The Cooperative Phenomenon of Autonomic Nervous System in Urine Storage for Wistar Rats

10.4077/CJP.2009.AMH015

Shyang Chang；Meng-Ju Chiang；Shiun-Jeng Li；Shih-Jen Hu；Hsiu-Yao Cheng；Sheng-Hwu Hsieh；Chen-Li Cheng

autonomic nervous systems ； dynamical disease ； fractional Brownian motion ； micturition ； reciprocal innervations ； synergic co-activation ； urine storage

The Chinese Journal of Physiology

52卷2期（2009 / 04 / 01）

14 - 22

英文

The fractal dimension (FD) and spectral frequencies of physiological signals are two important indices in the study of physiological functions and dynamical diseases. The first index can be used to characterize the intensity and the second the rhythms of signals embedded in seemingly random data. Recent studies using both indices verified that synergic co-activations of bladder and external urethral sphincter (EUS) of Wistar rats were present during the voiding of urine. In this study, the primary aims were to (1) study if the involved muscles in the lower urinary tract would be under similar coactivations during the urine storage phase, and (2) characterize quantitatively the sympathetic and parasympathetic nerve activities simultaneously. Eighteen experiments were performed on six intact adult female Wistar rats and then the electromyogram of EUS and cystometrogram of bladder were analyzed. Results indicated that the EUS did not contain any significant spectral frequencies in the storage phase. Furthermore, its FDs (1.5918±0.0157) indicated that no appreciable amount of signal intensities was observed in the EUS. On the other hand, the bladder exhibited parasympathetic frequency of 8 Hz with signal-to-noise ratio (SNR)=19.9001 decibel (dB) for group mean, and sympathetic frequency of 19 Hz with SNR=22.8330 dB for group mean. In addition, its FDs (1.4796±0.0092) indicated relatively persistent intensities during storage as compared to that of EUS (1.5918±0.0157) with statistical significance (P＜0.01). We conclude that the EUS is not activated during the phase of storage. The bladder is under the cooperative, not antagonistic, sympathetic and parasympathetic nerve activities with discernible rhythmic frequencies and persistent intensities.

1. Chang, S.,Hsyu, M.C.,Cheng, H.Y.,Hsieh, S.H.(2008).Synergic coactivation of muscles in elbow flexion via fractional Brownian motion.Chinese J. Physiol.,51,376-386.
   連結：
2. Arneodo, A.,d''Aubenton-Carafa, Y.,Bacry, E.,Graves, P.V.,Muzy, J.F.,Thermes, C.(1996).Wavelet based fractal analysis of DNA sequences.Physica D,96,291-320.
3. Barrington, F.J.F.(1931).The component reflexes of micturition in the cat.Brain,54,177-188.
4. Billock, V.A.,de Guzman, G.C.,Scott Kelso, J.A.(2001).Fractal time and 1/f spectra in dynamic images and human vision.Physica D,148,136-146.
5. Chancellor, M.B.,Yoshimura, N.(2004).Neurophysiology of stress urinary incontinence.Rev. Urol.,6(3),19-28.
6. Chancellor, M.B.,Yoshimura, N.,Walsh, P.C. (edited)(2002).Campbell's Urology.Philadelphia, PA:Saunders.
7. Chang, S.,Hsyu, M.C.,Cheng, H.Y.,Hsieh, S.H.,Lin, C.C.(2008).Synergic coactivation in forearm pronation.Ann. Biomed. Eng..
8. Chang, S.,Hu, S.J.,Lin, W.C.(2004).Fractal dynamics and synchronization of rhythms in urodynamics of female Wistar rats.J. Neurosci. Meth.,139,271-279.
9. Chang, S.,Li, S.J.,Chiang, M.J.,Hu, S.J.,Hsyu, M.C.(2007).Fractal dimension estimation via spectral distribution function and its application to physiological signals.IEEE Trans. Biomed. Eng.,54,1895-1898.
10. Chang, S.,Mao, S.T.,Hu, S.J.,Lin, W.C.,Cheng, C.L.(2000).Studies of detrusorsphincter synergia and dyssynergia during micturition in rats via fractional Brownian motions.IEEE Trans. Biomed. Eng.,47,1066-1073.
11. Chang, S.,Mao, S.T.,Kuo, T.P.,Hu, S.J.,Lin, W.C.,Cheng, C.L.(1999).Fractal geometry in urodynamics of lower urinary tract.Chinese J. Physiol.,41,25-31.
12. De Groat, W.C.,Downie, J.W.,Levin, R.M.,Long Lin, A.T.,Morrison, J.F.B.,Nishizawa, O.,Steers, W.D.,Thor, K.D.,Abrams, P. (edited),Khoury, S. (edited),Wein, A. (edited)(1999).Incontinence.Plymouth, UK:Plymouth Distributors Ltd.
13. Embrechts, P.,Maejima, M.(2002).Selfsimilar Processes.Princeton:Princeton University Press.
14. Feder, J.(1988).Fractals.New York:Plenum Press.
15. Gaskell, W.H.(1916).The Involuntary Nervous System.London, Longmans:Green and Co.
16. Hao, B.L.,Lee, H.C.,Zhang, S.Y.(2000).Fractals related to long DNA sequences and complete genomes.Chaos, Solitons & Fractals,11(6),825-836.
17. Karanikas, C.(2000).The Hausdorff dimension of very weak self-similar fractals described by the Haar wavelet system.Chaos, Solitons & Fractals,11(1-3),275-280.
18. Kolmogorov, A.N.(1940).Wienersche Spiralen und einige andere interessante Kurven im Hilbertschen Raum.C.R. (Doklady) Acad. Sci. USSR,16,115-118.
19. Kruse, M.N.,Belton, A.L.,de Groat, W.C.(1993).Changes in bladder and external urethral sphincter function after spinal cord injury in the rat.Am. J. Physiol.,264,1157-1163.
20. Langley, J.N.(1921).The Autonomic Nervous System.England, Cambridge:Heftier & Sons.
21. Langworhty, O.R.,Kolb, L.C.,Lewis, L.G.(1940).Physiology of Micturition.Baltimore:The Williams & Wilkins Company.
22. Liu, S.C.,Chang, S.(1997).Dimension estimation of discrete-time fractional Brownian motion with applications to image texture classification.IEEE Trans. Image Processing,6,1176-1184.
23. Mandelbrot, B.B.(1982).The Fractal Geometry of Nature.San Francisco:Freeman.
24. Nottale, L.(2005).On the transition from the classical to the quantum regime in fractal space-time theory.Chaos, Solitons & Fractals,25(4),797-803.
25. Paley, R.E.A.C.,Wiener, N.(1934).Fourier Transforms in the Complex Domain.R. I.:American Mathematical Society Providence.
26. Sheehan, D.(1936).Discovery of the autonomic nervous system.Arch. Neurol. Psychiat.,35,1081-1115.
27. Shefchyk, S.J.(2001).Sacral spinal interneurones and the control of urinary bladder and urethral striated sphincter muscle function.J. Physiol.,533,57-63.
28. Standring, S.(2005).Gray's Anatomy.New York:Churchill Livingstone.
29. Voss, R.F.,Peitgen, H.O. (edited),Saupe, D. (edited)(1988).The Science of Fractal Images.New York:Springer-Verlag.
30. Yaglom, A.M.,English Dover (ed.)(1973).An Introduction to the Theory of Stationary Random Functions.New York:Dover.

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