Effect of a Two-month Detraining on Glucose Tolerance and Insulin Sensitivity in Athletes-link to Adrenal Steroid Hormones

Pin-Tai Wang；I-Tsun Chiang；Chih-Yuan Lin；Chien-Wen Hou；Chung-Yu Chen；Hsing-Hao Lee；Wei-Hsiang Chang；Chia-Hua Kuo

physical inactivity ； obesity ； insulin resistance ； hyperinsulinemia ； cortisol ； DHEA-S

The Chinese Journal of Physiology

49卷5期（2006 / 10 / 31）

251 - 257

英文

Reduction in physical activity has been demonstrated to associate with the increased risk in insulin resistance and type 2 diabetes. To determine whether alteration in insulinemia, due to abstention from regular exercise training, is associated with changes in serum dehydroepiandrosterone sulfate (DHEAS) and cortisol, 18 highly trained badminton players (21.2±0.3 years) were enrolled into a 2-month detraining study. Fasting serum insulin, glucose, DHEA-S, and cortisol were determined at trained state and at day 60 of detraining. Glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test (OGTT). The 2-month detraining increased fasting glucose and insulin concentrations and body weight slightly, but did not significantly affect glucose tolerance and insulin response curve, in which 10 subjects had increased and 8 subjects had slightly decreased in the area under curve for insulin (IAUC). In the subjects with increased IAUC, serum cortisol was also elevated (from 0.44±0.07 to 0.83±0.26 U/l, P＜0.05) in parallel, and serum creatine kinase (CK) was unaltered during detraining. Whereas in the subjects with decreased IAUC, serum cortisol (from 0.51±0.19 to 0.54±0.14 U/l, no significance) was not changed and serum creatine kinase (from 461±179 to 151±21 U/l) was decreased during detraining. Two groups of detrained subjects exhibited a similar reduction in serum DHEA-S levels and slight elevation in body weight. The novel finding of the study is that the changes in serum cortisol, but not DHEA-S, were associated with the change in insulin sensitivity during early phase of lifestyle change from physically active to sedentary, and this response appears to be varied individually among athletes.

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