蘋果多酚抑制乳癌轉移之作用

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苹果多酚抑制乳癌转移之作用

Apple polyphenols inhibit breast cancer metastasis

陈盈均 , 硕士　　导师：李彗祯　　

繁体中文

乳癌；肿瘤转移；苹果多酚； Breast cancer ； Metastasis ； Apple polyphenol ； Focal adhesion kinase

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摘要 │ 参考文献 (161) │ 国际计量

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Apple polyphenol (AP) has been reported to possess to potent anti-tumor activity on different kinds of cancers, but the effects of AP on metastatic capability of breast cancer is not clarified. Herein, we aimed to investigate inhibitory effects of AP on breast cancer cells. Our results showed that AP treatments won’t significantly affect cell viability of breast cancer cells MCF-7, MDA-MB-231 and MDA-MB-453 but suppress migration and invasion of the cells when the AP concentration under 0.2mg/ml. Interestingly, we found that AP treatments reduced expression of focal adhesion kinase (FAK). Besides, the activation of FAK downstream effectors such as Paxillin, PI3K, Akt and mTOR were also inhibited by AP treatments. To facilitate further research on the feasibility of a clinically effect on breast cancer metastasis of AP, we examine the effect of co-treatment with Paclitaxel and AP. Paclitaxel is an important agent in the treatment of breast cancer. It is necessary to know whether co-treatment with a commonly applied drug and AP has a synergistic effect. Here, we present a detailed study about the effects of AP co-treated with Paclitaxel. We further demonstrated that inhibition of FAK expression by co-treating with AP and paclitaxel was more significant than AP-only treatment or paclitaxel-only treatment. We also showed that co-treatment with AP and paclitaxel suppressed FAK signaling pathway and FAK downstream effectors. To validate the suppressive effects of AP, we used a isograft model to clarify. We injected 4T1 cells into ICR mice through tail vein and observed the suppressive metastasis effects and tumorigenesis of AP treatments. Collectively, these findings indicate that AP treatments significantly inhibited invasion of MCF-7, MDA-MB-231 and MDA-MB-453 cells through reducing expression of FAK. There is the same result that AP suppressed metastasis and tumorigenesis in vivo. However, co-treatment with AP and paclitaxel shows more effective than single use on inhibiting FAK pathway.

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2. D. T. Ramsay, J. C. Kent, R. A. Hartmann and P. E. Hartmann. Blackwell Publishing, Ltd. Anatomy of the lactating human breast redefined with ultrasound imaging. J. Anat. pp525–534 (2005)
连结：
3. Pandya S, Moore RG. Breast development and anatomy. Clin Obstet Gynecol. 54(1):91-5. doi: 10.1097 (2011)
连结：
4. Russell CG, Taki S, Azadi L, Campbell KJ, Laws R, Elliott R, Denney-Wilson E. A qualitative study of the infant feeding beliefs and behaviours of mothers with low educational attainment. BMC Pediatr. 16(1):69. (2016)
连结：
5. Komisaruk, B. R., Wise, N., Frangos, E., Liu, W.-C., Allen, K. and Brody, S. Women's Clitoris, Vagina, and Cervix Mapped on the Sensory Cortex: fMRI Evidence. The Journal of Sexual Medicine: 2822–2830. doi:10.1111 (2011).
连结：
7. Wood K, Cameron M, Fitzgerald K. Breast Size, Bra Fit and Thoracic Pain in Young Women: A Correlational Study. Chiropractic & Osteopathy 16: 1.doi:10.1186 / 1746-1340-16-1. PMC 2275741 (2008).
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。