Effects of Prostaglandins E2 and F(subscript 2a) (PGE2; PGF(subscript 2a), Trilostane, Mifepristone, Palmitic Acid(PA), Indomethacin(INDO), Ethamoxytriphetol(MER-25), PGE2+PA, or PGF(subscript 2a)+PA

Y. S. Weems；A.W.Lewis；R. D. Randel；C. W. Weems

cow ； PGE2 ； PGF(subscript 2a) ； progesterone ； RU-486 ； palmitic acid ； indomethacin ； MER-25 ； corpus luteum ； pregnancy

The Chinese Journal of Physiology

45卷4期（2002 / 12 / 31）

163 - 168

英文

The effects of PGE2, PGF(subscript 2a), trilostane, RU-486, PA, INDO, MER-25, PGE2, or PGF(subscript 2a)+PA on secretion of progesterone, PGE2, or PGF(subscript 2a) by bovine corpora lutea(CL) of mid-pregnancy in vitro for 4 and 8 hr was examined. Secretion of PGE2 and PGF(subscript 2a) increased with time in culture (P≤0.05). PGE2 and PGE2+PA increased(P≤0.05) secretion of progesterone at 4 and 8 h, progesterone secretion was increased (P≤0.05)at 4h; but not at 8h(P≥0.05) by trilostane, mifepristone, PGF(subscript 2a) and PGF(subscript 2a)+PA, and was decreased at 8 h by PGF(subscript 2a) and PGF(subscript 2a)+PA. Indomethacin decreased (P≤0.05) secretion of PGE2, PGF(subscript 2a), and progesterone at 4 and 8 h. Trilostane, PA, PGF(subscript 2a), RU-486 and PGF(subscript 2a)+PA increased(P≤0.05 PGE2 at 4 h only. Palmitic acid decreased(P≤0.05) PGF(subscript 2a) at 4h, while trilostane, RU-486, or MER-25 did not affect(P≤0.05) PGE2 of PGF(subscript 2a) secretion. It is concluded that PGE2 of luteal tissue origin is the luteotropin at mid-pregnancy in cows. Also, it is suggested that PA may alter progesterone secretion by affecting the inter conversion of PGE2 and PGF(subscript 2a).