I-131 NP-59 Adrenal Cortical Scintigraphy in Suspected primary Aldosteronism

以I-131 NP-59腎上腺皮質閃爍造影術評估疑似原發性醛類酯過多症

10.6452/KJMS.199204.0213

高嘉鴻(Chia-Hung Kao)；廖澍昆(Shu-Quinn Liao)；王世楨(Shyh-Jen Wang)；林明賢(Ming-Shyan Lin)；許忠源(Chung-Yuan Hsu)；林萬鈺(Wan-Yu Lin)

1-131 NP-59 adrenal cortical scintigraphy ； primary aldosteronism

The Kaohsiung Journal of Medical Sciences

8卷4期（1992 / 04 / 01）

213 - 218

英文

自1983年5月至1990年6月間，本院35位疑似原發性醛類脂醇過多症（P rimary aldosteronism）患者，接受Dexamethasone壓抑性I-131 NP-59腎上腺皮質閃爍造影。其結果與臨床，生化，放射線及病理資料做比較，比評估使用I-131 NP-59腎上腺皮質閃爍造影診斷原發性醛類脂醇過多症之正確性；結果並依真陽性，真陰性，偽陽性和偽陰性的比例來檢討。所得到的診斷之靈敏度為78.9 %，專一性為100 %，陽性預測正確率為100 %，陰性預測正確率為80％。此結果顯示I-131 NP-59腎上腺皮質閃爍造影對於疑似原發性醛類脂醇過多症之診斷，提供一正確而不具侵犯性的方法。

Dexamethasone suppression [Iodine-131] 6-Beta-Iodomethyl-19-Norchole- sterol (1-131 NP-59) adrenal cortical scintigraphy was performed in 35 patients with suspected primary aldosteronsim, between May 1983 and June 1990. Based on clinical, biochemical, radiographic and pathologic data, the diagnostic accuracy of primary aldosteronism from 1-131 NP-59 adrenal cortical scintigraphy was evaluated. The sensitivity, specificity, positive predictive accuracy and negative predictive accuracy was 78.9%, 100%, 100% and 80% respectively. We conclude that 1-131 NP-59 adrenal cortical scintigraphy is an accurate and non- invasive technique for the diagnosis of suspected primary aldosteronism.