荷葉黃酮萃取物抑制肥胖因子促進人類乳癌細胞的轉移之作用

游孟勳

doi:10.6834/CSMU.2013.00208

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荷叶黄酮萃取物抑制肥胖因子促进人类乳癌细胞的转移之作用

The flavonoid-rich extract from Nelumbo Nucifera leave inhibits obesity factor induced breast cancer metastasis

游孟勳 , 硕士　　导师：王朝钟　　

繁体中文 DOI： 10.6834/CSMU.2013.00208

荷叶黄酮萃取物；脂肪细胞因子；乳癌细胞株(MCF-7) ； Nelumbo Nucifera leave extract (NLE) ； adipocyte conditioned medium(CM) ； Breast cancer cell line(MCF-7)

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Breast cancer is the most common cancer in women in the Taiwan. Then breast cancer deaths accounted for 28.4% of all the cancer deaths, and have been associated with obesity. Previous studies, has been confirmed Nelumbo nucifera leave extract (NLE) can effectively reduce the fatty liver, atherosclerosis, hyperlipidemia and anti-oxidative properties. Thus, we investigated the relationship between obesity and breast cancer, and evaluated the inhibitory effect of NLE on the adipocytes-induced breast cancer progression. Adipocyte secreted conditioned medium (CM) noticeably induced breast cancer migration. NLE diminished the CM-induced migration number of breast cancer cell by boyden chamber assay. A direct correlation was found between adipocyte and breast cancer cell migration. Similarly, we used of ECIS assay, wound healing assay and transwell assay identical results were found. To investigate the molecular mechanisms of breast cancer cell migration using two-dimensional gel electrophoresis. We found CM increased the proteins level of the Hsp90, StarD10, Peroxiredoxin 6. The results suggest that CM stimulates migration of breast cancer cells, perhaps through the interaction of these proteins. Under the CM treatment, phosphorylated JNK, PI3K/Akt, StarD10 and Peroxiredoxin 6 levels of MCF-7 cells treated with NLE can significantly inhibited the protein expression were measured by Western blot analysis. These data indicate adipocytes provide a major component of the microenvironment for rapid tumor growth and migration, and this increase was inhibited significantly by NLE treatment. In summary, the study indicated that the future for the treatment of metastatic breast cancer, NLE inhibited cancer metastasis has developed into a process of natural drugs.

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引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。