题名

The Role of Matrix Metalloproteinases 8 Genotypes in Gastric Cancer Risk in Taiwan

作者

Te-Chun Hsia；Cin-Wun Wu；Hsin-Ting Li；Chi-Hsuan Cheng；Chia-Yi Pan；Tzu-Ching Shih；Te-Chun Shen；Wen-Shin Chang；Chia-Wen Tsai

关键词

drinking ； gastric cancer ； genotype ； MMP8 ； polymorphism ； smoking ； Taiwan

期刊名称

中西整合醫學雜誌

卷期/出版年月

21卷2期（2019 / 12 / 31）

页次

1 - 12

内容语文

英文
中文摘要

In post-genomic era, it is hypothesized that abnormal expression of matrix metalloproteinase 8 (MMP8), an collagenase in charge of regulating the extracellular matrix, may play a critical role in the development of gastric cancer, which is one of the global leading causes of death. Since the importance's of MMP8 genotype/phenotype has never been studied in literature about gastric cancer in Taiwan and all over the world, our aim is to investigate MMP8 promoter (C-799T) and exonic (Lys460Thr and Val436Ala) genotypes and gastric cancer susceptibility in a central Taiwan population based on China Medical University and Hospital. In the current study, the association of MMP8 C-799T, Lys460Thr and Val436Ala genotypes with gastric cancer risk was examined and evaluated among 121 gastric cancer cases and 363 gender- and age-matched non-cancer subjects via the typical genotyping methodology, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). In the results, we have noticed a slight but not-significant difference in the distribution of T allelic frequencies of the MMP8 C-799T genotype (odds ratio [OR]=0.86, 95% confidence interval [CI]=0.62-1.19, P=0.3669), but not in those exonic polymorphic sites, between the gastric cancer case and control groups. Those who had CT or TT variant genotypes at MMP8 C-799T showed a 0.89-and 0.73-fold (95%CI=0.57-1.38 and 0.35-1.56, P=0.6027 and 0.4189, P for trend =0.6813) risk of gastric cancer compared to those with CC. The risk CT and TT genotypes at MMP8 C-799T, Lys460Thr or Val436Ala have no synergistic effect with alcohol drinking, cigarrete smoking nor Helicobacter pylori infection status on gastric cancer risk determination. Overall, the pilot study suggested that the three polymorphic sites of MMP8 may contribute to gastric carcinogenesis non-significantly and may not be a practical biomarker for gastric cancer early detection and prevention, at least in Taiwan population.
主题分类 醫藥衛生 > 醫藥總論
醫藥衛生 > 中醫藥學
参考文献
  1. Bau, DT,Wang, HC,Liu, CS,Chang, CL,Chiang, SY,Wang, RF,Tsai, CW,Lo, YL,Hsiung, CA,Lin, CC,Huang, CY(2009).Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan.Chin J Physiol,52,411-418.
    連結：
  2. Balbin, M,Fueyo, A,Tester, AM,Pendas, AM,Pitiot, AS,Astudillo, A,Overall, CM,Shapiro, SD,LopezOtin, C(2003).Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.Nat Genet,35,252-257.
  3. Bayramoglu, A,Gunes, HV,Metintas, M,Degirmenci, I,Mutlu, F,Alatas, F(2009).The association of MMP-9 enzyme activity, MMP-9 C1562T polymorphism, and MMP-2 and -9 and TIMP-1, -2, -3, and -4 gene expression in lung cancer.Genet Test Mol Biomarkers,13,671-678.
  4. Birkedal-Hansen, H,Moore, WG,Bodden, MK,Windsor, LJ,Birkedal-Hansen, B,DeCarlo, A,Engler, JA(1993).Matrix metalloproteinases: a review.Crit Rev Oral Biol Med,4,197-250.
  5. Chiu, CF,Wang, CH,Wang, CL,Lin, CC,Hsu, NY,Weng, JR,Bau, DT(2008).A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan.Ann Surg Oncol,15,514-518.
  6. Chou, AK,Hsiao, CL,Shih, TC,Wang, HC,Tsai, CW,Chang, WS,Liu, LC,Way, TD,Chung, JG,Bau, DT(2017).The contribution of matrix metalloproteinase-7 promoter genotypes in breast cancer in Taiwan.Anticancer Res,37,4973-4977.
  7. Chuang, CL,Wang, CH,Hsu, CH,Hsiao, CL,Chen, GL,Yen, ST,Li, HT,Chang, WS,Tsai, CW,Wang, SC,Bau, DT(2017).Contribution of double-strand break repair gene Nijmegen breakage syndrome 1 genotypes, gender difference and smoking status to Taiwanese lung cancer.Anticancer Res,37,2417-2423.
  8. Decock, J,Long, JR,Laxton, RC,Shu, XO,Hodgkinson, C,Hendrickx, W,Pearce, EG,Gao, YT,Pereira, AC,Paridaens, R,Zheng, W,Ye, S(2007).Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis.Cancer Res,67,10214-10221.
  9. Ferlay, J,Shin, HR,Bray, F,Forman, D,Mathers, C,Parkin, DM(2010).Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.Int J Cancer,127,2893-2917.
  10. Fuchs, CS,Mayer, RJ(1995).Gastric carcinoma.N Engl J Med,333,32-41.
  11. Gonzalez-Arriaga, P,Lopez-Cima, MF,Fernandez-Somoano, A,Pascual, T,Marron, MG,Puente, XS,Tardon, A(2008).Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.BMC Cancer,8,378.
  12. Gutierrez-Fernandez, A,Fueyo, A,Folgueras, AR,Garabaya, C,Pennington, CJ,Pilgrim, S,Edwards, DR,Holliday, DL,Jones, JL,Span, PN,Sweep, FC,Puente, XS,Lopez-Otin, C(2008).Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.Cancer Res,68,2755-2763.
  13. Helicobacter, Cancer Collaborative G(2001).Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts.Gut,49,347-353.
  14. Hu, PS,Chang, WS,Chou, AK,Hsia, NY,Hung, YW,Lin, CW,Wu, CW,Huang, CY,Wu, MF,Liao, CH,Tsai, CW,Bau, DT,Gong, CL(2018).The association of MMP-8 genotypes with pterygium.In Vivo,32,41-46.
  15. Hu, Z,Huo, X,Lu, D,Qian, J,Zhou, J,Chen, Y,Xu, L,Ma, H,Zhu, J,Wei, Q,Shen, H(2005).Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer.Clin Cancer Res,11,5433-5439.
  16. Hung, YW,Tsai, CW,Wu, CN,Shih, LC,Chen, YY,Liu, YF,Hung, HS,Shen, MY,Chang, WS,Bau, DT(2017).The contribution of matrix metalloproteinase-8 promoter polymorphism to oral cancer susceptibility.In Vivo,31,585-590.
  17. Ji, HX,Chang, WS,Tsai, CW,Wang, JY,Huang, NK,Lee, AS,Shen, MY,Chen, WY,Chiang, YC,Shih, TC,Hsu, CM,Bau, DT(2015).Contribution of DNA repair xeroderma pigmentosum group D genotype to gastric cancer risk in Taiwan.Anticancer Res,35,4975-4981.
  18. Kim, MH,Albertsson, P,Xue, Y,Nannmark, U,Kitson, RP,Goldfarb, RH(2001).Expression of neutrophil collagenase (MMP-8) in Jurkat T leukemia cells and its role in invasion.Anticancer Res,21,45-50.
  19. Kim, YH,Jung, JC,Gum, SI,Park, SB,Ma, JY,Kim, YI,Lee, KW,Park, YJ(2017).Inhibition of pterygium fibroblast migration and outgrowth by bevacizumab and cyclosporine a involves down-regulation of matrix metalloproteinases-3 and -13..PLoS One,12,e0169675.
  20. Kuo, HW,Huang, CY,Fu, CK,Liao, CH,Hsieh, YH,Hsu, CM,Tsai, CW,Chang, WS,Bau, DT(2014).The significant association of CCND1 genotypes with gastric cancer in Taiwan.Anticancer Res,34,4963-4968.
  21. Kuo, WH,Huang, CY,Fu, CK,Hsieh, YH,Liao, CH,Hsu, CM,Huang, YK,Tsai, CW,Chang, WS,Bau, DT(2014).Effects of interleukin-10 polymorphisms and smoking on the risk of gastric cancer in Taiwan.In Vivo,28,967-971.
  22. Lai, CY,Chang, WS,Hsieh, YH,Hsu, CM,Tsai, CW,Chen, AC,Wang, CH,Bau, DT(2016).Association of tissue inhibitor of metalloproteinase-1 genotypes with lung cancer risk in Taiwan.Anticancer Res,36,155-160.
  23. Laitinen, A,Hagstrom, J,Mustonen, H,Kokkola, A,Tervahartiala, T,Sorsa, T,Bockelman, C,Haglund, C(2018).Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer.Tumour Biol,40,1010428318799266.
  24. Lee, SG,Kim, B,Choi, J,Kim, C,Lee, I,Song, K(2002).Genetic polymorphisms of XRCC1 and risk of gastric cancer.Cancer Lett,187,53-60.
  25. Liao, CH,Chang, WS,Hu, PS,Wu, HC,Hsu, SW,Liu, YF,Liu, SP,Hung, HS,Bau, DT,Tsai, CW(2017).The contribution of MMP-7 promoter polymorphisms in renal cell carcinoma.In Vivo,31,631-635.
  26. Lin, CH,Lin, CC,Tsai, CW,Chang, WS,Yang, CW,Bau, DT(2014).Association of caveolin-1 genotypes with gastric cancer in Taiwan.Anticancer Res,34,2263-2267.
  27. Lin, Y,Liu, J,Jin, L,Jiang, Y(2017).Polymorphisms in matrix metalloproteinases 2, 3, and 8 increase recurrence and mortality risk by regulating enzyme activity in gastric adenocarcinoma.Oncotarget,8,105971-105983.
  28. Liu, B,Yi, M,Tang, Y,Liu, Q,Qiu, H,Zou, Y,Peng, P,Zhang, L,Hu, C,Yuan, X(2016).MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.Oncotarget,7,70175-70184.
  29. Liu, L,Wu, J,Wu, C,Wang, Y,Zhong, R,Zhang, X,Tan, W,Nie, S,Miao, X,Lin, D(2011).A functional polymorphism (-1607 1G-->2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer.Cancer,117,5172-5181.
  30. Lukashev, ME,Werb, Z(1998).ECM signalling: orchestrating cell behaviour and misbehaviour.Trends Cell Biol,8,437-441.
  31. Montel, V,Kleeman, J,Agarwal, D,Spinella, D,Kawai, K,Tarin, D(2004).Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.Cancer Res,64,1687-1694.
  32. Park, CC,Bissell, MJ,Barcellos-Hoff, MH(2000).The influence of the microenvironment on the malignant phenotype.Mol Med Today,6,324-329.
  33. Parkin, DM(2004).International variation.Oncogene,23,6329-6340.
  34. Pulukuri, SM,Rao, JS(2008).Matrix metalloproteinase-1 promotes prostate tumor growth and metastasis.Int J Oncol,32,757-765.
  35. Shen, TC,Hsia, TC,Chao, CY,Chen, WC,Chen, CY,Chen, WC,Lin, YT,Hsiao, CL,Chang, WS,Tsai, CW,Bau, DT(2017).The contribution of MMP-8 promoter polymorphisms in lung cancer.Anticancer Res,37,3563-3567.
  36. Sun, KT,Tsai, CW,Chang, WS,Shih, LC,Chen, LY,Tsai, MH,Ji, HX,Hsiao, CL,Liu, YC,Li, CY,Bau, DT(2016).The contribution of matrix metalloproteinase-1 genotype to oral cancer susceptibility in Taiwan.In Vivo,30,439-444.
  37. Tsai, CW,Chang, WS,Gong, CL,Shih, LC,Chen, LY,Lin, EY,Li, HT,Yen, ST,Wu, CN,Bau, DT(2016).Contribution of matrix metallopeptidase-1 genotypes, smoking, alcohol drinking and areca chewing to nasopharyngeal carcinoma susceptibility.Anticancer Res,36,3335-3340.
  38. Tsai, YY,Chiang, CC,Yeh, KT,Lee, H,Cheng, YW(2010).Effect of TIMP-1 and MMP in pterygium invasion.Invest Ophthalmol Vis Sci,51,3462-3467.
  39. Vincenti, MP,White, LA,Schroen, DJ,Benbow, U,Brinckerhoff, CE(1996).Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability.Crit Rev Eukaryot Gene Expr,6,391-411.
  40. Wang, H,Parry, S,Macones, G,Sammel, MD,Ferrand, PE,Kuivaniemi, H,Tromp, G,Halder, I,Shriver, MD,Romero, R,Strauss, JF, 3rd(2004).Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM).Hum Mol Genet,13,2659-2669.
  41. Yang, MD,Wang, HC,Chang, WS,Tsai, CW,Bau, DT(2011).Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan.BMC Cancer,11,174.
  42. Yang, SF,Lin, CY,Yang, PY,Chao, SC,Ye, YZ,Hu, DN(2009).Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C.Invest Ophthalmol Vis Sci,50,4588-4596.
  43. Yu, C,Zhou, Y,Miao, X,Xiong, P,Tan, W,Lin, D(2004).Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer.Cancer Res,64,7622-7628.
print cancel