016/j.jtcme.2014.11.041

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医药卫生 > 中医药学

DOI： 10.1016/j.jtcme

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Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants-A comprehensive review

Piyush Mehta ； Rishi Shah ； Sathiyanarayanan Lohidasan ； K.R. Mahadik

Journal of Traditional and Complementary Medicine ； 5 卷 4 期 (2015 / 10 / 01) ， P207 - 227

英文 DOI： 10.1016/j.jtcme.2014.11.041

Pharmacokinetics ； Phytoconstituents ； Traditional Chinese medicines (TCM) ； Traditional medicinal systems (TMS) ； ADME

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摘要 │ 参考文献 (60) │ 被引用文献 (1) │ 国际计量

摘要〈TOP〉

Herbal medicine, the backbone of traditional medicine, has played an important role in human health and welfare for a long period. Traditional therapeutic approaches of regional significance are found in Africa, South and Central America, China, India, Tibet, Indonesia, and the Pacific Islands. The considerable scientific significance and commercial potential of traditional medicines have resulted in increased international attention and global market demands for herbal medicines, especially Chinese herbal medicines. Herbal medicines currently are the primary form of health care for the poor in the developing countries, and also are widely used as a supplement or substitute for conventional drugs in developed countries. These traditional medicines have a pivotal role in the treatment of various ailments and more than 50% of drugs used in Western pharmacopoeia are isolated from herbs or derived from modifications of chemicals found in plants. Herbal medicines usually contain a complex mixture of various bioactive molecules, which make its standardization complicated, and there is little information about all compounds responsible for pharmacological activity. Several research papers have been published that claim pharmacological activity of herbal medicines but few are discussing the role of the exact phytoconstituent. Understanding the pharmacokinetic profile of such phytoconstituents is essential. Although there are research papers that deal with pharmacokinetic properties of phytoconstituents, there are a number of phytoconstituents yet to be explored for their kinetic properties. This article reviews the pharmacokinetic profile of 50 different therapeutically effective traditional medicinal plants from the year 2003 onward.

参考文献 ( 60 ) 〈TOP〉

Bai, X,Qu, J,Lu, J,Kano, Y,Yuan, D(2011).Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MS.J Chromatogr B,879,395-402.
Chen, C,Qi, L,Yi, L,Li, P,Wen, X(2009).Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation.J Chromatogr B.,877,159-165.
Chen, X,Lai, Y,Cai, Z(2012).Simultaneous analysis of strychnine and brucine and their major metabolites by liquid chromatography-electrospray ion trap mass spectrometry.J Anal Toxicol,36,171-176.
Chen, Z,Sun, J,Chen, H(2010).Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats.Fitoterapia,81,1045-1052.
Dai, J,Chen, X,Cheng, W(2008).A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine.J Chromatogr B.,868,13-19.

被引用文献 ( 1 ) 〈TOP〉

Zeya Ul Haque,Mohd Saif Khan,Mohammad Fazil,Gulam Rabbani,Arpita Rai,Ansul Kumar,Amit Kumar(2022).Role of herbal medicines in the management of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.Journal of Traditional and Complementary Medicine,12(1),100-113.

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