Optimal Insemination Concentration for Human in vitro Fertilization (IVF)

Wan-Song A. Wun；Chuan-Chuan C. Wun；Cecilia T. Valdes；Randall C. Dunn；George M. Grunert

fertilization ； implantation ； human IVF ； lateral head displacement ； Kruger morphology ； hypo-osmotic swelling test

The Chinese Journal of Physiology

40卷4期（1997 / 12 / 01）

227 - 236

英文

This study is looking for optimal insemination concentration to achieve optimal IVF pregnancy. Sperm lateral head displacement, total abnormal form, Kruger morphology and index, hypo-osmotic swelling test were significantly correlated with fertilization in vitro. Based on those parameters, logistic regression models were formulated. These models predict either fertilization probability provided with an insemination concentration or insemination concentration assigned with a definite fertilization percentage. These models showed that increased insemination concentration can increase fertilization percentage. The increase of fertilization didn’t compensate for the significant loss of implantation by increasing insemination concentration.