题名

Male Sexual Behavior and Brain Catecholamine Levels in Middle-Aged Rats

DOI

10.4077/CJP.2009.AMK020

作者

Houng-Wei Tsai；Joyce C. Chen；Kuei-Ying Yeh；Mei-Yun Tai；Yuan-Feen Tsai

关键词

copulatory behavior ； catecholamine ； medial preoptic area ； nucleus accumbens ； the bed nucleus of stria terminalis ； middle-aged rats ； aging

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

52卷4期（2009 / 08 / 01）

页次

215 - 222

内容语文

英文
英文摘要

During aging, increased qualitative variations in copulatory behavior are observed in male rats. At the age of 18-19 months, only a small proportion of male rats (16%) still display the complete mating behavior, including mounts, intromissions, and ejaculations, but the rest of these middle-aged animals (84%) fail to exhibit one, two or all of the three behavioral components. With distinct behavioral phenotypes, the middle-aged male rats provide us a useful animal model to investigate the neuroendocrine mechanisms responsible for the age-related reduction in sexual behavior. We have previously elucidated the correlation between the loss of specific copulatory behavioral components and tissue levels of catecholamines in the medial preoptic area (MPOA), nucleus accumbens (NAc) and the bed nucleus of stria terminalis (BNST) of middle-aged male rats. Thus, our findings not only demonstrate that levels of dopamine and norepinephrine in the MPOA, NAc and BNST are critical for eliciting copulatory behavior, but also suggest that these two neurotransmitters play distinct roles in different brain regions to control specific behavioral components in male rats.
主题分类 醫藥衛生 > 基礎醫學
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