研究雙離子型β-羥基丁酸酯纖維薄膜的組織相容性控制

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doi:10.6840/cycu201600320

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研究双离子型β-羟基丁酸酯纤维薄膜的组织相容性控制

A Study of Zwitterionic Polyhydroxybutyrate Fibrous Membranes with Controlled Cytocompatibility

许丰发 , 硕士　　导师：张雍;费安东　　

英文 DOI： 10.6840/cycu201600320

β-羟基丁酸酯；双离子； PHB ； zP(4VP-r-ODA) ； electrospinning ； antifouling membranes ； tissue engineering scaffold

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In this work, electrospinning process was used to form poly(3-hydroxybutyric acid) (PHB) fibrous membranes. Fibers were then coated with zwitterionic poly(4-vinylpyridine-random-octadecylacrylate) zP(4VP-r-ODA), in order to enhance the resistance of membranes to biofouling. Coating density was in the range 0-2.5 mg/cm2. The structure was characterized by SEM, which showed a significant decreasing of surface porosity with coating density, also supported by the assessment of surface porosity. The presence of zwitterionic polymer onto the fibers was further evidenced by FT-IR and XPS measurements. The later revealed the presence of a peak at a binding energy of 402 eV, ascribed to the quaternary amine of zP(4VP-r-ODA). The copolymer also enabled to importantly decrease the water contact angle (from 130° to 80°) and increase the hydration capacity of electrospun fibers. The formation of a hydration protective layer resulted in very low level of protein adsorption, as it was measured to be around 0.01 mg/cm2 for membrane with the highest coating density, while it was 0.17 mg/cm2 for virgin PHB membrane. Similar results were obtained with lysozyme and fibrinogen proteins. At a microscale, the adhesion of bacteria (Escherichia coli) and that of blood cells – erythrocytes, leukocytes, platelets and whole blood – was drastically reduced for coating density as low as 0.5 mg/cm2. A similar trend was observed with fibroblasts. Taken all together, these results suggests that the zP(4VP-r-ODA) coated PHB fibers could be used as tissue engineering scaffold to control the cell growth and tissue regeneration.

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[1] Meyer, U.; Meyer, Th.; Handschel, J.; Wiesmann, H. P. Fundamentals of Tissue Engineering and Regenerative Medicine, 2009
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[2] Vacanti, J.; Vacanti, C. A. The History and Scope of Tissue Engineering, 3rd edition, 2007
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[3] Buddy, D. R.; Allan, S. H.; Frederick, J. S.; Jack, E. L. An introduction to materials in medicine, Academic press, 2013
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[5] Lysaght, M. J.; Reyes, J. Review : The Growth of Tissue Engineering 7 (2001), 5
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[7] Lanza, R. P.; Langer, R.; Vacanti, J. Principles of Tissue Engineering, 2nd edition, 2000
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