黃花蜜菜藥酒萃取物對人類多型性神經膠母細胞瘤細胞株之影響與相關訊息機制研究

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黄花蜜菜药酒萃取物对人类多型性神经胶母细胞瘤细胞株之影响与相关讯息机制研究

The effect and mechanism of Wedelia chinensis extract on human glioblastoma multiforme cells

叶沛蓉 , 硕士　　导师：曾博修　　

繁体中文

黄花蜜菜；神经胶母细胞瘤；脑癌； Wedelia chinensis ； glioblastoma ； brain cancer

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Glioblastoma multiforme (GBM), known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive brain cancer with the worst prognosis and survival time. Standard treatment for GBM includes surgical resection, combination with radiotherapy and chemotherapy. However, the anatomic location of gliomas makes it very difficult to surgically remove the tumor and it is impossible to avoid any damage to vital brain regions with radiotherapy. Therefore, therapeutic strategies for malignant glioma are urgently required improved. Wedelia chinensis is known as a traditional Chinese herbal medicine has been shown to have anti-inflammatory properties, anti-hepatic toxicity, and neuropharmacological activity. Recent evidences have suggested that Wedelia chinensis extract inhibits the growth of prostate cancer and breast cancer cells. However, little is known about the effects of Wedelia chinensis extract on glioblastoma. We herein intend to investigate the effect of Wedelia chinensis extract on human glioblastoma cells.
　　In this study, significantly decreased survival ratios of GBM8401 and U-87MG cells were detected in the presence of Wedelia chinensis extract. Significantly decreased migration was detected in GBM8401 cells treated with Wedelia chinensis extract. Additionally, significantly increased sub-G1 population was observed in GBM8401 cells that were treated with Wedelia chinensis extract as well the significantly increased P21 and decreased cyclin D1 proteins,  significantly decreased Bcl-2 (anti-apoptotic) proteins and increased Bax (pro-apoptotic), Cytochrome C, Apaf-1, Caspase-9, Caspase-3 were detected by Western blot analysis. Altogether, these results demonstrated that treatment of GBM8401 cells with Wedelia chinensis extract induced cell cycle arrest and apoptosis, suggesting Wedelia chinensis as a useful alternative choice in treatment of GBM.

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1. 104年行政院卫生署癌症统计
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3. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA and Cavenee WK (2007) Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21:2683-710. doi: 10.1101/gad.1596707
连结：
4. van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T and de Vries HE (2015) Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. Drug Resist Updat 19:1-12. doi: 10.1016/j.drup.2015.02.002
连结：
5. Faraz S, Pannullo S, Rosenblum M, Smith A and Wernicke AG (2016) Long-term survival in a patient with glioblastoma on antipsychotic therapy for schizophrenia: a case report and literature review. Ther Adv Med Oncol 8:421-428. doi: 10.1177/1758834016659791
连结：
6. Manrow RE, Beckwith M and Johnson LE (2014) NCI's Physician Data Query (PDQ(R)) cancer information summaries: history, editorial processes, influence, and reach. J Cancer Educ 29:198-205. doi: 10.1007/s13187-013-0536-3
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。