Acute Effects of the Cannabinoid Receptor Agonist WIN55212-2 on Dopamine Release in Rat: An In Vivo Electrochemical Study

Wun-Chin Wu；Yu Wang；Chok-Yung Chai

dopamine ； cannabinoid receptor ； striatum

The Chinese Journal of Physiology

51卷3期（2008 / 06 / 30）

152 - 159

英文

The aim of this study was to investigate the effects of the cannabinoid receptor agonist, WIN55212-2, and the cannabinoid receptor antagonist, SR141716A, on dopamine (DA) release evoked by KCl (120 mM) microinjected into the striatum. The cannabinoid agonist WIN55212-2 (1 and 5 mg/kg, i. p.) dosedependently attenuated DA release in the striatum, whereas the cannabinoid receptor antagonist SR141716A (3 mg/kg, i. p.) produced the opposite effect. SR141716A (3 mg/kg, i. p.) blocked the effects on DA release by WIN55212-2 (5 mg/kg, i. p.). Vehicle alone did not change DA release. These results suggest that cannabinoids modulate DA release in the striatum.

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