Mathematical modeling and optimal control of a deterministic SHATR model of HIV/AIDS with possibility of rehabilitation: a dynamic analysis

10.5556/j.tkjm.55.2024.5109

Pankaj Singh Rana；Nitin Sharma；Anupam Priyadarshi

Antiretroviral therapy (ART) ； basic reproduction number ； lyapunov ； optimal control ； Pontryagin's maximum principle

Tamkang Journal of Mathematics

55卷3期（2024 / 09 / 01）

267 - 285

英文

In the present work, we developed a deterministic SHATR (Susceptible - HIV infected -AIDS infected - Antiretroviral Treatment - Recovered) compartment model for HIV/AIDS. This model considers the disease outbreak due to a lack of awareness and treatment. The steady states of the proposed model system are obtained and analyzed by using the nonlinear stability theory of differential equations. The basic reproduction number is derived and explored to determine the stability and sensitivity index of some important relative parameters. Further, to know the global behavior of the model one parameter bifurcation study is discussed. Moreover, the optimal control theory has been applied to identify the optimal strategy by taking treatment and awareness for safe intercourse as control parameters. The control problem is solved analytically by using Pontryagin's maximum principle. Finally, the model is simulated to describe the optimality under various assumptions and the stability of equilibrium points.