Transfer Function Analysis of Heart Rate Variability Correlated with Gastric Myoelectrical Activity Using a Liquid Nutritional Meal Compared to Water: Are They Different?

Chien-Lin Chen；Cheryl C. H. Yang；Terry B. J. Kuo

autonomic nervous system ； gastric myoelectrical activity ； heart rate ； respiration

The Chinese Journal of Physiology

50卷6期（2007 / 12 / 01）

271 - 276

英文

We aimed to investigate difference in the effects of water and a liquid nutritional meal on the parasympathetic and gastric myoelectrical activities. The study was a repeated-measures design in which each subject was presented with 500 ml of water and a liquid nutritional meal (Ensure(superscript ®)) on two separate and random sessions. The electrogastrography (EGG) and electrocardiogram were simultaneously recorded in 16 healthy subjects. There were no significant changes in the EGG-3 cycle per minute (cpm) power, any HRV variable, or the transfer function magnitude after Ensure(superscript ®) intake. Water ingestion resulted in a significant increase in both the EGG-3 cpm power and the transfer magnitude compared to Ensure(superscript ®) intake (P＜0.05). The effects of water and Ensure(superscript ®)on the parasympathetic and gastric electric activities are different, in which the latter is less likely to provoke an autonomic response after gastric stimulation.

1. Abell, T. L.,Malagelada, J. R.(1985).Glucagon-evoked gastric dysrhythmias in humans shown by an improved electrogastrographic technique.Gastroenterology,88,1932-1940.
2. Appel, M. L.,Berger, R. D.,Saul, J. P.,Smith, J. M.,Cohen, R. J.(1989).Beat to beat variability in cardiovascular variables: noise or music?.J. Am. Coll. Cardiol,14,1139-1148.
3. Berger, R. D.,Saul, J. P.,Cohen, R. J.(1989).Transfer function analysis of autonomic regulation. I. Canine atrial rate response.Am. J. Physiol.,256,142-152.
4. Chen, C. L.,Lin, H. H.,Orr, W. C.,Yang, C. C. H.,Kuo, T. B. J.(2004).Transfer function analysis of heart rate variability in response to water intake: correlation with gastric myoelectrical activity.J. Appl. Physiol.,96,2226-2230.
5. Chen, J. D.,McCallum, R. W.(1994).Electrogastrography: Principles and Applications.New York:Raven Press.
6. Chen, J. D.,Pan, J.,McCallum, R. W.(1995).Clinical significance of gastric myoelectrical dysrhythmias.Dig. Dis.,13,275-290.
7. Chen, J.,McCallum, R. W.(1992).Effect of milk on myoelectrical activity of the stomach—an electrogastrographic study.Med. Biol. Eng. Comput,30,564-567.
8. Chen, J.,McCallum, R. W.(1991).Response of the electric activity in the human stomach to water and a solid meal.Med. Biol. Eng. Comput,29,351-357.
9. Clevers, G. J.,Smout, A. J.,Van der Schee, E. J.,Akkermans, L. M.(1991).Myo-electrical and motor activity of the stomach in the first days after abdominal surgery: evaluation by electrogastrography and impedance gastrography.J. Gastroenterol. Hepatol.,6,253-259.
10. deBoer, R. W.,Karemaker, J. M.,Strackee, J.(1987).Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model.Am. J. Physiol,253,680-689.
11. Fouad, F. M.,Tarazi, R. C.,Ferrario, C. M.,Fighaly, S.,Alicandri, C.(1984).Assessment of parasympathetic control of heart rate by a noninvasive method.Am. J. Physiol,246,838-842.
12. Geldof, H.,van der Schee, E. J.,Smout, A. J. P. M.,Van de Merwe, J. P.,van Blankenstein, M.,L., G. J.(1989).Myoelectrical activity of the stomach in gastric ulcer patients: An electrogastrographic study.J. Gastrointestinal Motil,1,122-130.
13. Geldof, H.,van der Schee, E. J.,van Blankenstein, M.,Grashuis, J. L.(1986).Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting.Gut,27,799-808.
14. Hamilton, J. W.,Bellahsene, B. E.,Reichelderfer, M.,Webster, J. G.,Bass, P.(1986).Human electrogastrograms. Comparison of surface and mucosal recordings.Dig. Dis. Sci.,31,33-39.
15. Hinder, R. A.,Kelly, K. A.(1977).Human gastric pacesetter potential. Site of origin, spread, and response to gastric transection and proximal gastric vagotomy..Am. J. Surg.,133,29-33.
16. Kaneko, H.,Sakakibara, M.,Mitsuma, T.,Morise, K.(1995).Possibility of postprandial electrogastrography for evaluating vagal/nonvagal cholinergic activity in humans, through simultaneous analysis of postprandial heart rate variability and serum immunoreactive hormone levels.Am. J. Gastroenterol,90,603-609.
17. Koch, K. L.,Stewart, W. R.,Stern, R. M.(1987).Effect of barium meals on gastric electromechanical activity in man. A fluoroscopicelectrogastrographic study.Dig. Dis. Sci.,32,1217-1222.
18. Kuo, T. B. J.,Chern, C. M.,Sheng, W. Y.,Wong, W. J.,Hu, H. H.(1998).Frequency domain analysis of cerebral blood flow velocity and its correlation with arterial blood pressure.J. Cereb. Blood Flow Metab,18,311-318.
19. Kuo, T. B. J.,Lin, T.,Yang, C. C. H.,Li, C. L.,Chen, C. F.,Chou, P.(1999).Effect of aging on gender differences in neural control of heart rate..Am. J. Physiol.,277,2233-2239.
20. Kuo, T. B. J.,Shyr, M. H.,Chan, S. H. H.(1993).Simultaneous, continuous, on-line and real-time spectral analysis of multiple physiologic signals by a personal-computer-based algorithm..Biol. Signals,2,45-56.
21. Levanon, D.,Zhang, M.,Chen, J. D.(1998).Efficiency and efficacy of the electrogastrogram.Dig. Dis. Sci.,43,1023-1030.
22. Lu, C. L.,Zou, X.,Orr, W. C.,Chen, J. D.(1999).Postprandial changes of sympathovagal balance measured by heart rate variability.Dig. Dis. Sci.,44,857-861.
23. MacIntosh, C. G.,Horowitz, M.,Verhagen, M. A.,Smout, A. J.,Wishart, J.,Morris, H.,Goble, E.,Morley, J. E.,Chapman, I. M.(2001).Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men.Am. J. Gastroenterol.,96,997-1007.
24. Malliani, A.,Pagani, M.,Lombardi, F.,Cerutti, S.(1991).Cardiovascular neural regulation explored in the frequency domain.Circulation,84,482-492.
25. Montano, N.,Ruscone, T. G.,Porta, A.,Lombardi, F.,Pagani, M.,Malliani, A.(1994).Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt.Circulation,90,1826-1831.
26. Pagani, M.,Montano, N.,Porta, A.,Malliani, A.,Abboud, F. M.,Birkett, C.,Somers, V. K.(1997).Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans.Circulation,95,1441-1448.
27. Paraskevopoulos, J. A.,Houghton, L. A.,Eyre-Brooke, I.,Johnson, A. G.,Read, N. W.(1988).Effect of composition of gastric contents on resistance to emptying of liquids from stomach in humans.Dig. Dis. Sci.,33,914-918.
28. Quigley, J. P.,Zettelman, H. J.,Ivy, A. C.(1934).Analysis of the factors involved in gastric motor inhibition by fats..Am. J. Physiol.,108,643-651.
29. Saul, J. P.,Berger, R. D.,Albrecht, P.,Stein, S. P.,Chen, M. H.,Cohen, R. J.(1991).Transfer function analysis of the circulation: unique insights into cardiovascular regulation.Am. J. Physiol.,261,1231-1245.
30. Smout, A. J.,Van der Schee, E. J.,Grashuis, J. L.(1980).What is measured in electrogastrography?.Dig. Dis. Sci.,25,179-187.
31. Stern, R. M.,Crawford, H. E.,Stewart, W. R.,Vasey, M. W.,Koch, K. L.(1989).Sham feeding. Cephalic-vagal influences on gastric myoelectric activity.Dig. Dis. Sci.,34,521-527.
32. Stern, R. M.,Koch, K. L.,Stewart, W. R.,Vasey, M. W.(1987).Electrogastrography: current issues in validation and methodology..Psychophysiology,24,55-64.
33. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.(1996).Heart rate variability: standards of measurement, physiological interpretation, and clinical use..Circulation,93,1043-1065.
34. Uijtdehaage, S. H.,Stern, R. M.,Koch, K. L.(1992).Effects of eating on vection-induced motion sickness, cardiac vagal tone, and gastric myoelectric activity.Psychophysiology,29,193-201.
35. Vatner, S. F.,Franklin, D.,Van Citters, R. L.(1970).Mesenteric vasoactivity associated with eating and digestion in the conscious dog.Am. J. Physiol.,219,170-174.
36. Verhagen, M. A.,Rayner, C. K.,Andrews, J. M.,Hebbard, G. S.,Doran, S. M.,Samsom, M.,Horowitz, M.(1999).Physiological changes in blood glucose do not affect gastric compliance and perception in normal subjects.Am. J. Physiol.,276,761-766.