可再生金奈米團簇捕捉自由基之研究

陳韻宇

doi:10.6840/cycu201800106

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可再生金奈米团簇捕捉自由基之研究

Investigation of Regenerable Gold Nanocluster as Free Radical Scavenger

陈韵宇 , 硕士　　导师：林政鞍　　

英文 DOI： 10.6840/cycu201800106

硫辛酸；金奈米团簇；双氧水；抑制DPPH检测；氧化还原反应；再生性材料； lipoic acid ； gold nanocluster ； H2O2 ； DPPH assay ； Redox reactions ； regenerable

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摘要 │ 参考文献 (90) │ 国际计量

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Free radicals are the factors that induce the cell's aging and produce related diseases, which can have a serious impact on the organism. Antioxidants have the ability to prevent and inhibit the free radicals. Gold nanocluster is also known as an artificial antioxidant, not only does it have a unique optical property but it can also react with a variety of free radicals, as a biological probe. In this study we have reported a 'one-pot synthesis' procedure to prepare fluorescent gold nanoclusters conjugated by lipoic acid, and further determined the surface structure, physical and chemical properties and the ability to scavenge free radicals. The trend of inhibiting free radicals was compared with vitamin C and gold nanoclusters, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydrogen peroxide reacted with gold nanoclusters, respectively, then renewal of the gold nanoclusters by common antioxidants from the body. In addition, X-ray photoelectron spectroscopy and Ellman's Reagent were used to measure the change in the surface of the gold nanoclusters during the redox process. The study found that the size of gold nanoclusters is about 2.32nm, with ultrabright luminescence, long-term and stable inhibition of DPPH. Comparing DPPH radical with hydrogen peroxide, we have found that both of them can oxidize gold nanoclusters, that is, they lose their ability to scavenge free radicals. They showed different spectral effects, indirectly found that the gold nanoclusters have a redox state. Finally, addition of glutathione to reduce the oxidation state of the gold nanoclusters and have the property to scavenge free radical again, but the fluorescence intensity decreased. However, the change of valence state of gold is closely related to the fluorescence intensity during the redox process. Ellman's Reagent also confirmed that GSH is involved in the reduction reaction and the in vivo circulation is implemented in this material. Moreover, the gold nanocluster can be regenerated by the biological cycle, ensuring gold nanoclusters have more applications and value.

参考文献 ( 90 ) 〈TOP〉

1. SadafKalam , M. Z., Rupal Singh and Sravani Ankati, Free Radicals: Implications in Etiology of Chronic Diseases and Their Amelioration through Nutraceuticals. Pharmacologia 2015, 6 (1), 11-20.
连结：
3. A.R. Smith, S. V. S., M. Widlansky, J.H. Suh and T.M. Hagen, Lipoic Acid as a Potential Therapy for Chronic Diseases Associated with Oxidative Stress. Current Medicinal Chemistry, 2004, 11, 1135-1146.
连结：
4. Erica Sharpe, D. A., and Silvana Andreescu, Artificial Nanoparticle Antioxidants. ACS Symposium Series 2011, 1083, 235–253.
连结：
5. Aldeek, F.; Muhammed, M. A. H.; Palui, G.; Zhan, N. Q.; Mattoussi, H., Growth of Highly Fluorescent Polyethylene Glycol- and Zwitterion-Functionalized Gold Nanoclusters. Acs Nano 2013, 7 (3), 2509-2521.
连结：
7. Weibo Cai, T. G., Hao Hong, and Jiangtao Sun, Applications of gold nanoparticles in cancer nanotechnology. Nanotechnol Sci Appl. 2008, 1, 17-32.
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使用DOI作为永久连结

引用含有DOI的文献

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。 如想对DOI的使用与概念有进一步了解，请参考 （ ） 。

DOI可强化引用精确性、增强学术圈连结，并给予使用者跨平台的良好使用经验，目前在全世界已有超过五千万个对象申请DOI。如想对DOI的使用与概念有进一步了解，请参考（）。