Effect of High Calcium Diet on Cadmium-Induced Hypertension in Rat

含有高鈣的食品在老鼠體內對由鎘誘起之高血壓的影響

10.6452/KJMS.199204.0189

陳克紹(Keh-Shaw Chen)

calcium diet hypertension

The Kaohsiung Journal of Medical Sciences

8卷4期（1992 / 04 / 01）

189 - 194

英文

在日本曾有因為環境污染導致鎘中毒事件之報導。鎘中毒的病理現象是高血壓。在動物體內的研究，當Cd2+口服餵給老鼠後，是否導致高血壓有長期的爭論。但是一般而言，長期的腹膜內注射CdCl2是會誘起高血壓。鈣離子（Ca2+）在血管收縮方面擔任的角色是無可置疑。含有高鈣的食品在高血壓狀態下的人類和動物都可減低血壓，雖然其抗高血壓活性的機轉還不很清楚。本研究在探討含有高鈣的食品對長期腹膜內注射CdCl2誘起的高血壓之影響。腹膜內注射CdCl2溶液（0.5和1.0 mg / kg / day）到雌鼠體內，連續二週後，導至平均血壓上昇。兩側腎上腺切除術不能防止CdC12誘起的高血壓，但是餵食含有高鈣的食品（4 % wt / wt）之老鼠體中卻沒有發現CdC12誘起的血壓上昇現象。施與含有高鈣的食品不會影響正常老鼠的血壓和體重。因此得到以下的結論：含有高鈣的食品在老鼠體中可防上CdCl2誘起的高血壓之發生。

Effect of high calcium diet on the formation of hypertension induced by chronic cadmium chloride (CdCI2) treatment was investigated in Wistar rats. Intraperitoneal injection of CdC12 solution (0.5 and 1.0 mg/kg/day) into female rats for two weeks resulted in an elevation of mean blood pressure. Bilateral adrenalectomy failed to prevent the CdCI2-induced hypertension. However, elevation of blood pressure from CdCI2 was not be found in rats on high calcium diet (4%Wt/Wt). Administration of high calcium diet influenced neither the blood pressure nor body weight of normal rats. My results suggest that high calcium diet may prevent the development of CdCI2-induced hypertension in rats.