以X光為光源照射摻雜碳的二氧化鈦多孔奈米粒子產生自由基用於腫瘤治療

蔡敏雄

doi:10.6342/NTU201601799

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以X光为光源照射掺杂碳的二氧化钛多孔奈米粒子产生自由基用於肿瘤治疗

Porous C-doped TiO2 nanoparticles exposed to X-ray to induce free radicals for tumor treatment

蔡敏雄 , 硕士　　导师：林峯辉　　

繁体中文 DOI： 10.6342/NTU201601799

肿瘤治疗；光动力疗法；碳掺杂二氧化钛； X光；自由基；活性氧物质； Tumor treatment ； Photodynamic therapy ； TiO2:C ； X-ray ； free radicals ； ROS

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摘要 │ 参考文献 (46) │ 国际计量

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Among many cancer therapies, photodynamic therapy is the one which causes less side effects due to the small area illuminated by the light with specific wavelength to excite the photosensitizer. However, the therapy is limited by its penetration depth because of the selection of photosensitizer and light source. Only tumors on the surface of the body could be treated, for example, skin cancer, and head and neck cancer. The study tried to solve this problem by providing a method that tumor cells could be killed by free radicals which were produced by the synthesized material (TiO2:C) excited by X-ray. X-ray could penetrate deeper than other light source but was not so much harmful as gamma ray.
    TiO2:C with rough surface and porous structures was synthesized successfully by   the sol-gel method. The size of the particles was between 200 - 300 nm. The observed formation of the bonding of O-Ti-C could narrow its band-gap to 3.07 eV which is lower than undoped TiO2. In addition, under X-ray exposure, TiO2:C produced free radicals so that Methylene blue was degraded.
    TiO2:C was proved biocompatible through WST-1 and LDH assay for 3T3 cell. In terms of in vitro study, after immersed in the medium with TiO2:C powder and excited by X-ray, the cytotoxicity of tumor cell, A549, was larger than control group for continuous 2 days. As for in vivo study, the safety of synthesized TiO2:C was proved when examining the physical condition, the blood biochemical analysis, and histological analysis of BALB/c nude mice. Tumors appeared successfully after subcutaneous injection of A549 tumor cells to nude mice.  When treated with TiO2:C injection followed by X-ray exposure, growing of tumors was inhibited.
    In summary, the method was of great effect for degradation of organic dye, in vitro study, and in vivo study. In the future, better experimental parameters might be needed, and clinical trials for human might be conducted. Then, a new way for photodynamic therapy and a better life for those suffered cancer could be expected

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[2] 卫生福利部中央健康保险署. 103年全民健康保险统计. 资讯公开 2015.
连结：
[3] 卫生福利部中央健康保险署. 103年各类癌症健保前10大医疗支出统计. 104年卫生福利部新闻 2015.
连结：
[6] Gerber DE, Chan TA. Recent advances in radiation therapy. American Family Physician. 2008; 78:1254-62.
连结：
[7] Ahmad SS, Duke S, Jena R, Williams MV, Burnet NG. Advances in radiotherapy. BMJ. 2012; 345.
连结：
[8] Society AC. How chemotherapy drugs work. Chemotherapy 2016.
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引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。