Enhancement of Vasorelaxation in Hypertension Following High-Intensity Exercise

Ai-Lun Yang; Chia-Wen Lo; Jen-Ting Lee; Chia-Ting Su

doi:10.4077/CJP.2011.AMM011

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医药卫生 > 基础医学

DOI： 10.4077/CJP

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Enhancement of Vasorelaxation in Hypertension Following High-Intensity Exercise

Ai-Lun Yang ； Chia-Wen Lo ； Jen-Ting Lee ； Chia-Ting Su

The Chinese Journal of Physiology ； 54 卷 2 期 (2011 / 04 / 01) ， P87 - 95

英文 DOI： 10.4077/CJP.2011.AMM011

exercise ； vasorelaxation ； aorta ； nitric oxide ； superoxide

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摘要 │ 参考文献 (41) │ 被引用文献 (3) │ 国际计量

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Exercise can ameliorate vascular dysfunction in hypertension, but its underlying mechanism has not been explored thoroughly. We aimed to investigate whether the high-intensity exercise could enhance vasorelaxation mediated by insulin and insulin-like growth factor-1 (IGF-1) in hypertension. Sixteen-week-old spontaneously hypertensive rats were randomly divided into non-exercise sedentary (SHR) and high-intensity exercise (SHR+Ex) groups conducted by treadmill running at a speed of 30 m/min until exhaustion. Age-matched Wistar-Kyoto rats (WKY) were used as the normotensive control group. Immediately after exercise, the agonist-induced vasorelaxation of aortas was evaluated in organ baths with or without endothelial denudation. Selective inhibitors were used to examine the roles of nitric oxide synthase (NOS) and phosphatidylinositol-3 kinase (PI3K) in the vasorelaxation. By adding superoxide dismutase (SOD), a superoxide scavenger, the role of superoxide production in the vasorelaxation was also clarified. We found that, [1] the high-intensity exercise significantly (P＜0.05) induced higher vasorelaxant responses to insulin and IGF-1 in the SHR+Ex group than that in the SHR group; [2] after endothelial denudation and pre-treatment of the PI3K inhibitor, NOS inhibitor, or SOD, vasorelaxant responses to insulin and IGF-1 became similar among three groups; [3] the protein expression of insulin receptor, IGF-1 receptor, and endothelial NOS (eNOS) was significantly (P＜0.05) increased in the SHR+Ex group compared with the SHR group; [4] the relaxation to sodium nitroprusside, a NO donor, was not different among three groups. Our findings suggested that the high-intensity exercise ameliorated the insulin-and IGF-1-mediated vasorelaxation through the endothelium-dependent pathway, which was associated with the reduced level of superoxide production.

参考文献 ( 41 ) 〈TOP〉

Yang, A. L.,Su, C. T.,Lin, K. L.,Lee, S. D.(2008).Enhancement of vascular function mediated by insulin and insulin-like growth factor-1 following single exercise session.Chin. J. Physiol.,51,71-77.
连结：
Amundsen, B. H.,Rognmo, O.,Hatlen-Rebhan, G.,Slordahl, S. A.(2008).High-intensity aerobic exercise improves diastolic function in coronary artery disease.Scand. Cardiovasc. J.,42,110-117.
Brook, R. D.,Julius, S.(2000).Autonomic imbalance, hypertension, and cardiovascular risk.Am. J. Hypertens.,13(6 Pt 2),112S-122S.
Ceriello, A.(2008).Possible role of oxidative stress in the pathogenesis of hypertension.Diabetes Care,31,S181-S184.
Chen, C.,Korshunov, V. A.,Massett, M. P.,Yan, C.,Berk, B. C.(2007).Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways.J. Vasc. Res.,44,504-512.

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