Incidence and Antimicrobial Resistance of Salmonella Serotypes in Southern Taiwan from 1978 Through 1987

南台灣地區沙門氏桿菌的血清型及其抗藥性（1978~1987）

10.6452/KJMS.199205.0247

彭健芳(Chien-Fang Peng)

Salmonella ； serotypes ； antimicrobial resistance

The Kaohsiung Journal of Medical Sciences

8卷5期（1992 / 05 / 01）

247 - 254

英文

於1978年到1987年之間，從南台灣地區共分離3,269株沙門氏桿菌。經過血清學的分型鑑定。常見的前十種是S. typhimurium，(43.7%)，S. muenchen (13.7%)， S. panama (9.0%)，S. krefeld (8.1%)，S. bovis-morbificans (6.3%)，S. derby (4.0%)， S.anatum (2.7%)，S. bra-enderup (1.6%)，S. typhi (1.2%)，和S. dumfries (0.7%)。由體外活性試驗結果，Norfloxacin可以抑制全部所分離的沙門氏桿菌的菌株。Moxalactam和cefotaxime亦有 96%~100%的抑制力。Nalidixic acid和trimethoprim-sulfamethoxazole則有81~100%的活性，但對S. bovis-morbificans和S. typhimurium二種株例外。一般而言，S. typhimurium具有較高而且多種藥物的抗藥性。在1,430的S. typhimurium中，有158株具有多重的抗藥性，其中包括有ampicillin，amikacin，carbenicillin，cephalothin，chloramphenicol，gentamicin， kanamycin，tetrancycline和trimethoprim-sulfamethoxazole。但我們所分離的S. typhi則表現出對所有藥物都具敏感性。

A total of 3,269 Salmonella strains, isolated from patients suffering from salmonellosis, was diveided into 43 different serotypes during the period between 1978 and 1987. The commonest ten serotypes in the order of prevalence were S. typhimurium (43.7%), S. muenchen (13.7%), S. panama (9.0%), S. krefeld (8.1%), S. bovis-morbificans (6.3%), S. derby (4.0%), S.anatum (2.7%), S. bra-enderup (1.6%), S. typhi (1.2%), and S. dumfries (0.7%). Norfloxacin was found highly effective against Salmonella isolates in vitro. Moxalactam and cefotaxime were more effective than cephalothin against strains tested. Nalidixic acid and trimethoprim-sulfamethoxazole inhibited 81-100%strains of Salmonella isolates, except S. bovis-morbificans and S. typhimurium. In general, S. typhimurium showed high incidence of multiple drug resistance. Among 1,430 strains of S. typhimurium, 158 isolates showed a uniquely high level resistance to a number of antimicrobial agents, including ampicillin, amikacin, carbenicillin, cephalothin, chloramphenicol, gentamicin, kanamycin, tetrancycline and trimethoprim-sulfamethoxazole. It was noted that all S. typhi isolates in this study were sensitive to all drugs tested.