隨機、雙盲、以安慰劑為對照之人體研究評估補充刺五加萃取物對紅血球生成素反應不良之腎臟透析病人抗發炎及效益評估:先期試驗

張育瑛

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随机、双盲、以安慰剂为对照之人体研究评估补充刺五加萃取物对红血球生成素反应不良之肾脏透析病人抗发炎及效益评估:先期试验

A randomized, double-blind, placebo-controlled trial to evaluate the anti-inflammatory efficacy and health benefits of Eleutherococcus senticosus for subjects under renal dialysis with erythropoietin hyporesponsiveness: A pilot study

张育瑛 , 硕士　　导师：杨乃成　　

繁体中文

刺五加；肾脏透析；红血球生成素反应不良；贫血；发炎； Eleutherococcus senticosus ； renal dialysis ； erythropoietin hyporesponsiveness ； anemia ； inflammation

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摘要 │ 参考文献 (41) │ 国际计量

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The main cause for the subjects under renal dialysis with erythropoietin hyporesponsiveness is inflammation which is highly correlated with mortality rates of renal dialysis patients. The Eleutherococcus senticosus (ES) has anti-inflammatory activity confirmed by in vitro and in vivo experiments; however, it’s health benefits is not clear for the subjects under renal dialysis with erythropoietin hyporesponsiveness. This pilot study focused on inflammatory indicators, anemia indicators, health indicators and safety assessments on the subjects with oral administration of ES. The study is expected to recruit 30 renal dialysis patients with erythropoietin hyporesponsivenes and the subjects were randomly assigned into three groups, including mono-ES formula, combined-ES formula and placebo groups. Before and after three months of oral administration, subject’s blood specimens were taken and all indices were tested. The study has currently recruited 16 cases, but only 9 subjects completed three months of ES supplement, and their data were analyzed. Due to the small sample size, in addition to the three groups, the mono- ES and combined- ES groups were combined as experimental ES group for analysis. The Wilcoxon signed rank test compared data obtained pre- and post-treatment. The Kruskal-Wallis test was used to compare the continuous variables among the three groups, and the the Mann-Whitney U test was performed to compare the difference between the two groups. After taking ES for three months, we found that reticulocyte have significantly elevated. The safety indicators all showed no difference when comparing with placebo. The results of this study show that the supplements increase reticulocyte count for the subjects, indicating ES might have the ability to enhance patient’s erythropoiesis. Due to the current number of cases is too small, all the results should be further confirmed.

参考文献 ( 41 ) 〈TOP〉

Chan DT,Watts GF,Irish AB,Dogra GK.(2015).Insulin resistance and vascular dysfunction in chronic kidney disease: mechanisms and therapeutic interventions. Nephrol Dial Transplant.pii.gfv,326.
连结：
Chen C,Wu H, Zhong L, Wang X, Xing ZJ, Gao BH.(2015).Impacts of parathyroidectomy on renal anemia and nutritional status of hemodialysis patients with secondary hyperparathyroidism.Int J Clin Exp Med.;8(6),9830-8.
连结：
Cheng X, Yu G, Hu J, Xu X, Luo F, Shen P, Zhang G, Yang N.(2016) .Clinical study of Shengxuening tablet combined with rHuEPO for the treatment of renal anemia of maintenance hemodialysis patients. Exp Ther Med. ;12(1),157-160.
连结：
Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure. J Am Soc Nephrol. ;15(7),1877-82.
连结：
Delanaye P, Glassock RJ, Pottel H, Rule AD.(2016).An Age-Calibrated Definition of Chronic Kidney Disease: Rationale and Benefits. Clin Biochem Rev. 37(1),17-26.
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。