中草藥方劑對癌症惡病質之影響

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中草药方剂对癌症恶病质之影响

The effect of Chinese herbal medicines on cancer cachexia

杨婷婷 , 硕士　　导师：徐士兰;吴俊錡　　

繁体中文

癌症；恶病质；四君子汤； Lewis lung cancer cell ； Cancer ； cachexia ； Chinese herbal medicine ； Sijunzi Tang

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摘要 │ 参考文献 (107) │ 国际计量

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Cancer cachexia occurs in up to 80% of patients with advanced cancers and accounts for nearly 40% of cancer-related death. Typical symptoms of cancer cachexia are massive loss of body weight, anorexia, inflammation and pronounced muscle-wasting resulting in a drastic decrease of quality of life. It is also associated with poor responses to chemotherapy and survival. However, few therapeutic options are currently available for cancer cachexia. The management of cachexia remains a big challenge now. Chinese herbal medicine have been used to prevent or cure diseases for thousands of years. More and more research show that Chinese herbal medicine with less side effects, enhancing immune system, inhibiting protein catabolism, boosting the appetite and body weight, which maybe a promising treatment strategy and development tendency for cancer cachexia syndrome. Sijunzi Tang is an assembled formula for qi vacuity. It is a multiple component herbal extract. Sijunzi Tang has function not only in strengthening the spleen and replenishing qi but also in treating various kinds of symptoms from the qi vacuity. However, the effect of Sijunzi Tang on cancer cachexia is limitedly explored. In this study, Lewis lung carcinoma (LLC) tumor cells were subcutaneously inoculated into the flank region of 8-week-old female C57BL/6 mice to establish a mouse cancer cachexia model. LLC tumor cell implanted mice were oral fed with Sijunzi Tang and another Chinese herbal medicine five days a week for 4 weeks. Our results showed that supplementation of Chinese herbal medicine resulted in a significant improvement of food intake, myofiber cross-sectional area and physical performance in cancer cachexia mice. Moreover, these two Chinese herbal medicine not only prevented muscle wasting but also completely reversed prior loss of skeletal muscle and cardiac atrophy induced by LLC. Furthermore, feeding with Chinese herbal medicine could prolong the survival of cancer cachexic mice, but not inhibit the tumor growth. Overall, our studies demonstrated that the tested two Chinese herbal formula could ameliorate the LLC-induced cancer cachexia. Besides, the therapeutic effect of Chinese herbal medicine was more effective than Sijunzi Tang. These findings indicate that Chinese herbal medicine might be a promising drug to treat cancer cachexic patients.

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1. Chen, X., Wu, Y., Yang, T., Wei, M., Wang, Y., Deng, X., Shen, C., Li, W., Zhang, H., Xu, W., Gou, L., Zeng, Y., Zhang, Y., Wang, Z., and Yang, J. (2016) Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. J Cachexia Sarcopenia Muscle 7, 225-232
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2. Donohoe, C. L., Ryan, A. M., and Reynolds, J. V. (2011) Cancer cachexia: mechanisms and clinical implications. Gastroenterol Res Pract 2011, 601434
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3. Somerville, C., and Koornneef, M. (2002) A fortunate choice: the history of Arabidopsis as a model plant. Nat Rev Genet 3, 883-889
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4. Rennie, M. J. (2009) Anabolic resistance in critically ill patients. Crit Care Med 37, S398-399
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5. Johns, N., Stephens, N. A., and Fearon, K. C. (2013) Muscle wasting in cancer. Int J Biochem Cell Biol 45, 2215-2229
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。