白血球粒線體去氧核醣核酸拷貝數、多形性，氧化傷害與情感性疾患的關聯性探討

張正辰

山西大学，您好！

感谢采购，人社期刊库｜人社论文库，期间：2025/01/01~2025/12/31

感谢试用，科学期刊库｜科学论文库，期间：2024/10/20~2025/01/20

浏览高级检索

关闭
检索检索高级检索出版物检索
浏览期刊主题浏览核心期刊浏览期刊拼音浏览

关闭

查询符号(半角)	查询符号意义说明
空格	表示为「AND」两个查询词之交集
双引号 ( " " )	片语以双引号标示开始及结束，而且只寻找出现顺序相同的字词，例： " image process "
?	表示一个字母切截，输入两个?表两个字母，依此类推，例：输入「Appl?」，查得结果应为appl e , appl y … ( 常用于英文字查询 )
*	表示不限字母切截，由0~n. 例：输入「appl*」，查得结果应为appl e , appl es , appl y , appl ied , appl ication … ( 常用于英文字查询 )
AND、OR、NOT	布尔逻辑组合关键字，用来扩大或缩小查询范围的技巧。 (1) AND ：缩小查询范围 (2) OR ：扩大查询范围(3) NOT：排除不相关的范围

DOI 是数位物件识别码（ D igital O bject I dentifier ）的简称，
为物件在网路上的唯一识别码，可用于永久连结并引用目标物件。

使用DOI作为永久连结

每个DOI号前面加上「 http://dx.doi.org/ 」便成为永久网址。
如以DOI号为 10.5297/ser.1201.002 的文献为例，此文献的永久连结便是： http://dx.doi.org/ 10.5297/ser.1201.002 。
日后不论出版单位如何更动此文献位置，永久连结所指向的位置皆会即时更新，不再错失重要的研究。

引用含有DOI的文献

有DOI的文献在引用时皆应同时引用DOI。若使用APA、Chicago以外未规范DOI的引用格式，可引用DOI永久连结。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。

书目管理工具

相关连结

问题回报

全文下载

白血球粒线体去氧核醣核酸拷贝数、多形性，氧化伤害与情感性疾患的关联性探讨

The Association of Leukocyte Mitochondrial DNA Copy Number, Polymorphisms, and Oxidative Damage in Affective Disorders

张正辰 , 博士　　导师：赖德仁　　

英文

粒线体；氧化伤害；双极性疾患；重郁症； mitochondria ； oxidative damage ； bipolar disorder ； major depressive disorder

0 个人觉得这篇文章赞

摘要 │ 参考文献 (97) │ 国际计量

摘要〈TOP〉

并列摘要〈TOP〉

Aims: This dissertation consists of two parts: (1) To compare alterations of mitochondria DNA (mtDNA) copy number, single nucleotide polymorphisms (SNPs), and oxidative damage of mtDNA in clinically stable patients with bipolar I disorder (BD) and normal controls. (2) The same research topics were investigated between patients of major depressive disorder (MDD) and normal controls.

Methods: Patients met DSM-IV diagnostic criteria for BD and MDD were recruited from the psychiatric outpatient clinic at a medical center in Central Taiwan. They were clinically stable and their medications had not changed for at least the preceding two months. Exclusion criteria were substance-induced psychotic disorder, eating disorder, anxiety disorder or illicit substance abuse. All participants had no history of chronic medical illness, no indication of acute infection and were not pregnant. Comparison subjects did not have any history of major psychiatric disorders and they were non-smokers. By analyzing peripheral blood leukocytes, copy number, SNPs and oxidative damage of mtDNA were compared between patients and controls.
Results: Forty BD patients, 40 MDD patients and 70 comparison subjects were included in this study. The median age of the subjects was 42, 41.5 and 38 years in MDD, BD and comparison groups, respectively. Leukocyte mtDNA copy number was significantly lower in BD and MDD patients than that of the comparison group (p<0.001 and p=0.037). All patients had significantly higher mitochondrial oxidative damage than the comparison group. The SNP of mtDNA C5178A and A10398G were similar in patients and control groups. After generalized linear model adjusting with related variables, mtDNA copy number was still significantly lower both in BD (p<0.001) and MDD group (p<0.001). MtDNA oxidative damage was positively correlated with age. Antipsychotic use was negatively associated with mtDNA copy number (p=0.036) in MDD group.

Conclusions and Suggestions: Possible involvement of oxidative damage and mitochondria in the pathophysiology of BD and MDD needs more large-scale studies. Future study of mitochondrial dysfunction in affective disorders may bring some light in the development of disease biomarker. The study is cross-sectional with no longitudinal follow up. This relationship between mitochondrial dysfunction and affective disorders was correlational instead of causal. The study cohort is clinically stable and generalizability of our result to other cohort should be cautiously considered.

参考文献 ( 97 ) 〈TOP〉

Andreazza, A. C. (2012). Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders. [Review]. Mol Biosyst, 8(10), 2503-2512. doi: 10.1039/c2mb25118c
连结：
Ballard, J. W., Melvin, R. G., Miller, J. T., & Katewa, S. D. (2007). Sex differences in survival and mitochondrial bioenergetics during aging in Drosophila. [Research Support, N.I.H., Extramural
连结：
Research Support, U.S. Gov't, Non-P.H.S.]. Aging Cell, 6(5), 699-708. doi: 10.1111/j.1474-9726.2007.00331.x
连结：
Belmaker, R. H., & Agam, G. (2008). Major depressive disorder. [Review]. N Engl J Med, 358(1), 55-68. doi: 10.1056/ NEJMra073096
连结：
Ben-Shachar, D., Zuk, R., Gazawi, H., Reshef, A., Sheinkman, A., & Klein, E. (1999). Increased mitochondrial complex I activity in platelets of schizophrenic patients. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum, 2(4), 245-253. doi: 10.1017/S1461145799001649
连结：

国际计量

〈TOP〉

E-mail ：

文章公开取用时，将寄通知信至您填写的信箱地址

E-mail ：

使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。