题名

Effects of Arginine Supplementation on Post-Exercise Metabolic Responses

DOI

10.4077/CJP.2009.AMH037

作者

Pu-Hsi Tsai;Tswen-Kei Tang;Chi-Long Juang;Kenny Wen-Chyuan Chen;Chun-An Chi;Mei-Chich Hsu

关键词

arginine ; exercise recovery ; metabolic response

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

52卷3期(2009 / 06 / 01)

页次

136 - 142

内容语文

英文

英文摘要

This study investigated the effects of arginine supplementation on acute metabolic responses during recovery after a single bout of endurance exercise in trained athletes. Twelve healthy male judo athletes were randomly divided into two groups and performed a single bout of exercise at a speed estimated to correspond to 75% VO2max for 60 min, and then took either a placebo or arginine at 0.1g/kg-wt. Blood samples of each athlete were collected before exercise, and 0, 15, 30, 45, 60, 90, 120 min after exercise, respectively. The experiment was repeated two weeks later, but treatments were exchanged for the two groups. The concentrations of glucose, insulin, free fatty acid (FFA), glycerol, lactate, ammonia, creatine kinase, and NO(subscript x) (NO2(superscript -)+(NO3(superscript -) in blood were examined. No differences in the levels of glycerol, lactate, ammonia, creatine kinase, or NO(subscript x) between the two groups were observed at any of the time points. However, the concentration of glucose was significantly higher in the arginine group as compared to that in the placebo group at the 15-min recovery point. The insulin concentration was also higher in the arginine group as compared to that in the placebo group at the 30-min recovery point. Furthermore, the free fatty acid levels at the 30, and 45-min recovery points were significantly lower in the arginine group compared to those in the placebo group. The results indicated that arginine supplementation during the exercise recovery period could increase glucose and insulin concentrations, and decrease FFA availability in the blood.

主题分类 醫藥衛生 > 基礎醫學
参考文献
  1. Akiyama, K.,Suzuki, H.,Grant, P.,Bing, R.J.(1997).Oxidation products of nitric oxide, NO2 and NO3, in plasma after experimental myocardial infarction.J. Mol. Cell. Cardiol.,29,1-9.
  2. Apostol, A.T.,Tayek, J.A.(2003).A decrease in glucose production is associated with an increase in plasma citrulline response to oral arginine in normal volunteers.Metabolism,52,1512-1516.
  3. Berneis, K.,Ninnis, R.,Haussinger, D.,Keller, U.(1999).Effects of hyper-and hypoosmolality on whole body protein and glucose kinetics in humans.Am. J. Physiol. (Endocrinol. Metab.),276,188-195.
  4. Blachier, F.,Mourtada, A.,Sener, A.,Malaisse, W.J.(1989).Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets.Endocrinology,124,134-141.
  5. Borg, G.A.(1973).Perceived exertion: a note on "history" and methods.Med. Sci. Sports Exerc.,5,90-93.
  6. Coppack, S.W.,Jensen, M.D.,Miles, J.M.(1994).In vivo regulation of lipolysis in humans.J. Lipid Res.,35,177-193.
  7. Dela, F.,Mikines, K.J.,Tronier, B.,Galbo, H.(1990).Diminished arginine-stimulated insulin secretion in trained men.J. Appl. Physiol.,69,261-267.
  8. Efendic, S.,Caresi, E.,Luft, R.(1974).Quantitative study on the potential effect of arginine on glucose-induced insulin response in healthy, prediabetic, and diabetic subjects.Diabetes,23,161-171.
  9. Floyd, J.C.,Fajans, S.S.,Conn, J.W.,Knopf, R.F.,Rull, J.(1966).Stimulation of insulin secretion by amino acids.J. Clin. Invest.,45,1487-1502.
  10. Fluckey, J.D.,Kraemer, W.J.,Farrell, P.A.(1995).Pancreatic islet insulin secretion is increased after resistance exercise in rats.J. Appl. Physiol.,79,1100-1105.
  11. Flynn, N.E.,Meininger, C.J.,Haynes, T.E.,Wu, G.(2002).The metabolic basis of arginine nutrition and pharmacotherapy.Biomed. Pharmacother.,56,427-438.
  12. Gannon, M.C.,Nuttall, J.A.,Nuttall, F.Q.(2002).Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal.Am. J. Clin. Nutr.,76,1016-1022.
  13. Gleeson, M.,Maughan, R.J.,Greenhaff, P.L.(1986).Comparison of the effects of pre-exercise feeding of glucose, glycerol and placebo on endurance and fuel homeostasis in man.Eur. J. Appl. Physiol. Occup. Physiol.,55,645-653.
  14. Green, G.L.,Wagner, D.A.,Glogowski, J.,Skipper, P.L.,Wishnok, J.S.,Tannenbaum, S.(1982).Analysis of nitrate, nitrite and 15N-nitrate in biological fluids.Anal. Biochem.,126,131-138.
  15. Gropper, S.S.,Smith, J.L.,Groff, J.L.(2004).Advanced nutrition and human metabolism.Belmont, CA:Thomson Learing.
  16. Henningsson, R.,Lundquist, I.(1998).Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production.Am. J. Physiol.,275,500-506.
  17. Hermans, M.P.,Schmeer, W.,Henquin, J.C.(1987).The permissive effect of glucose, tolbutamide and high K1 on arginine stimulation of insulin release in isolated mouse islets.Diabetologia,30,659-665.
  18. Ignarro, L.J.,Fukuto, J.M.,Griscavage, J.M.,Rogers, N.E.,Byrns, R.E.(1993).Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.Proc. Natl. Acad. Sci. USA,90,8103-8107.
  19. King, D.S.,Staten, M.A.,Kohrt, W.M.,Dalsky, G.P.,Elahi, D.,Holloszy, J.O.(1990).Insulin secretory capacity in endurance-trained and untrained young men.Am. J. Physiol.,259,155-161.
  20. Kingwell, B.A.,Sherrard, B.,Jennings, G.L.,Dart, A.M.(1997).Four weeks of cycle training increases basal production of nitric oxide from the forearm.Am. J. Physiol.,272,1070-1077.
  21. Larsson, H.,Ahren, B.(1998).Glucose-dependent arginine stimulation test for characterization of islet function: studies on reproducibility and priming effect of arginine.Diabetologia,41,772-777.
  22. Levin, S.R.,Grodsky, G.M.,Hagura, R.,Smith, D.F.,Forsham, P.H.(1972).Relationships between arginine and glucose in the induction of insulin secretion from the isolated perfused rat pancreas.Endocrinology,90,624-631.
  23. Marion-Latard, F.,Crampes, F.,Zakaroff-Girard, A.,De Glisezinski, I.,Harant, I.,Stich, V.,Thalamas, C.,Riviere, D.,Lafontan, M.,Berlan, M.(2003).Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained healthy obese men.Horm. Metab. Res.,35,97-103.
  24. Palmer, J.P.,Walter, R.M.,Ensinck, J.W.(1975).Arginine-stimulated acute phase of insulin and glucagon secretion. I. In normal man.Diabetes,24,735-740.
  25. Panagiotidis, G.,Alm, P.,Lundquist, I.(1992).Inhibition of islet nitric oxide synthase increases arginine-induced insulin release.Eur. J. Pharmacol.,229,277-278.
  26. Paolisso, G.,Tagliamonte, M.R.,Marfella, R.,Verrazzo, G.,D''Onofrio, F.,Giugliano, D.(1997).L-arginine but not D-arginine stimulates insulin-mediated glucose uptake.Metabolism,46,1068-1073.
  27. Robinson, T.M.,Sewell, D.A.,Greenhaff, P.L.(2003).L-arginine ingestion after rest and exercise: effects on glucose disposal.Med. Sci. Sports Exerc.,35,1309-1315.
  28. Salehi, A.,Carlberg, M.,Henningson, R.,Lundquist, I.(1996).Islet constitutive nitric oxide synthase: biochemical determination and regulatory function.Am. J. Physiol.,270,1634-1641.
  29. Schmidt, H.H.,Warner, T.D.,Ishii, K.,Sheng, H.,Murad, F.(1992).Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.Science,255,721-723.
  30. Trabelsi, F.,Lavoie, J.M.(1996).Arginine-induced pancreatic hormone secretion during exercise in rats.J. Appl. Physiol.,81,2528-2533.
  31. van Haeften, T.W.,Voetberg, G.A.,Gerich, J.E.,van der Veen, E.A.(1989).Doseresponse characteristics for arginine-stimulated insulin secretion in man and influence of hyperglycemia.J. Clin. Endocrinol. Metab.,69,1059-1064.
  32. Wolfe, R.R.,Klein, S.,Carraro, F.,Weber, J.M.(1990).Role of triglyceridefatty acid cycle in controlling fat metabolism in humans during and after exercise.Am. J. Physiol.,258,382-389.
  33. Yaspelkis, B.B.,Ivy, J.L.(1999).The effect of a carbohydrate-arginine supplement on postexercise carbohydrate metabolism.Int. J. Sport Nutr.,9,241-250.
被引用次数
  1. Su, Borcherng,Hsu, Mei-Chich,Hsu, Cheng-Chen,Chung, Chia-Jung,Chien, Kuei-Yu,Chan, Kuei-Hui(2011).Effects of BCAA, Arginine and Carbohydrate Combined Drink on Post-Exercise Biochemical Response and Psychological Condition.中國生理學雜誌,54(2),1-8.