Effects of Alcohol on the Mouse-Killing Behavior of Olfactory Bulbectomized Rats

Chih-Yuan Chiang；Kuei-Ying Yeh；Shih-Fan Lin；Hung Hsuchou；Mei-Yun Tai；Ying-Jui Ho；Yuan-Feen Tsai

alcohol ； depression ； mouse-killing behavior ； olfactory bulbectomy

The Chinese Journal of Physiology

51卷6期（2008 / 12 / 01）

408 - 413

英文

The purpose of the current study was to evaluate the effects of chronic administration of alcohol on the olfactory bulbectomy (OBX)-induced mouse-killing behavior (MKB), an animal model for screening antidepressants. The rats were divided into three groups, which were given alcohol (0, 0.5, or 1 g/kg/day) orally for 28 days. MKB was analyzed before and at the end of each week of the alcohol treatment. The results showed that chronic alcohol treatment produced a significant increase in the latency of MKB, implying that alcohol may have an antidepressant-like activity. This suggests that alcohol dependence or abuse in depressed patients may result from ”self-medication”. Since it has been reported that OBX causes a decrease in the density of N-methyl-D-aspartate (NMDA) receptors in the brain and that alcohol is a potent and selective inhibitor of NMDA receptors, the possible role of NMDA receptors in this effect is discussed.

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