Effects of Amphetamine on Schedule-Induced Polydipsia

Yia-Ping Liu；Hung-Chin Wang；Ching-Jiunn Tseng；Hung-Shan Tang；Tsai-Hsin Yin；Che-Se Tung

amphetamine ； schedule-induced polydipsia ； locomotor activity ； stereotyped behavior ； behavioral competition ； stress coping strategy

The Chinese Journal of Physiology

48卷4期（2005 / 12 / 31）

176 - 186

英文

A series of experiments examined the effects of amphetamine (AMPH) at various doses administration for different length of time on a schedule-induced polydipsia (SIP) and possible associations with behavioral activation. Two stages of a two-eek AMPH treatment ere introduced with interposed interval of two months. In terms of behavioral activation, AMPH induced a robust depression across stages but with less potency in the second one. As for the SIP performance, the effects manifested qualitative difference in the two stages. For the first stage, there were no differential effects of AMPH on stereotypy intensity during the facultative phase of the inter-rewarding interval. However, AMPH reduced the high frequency of licks in the adjunctive (schedule-induced) phase and increased the low frequency of nose pokes in the terminal (schedule-dependent) phase. In the second stage, AMPH had no effect on the frequency of licking whereas the efficiency of licking and the frequency of nose pokes ere reduced. These results ere interpreted to support the current vie point that the behavior of SIP displaying is relevant to the function of central dopaminergic systems. The results ere further discussed in the considerations of behavioral competition, stress coping strategy, and also the impact of AMPH at different time.

1. Adani, N.,Kiryati, N.,Golani, I.(1991).The description of rat drug-induced behavior: kinematics versus response categories.Neurosci. Biobehav. Rev.,15,455-460.
2. Badiani, A.,Camp, D.M.,Robinson, T.E.(1997).Enduring enhancement of amphetamine sensitization by drug-associated environmental stimuli.J. Pharmacol. Exp. Ther.,282,787-794.
3. Barr, A.M.,Phillips, A.G.(1999).Withdrawal following repeated exposure to d-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement.Psychopharmacology (Berl),141,99-106.
4. Brett, L.P.,Levine, S.(1981).The pituitary-adrenal response to "minimized" schedule-induced drinking.Physiol. Behav.,26,153-158.
5. Brett, L.P.,Levine, S.(1979).Schedule-induced polydipsia suppresses pituitary-adrenal activity in rats.J. Comp. Physiol. Psychol,93,946-956.
6. Cabib, S.,Bonaventura, N.(1997).Parallel strain-dependent susceptibility to environmentally-induced stereotypies and stressinduced behavioral sensitization in mice.Physiol. Behav.,61,499-506.
7. Cho, A.K.,Melega, W.P.(2002).Patterns of methamphetamine abuse and their consequences.J. Addict. Dis.,21,21-34.
8. Dantzer, R.,Terlouw, C.,Mormede, P.,Le Moal, M.(1988).Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels.Physiol. Behav.,43,275-279.
9. Didriksen, M.,Christensen, A.V.(1994).The effects of amphetamine, phencyclidine, dopaminergic antagonists and atypical neuroleptics on schedule-induced polydipsia (SIP) are distinguishable.Behav. Pharmacol,5,32-41.
10. Ellinwood, E.H., Jr.,Balster, R.L.(1974).Rating the behavioral effects of amphetamine.Eur. J. Pharmacol,28,35-41.
11. Falk, J.L.(1969).Conditions producing psychogenic polydipsia in animals.Ann. N.Y. Acad. Sci.,157,569-593.
12. Falk, J.L.(1971).The nature and determinants of adjunctive behavior.Physiol. Behav.,6,577-588.
13. Falk, J.L.(1961).Production of polydipsia in normal rats by an intermittent food schedule.Science,133,195-196.
14. Fray, P.J.,Sahakian, B.J.,Robbins, T.W.,Koob, G.F.,Iversen, S.D.(1980).An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.Psychopharmacology (Berl),69,253-259.
15. Grilly, D.(1997).Rate-dependent effects of amphetamine resulting from behavioral competition.Biobehav. Rev.,1,87-93.
16. Hall, F.S.(1998).Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences.Crit. Rev. Neurobiol,12,129-162.
17. Hand, T.H.,Franklin, K.B.(1983).The influence of amphetamine on preference for lateral hypothalamic versus prefrontal cortex or ventral tegmental area self-stimulation.Pharmacol. Biochem. Behav.,18,695-599.
18. Hinson, J.M.,Staddon, J.E.(1978).Behavioral competition: a mechanism for schedule interactions.Science,202,432-434.
19. Hu, W.C.,Lai, C.Y.,Shyu, L.Y.,Tung, C.S.(1998).A methodological improvement and system validation to obtain precise behavioral parameters for schedule-induced polydipsia.Chinese J. Physiol,41,9-17.
20. Kaplan, H.I.,Sadock, B.J.,Grebb, J.A.(1994).Synopsis of Psychiatry.Maryland:Williams & Wilkins.
21. Koelega, H.S.(1993).Stimulant drugs and vigilance performance: a review.Psychopharmacology (Berl),111,1-16.
22. Kokkinidis, L.,Zacharko, R.M.,Anisman, H.(1986).Amphetamine withdrawal: a behavioral evaluation.Life Sci.,38,1617-1623.
23. Lago, J.A.,Kosten, T.R.(1994).Stimulant withdrawal.Addiction,89,1477-1481.
24. Levine, R.,Levine, S.(1989).Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia.Behav. Neurosci,103,621-637.
25. Little, J.D.,Romans, S.E.(1993).Psychosis following readministration of diethyl proprion: a possible role for kindling?.Int. Clin. Psychopharmacol,8,67-70.
26. Liu, Y.P.(2002).A dissertation submitted to the University of Cambridge for the degree of Doctor of Philosophy.
27. Liu, Y.P.,Chiang, C.P.,Tseng, C.J.,Huang, N.K.,Yin, T.H.,Tung, C.S.(1996).Morphine withdrawal and schedule-induced polydipsia.Chinese J. Physiol,39,219-225.
28. MacLennan, A.J.,Maier, S.F.(1983).Coping and the stress-induced potentiation of stimulant stereotypy in the rat.Science,219,1091-1093.
29. Malinowski, P.,Hubner, R.,Keil, A.,Gruber, T.(2002).The influence of response competition on cerebral asymmetries for processing hierarchical stimuli revealed by ERP recordings.Exp. Brain. Res.,144,136-139.
30. Martin-Iverson, M.T.,Wilkie, D.,Fibiger, H.C.(1987).Effects of haloperidol and d-amphetamine on perceived quantity of food and tones.Psychopharmacology (Berl),93,374-381.
31. Mittleman, G.,Rosner, A.L.,Schaub, C.L.(1994).Polydipsia and dopamine: behavioral effects of dopamine D1 and D2 receptor agonists and antagonists.J. Pharmacol. Exp. Ther.,271,638-650.
32. Mittleman, G.,Whishaw, I.Q.,Jones, G.H.,Koch, M.,Robbins, T.W.(1990).Cortical, hippocampal, and striatal mediation of schedule-induced behaviors.Behav. Neurosci,104,399-409.
33. Paulson, P.E.,Robinson, T.E.(1996).Regional differences in the effects of amphetamine withdrawal on dopamine dynamics in the striatum-Analysis of circadian patterns using automated on-line microdialysis.Neuropsychopharmacology,14,325-337.
34. Pierce, R.C.,Kalivas, P.W.(1997).A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants.Brain Res. Brain. Res. Rev.,25,192-216.
35. Pijlman, F.T.,van Ree, J.M.(2002).Physical but not emotional stress induces a delay in behavioral coping responses in rats.Behav. Brain. Res.,136,365-373.
36. Pitman, R.K.(1989).Animal models of compulsive behavior.Biol. Psychiatry,26,189-198.
37. Pulvirenti, L.,Koob, G.F.(1994).Dopamine receptor agonists, partial agonists and psychostimulant addiction.Trends. Pharmacol. Sci.,15,374-379.
38. Reid, A.K.,Staddon J.E.R.,Cooper, S.J.,Dourish C.T.(edited)(1990).Neurology of stereotyped behaviour.Oxford:Claredon Press.
39. Ripley, T.L.,Dunworth, S.J.,Stephens, D.N.(2002).Consequences of amygdala kindling and repeated withdrawal from ethanol on amphetamine-induced behaviours.Eur. J. Neurosci,16,1129-1138.
40. Robbins, T.W.,Mittelman, G.,O` Brien, J.,Winn, P.,Cooper, S.J.,Dourish C.T.(edited)(1990).Neurology of stereotyped behaviour.Oxford:Claredon Press.
41. Robbins, T.W.,Roberts, D.C.,Koob, G.F.(1983).Effects of damphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamineinduced lesions of the nucleus accumbens.J. Pharmacol. Exp. Ther.,224,662-673.
42. Robinson, T.E.,Angus, A.L.,Becker, J.B.(1985).Sensitization to stress: the enduring effects of prior stress on amphetamineinduced rotational behavior.Life Sci.,37,1039-1042.
43. Robinson, T.E.,Berridge, K.C.(1993).The neural basis of drug craving: an incentive-sensitization theory of addiction.Brain. Res. Brain Res. Rev.,18,247-291.
44. Ryan, C.N.,Evenden, J.L.,Petterson, M.(1993).Effects of buspirone and ipsapirone on schedule induced polydipsia: comparison with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and raclopride.Psychopharmacology (Berl),112,34-44.
45. Sadock, B.J.,Sadock V.A.Wilkins, W.(edited)(2003).Synopsis of psychiatry.New York:Williams & Wilkins.
46. Sahakian, B.J.,Robbins, T.W.,Morgan, M.J.,Iversen, S.D.(1975).The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats.Brain Res.,84,195-205.
47. Schiorring, E.(1981).Psychopathology induced by "speed drugs".Pharmacol. Biochem. Behav.,14(Suppl 1),109-122.
48. Schuckit, M.A.(1994).The treatment of stimulant dependence.Addiction,89,1559-1563.
49. Segal, D.S.,Mandell, A.J.(1974).Long-term administration of damphetamine: progressive augmentation of motor activity and stereotypy.Pharmacol. Biochem. Behav.,2,249-255.
50. Shaner, A.(1999).Delusions, superstitious conditioning and chaotic dopamine neurodynamics.Med. Hypotheses,52,119-123.
51. Sharp, T.,Zetterstrom, T.,Ljungberg, T.,Ungerstedt, U.(1987).A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis.Brain Res.,401,322-330.
52. Srisurapanont, M.,Kittiratanapaiboon, P.,Jarusuraisin, N.(2001).Treatment for amphetamine psychosis.Cochrane Database Syst. Rev..
53. Tadokoro, S.,Kuribara, H.(1990).Modification of the behavioral effects of drugs after repeated administration-special reference to the reverse tolerance of amphetamines.Nippon Yakurigaku Zasshi,95,229-238.
54. Tung, C.S.,Wu, W.H.,Tseng, C.J.,Yin, T.H.(1994).Effects of amperozide on schedule-induced polydipsia in rats.Eur. J. Pharmacol,256,193-200.
55. Tung, C.S.,Yin, T.H.,Wayner, M.J.,Barone, F.C.(1980).Effects of subdiaphragmatic vagotomy on schedule induced drinking and schedule dependent lever pressing.Physiol. Behav.,25,745-751.
56. Weiss, F.,Imperato, A.,Casu, M.A.,Mascia, M.S.,Gessa, G.L.(1997).Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats.Eur. J. Pharmacol,337,219-222.
57. Wylie, G.R.,Javitt, D.C.,Foxe, J.J.(2003).Cognitive control processes during an anticipated switch of task.Eur. J. Neurosci,17,667-672.
58. Yui, K.,Ishiguro, T.,Goto, K.,Ikemoto, S.,Kamata, Y.(1999).Spontaneous recurrence of methampetamine psychosis: increased sensitivity to stress associated with noradrenergic hyperactivity and dopaminergic change.Eur. Arch. Psychiatry Clin. Neurosci,249,103-111.

1. Wang, Pei-Ying,Tung, Che-Se,Liu, Yia-Ping,Huang, Chuen-Lin,Chang, Shang-Tang,Wang, Pei-Ying,Tung, Che-Se,Liu, Yia-Ping,Huang, Chuen-Lin,Chang, Shang-Tang(2013).Implication of Cerebral Dopamine-ß Hydroxylase for Cardiovascular and Mood Regulation in Rats.中國生理學雜誌,56(4),209-218.
2. Yang, Szu-Nian,Wang, Ying-Hsiu,Tung, Che-Se,Liu, Yia-Ping,Ko, Chih-Yuan(2015).Effects of Escitalopram on a Rat Model of Persistent Stress-Altered Hedonic Activities: Towards a New Understanding of Stress and Depression.中國生理學雜誌,58(6),404-411.
3. Yang, Szu-Nian,Wang, Ying-Hsiu,Tung, Che-Se,Liu, Yia-Ping,Ko, Chih-Yuan(2015).Effects of Escitalopram on a Rat Model of Persistent Stress-Altered Hedonic Activities: Towards a New Understanding of Stress and Depression.中國生理學雜誌,58(6),404-411.