题名

Effects of Amphetamine and Cocaine on Behavior Maintained by Differential Reinforcement of Low-Rate-Response (DRL) Schedule

DOI

10.4077/CJP.2009.AMK021

作者

Ruey-Ming Liao

关键词

operant conditioned behavior ； psychopharmacology ； timing ； behavioral inhibition ； rat

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

52卷4期（2009 / 08 / 01）

页次

250 - 263

内容语文

英文
英文摘要

Although a number of previous review articles cover the effects of psychostimulant drugs on the operant or schedule-controlled behavior, none of those had focused on the effects of amphetamine and cocaine on operant behavior exclusively maintained by differential reinforcement of low-rate response (DRL). This review (a) summarizes research on the psychopharmacology of amphetamines and cocaine that has been conducted using DRL behavior, (b) discusses the potential neural substrates underlying the aforementioned drug-induced behavioral alterations on the basis of the data from lesion studies, and (c) highlights two major behavioral components, behavioral inhibition and temporal control of DRL responding, that are altered by amphetamines and cocaine. Amphetamines and cocaine affect the development and/or performance of DRL behavior in dose related ways that can be differentiated on the basis of the specific types of behavioral alterations. In general, with the moderate but effective doses, these drugs significantly increase the total number of responses and decrease the number of reinforced responses. Although the burst responses with very short inter-response times (IRT's) are more likely increased by these drugs, this aspect of the drugs' effects were found to vary across studies that used different experimental procedures of shaping up or training the subject to perform DRL behavior. Both amphetamine and cocaine produce a leftward shift on the IRT frequency distribution curve compared to vehicle treatment. The effects of amphetamines and cocaine on DRL behavior as reviewed here further highlight the need for additional research to probe neurobehavioral mechanisms that may underlie DRL behavior as manifested by both burst responding and timing the emission of the operant response.
主题分类 醫藥衛生 > 基礎醫學
参考文献
  1. Cheng, R.-K.,Liao, R.-M.(2007).Dopamine receptor antagonists reverse amphetamine-induced behavioral alteration on a differential reinforcement for low-rate (DRL) operant task in the rat.Chinese J. Physiol.,50,77-88.
    連結：
  2. Anger, D.(1956).The dependence of interresponse times upon the relative reinforcement of different interreposnse times.J. Exp. Psychol.,52,145-161.
  3. Baisden, R.H.,Woodruff, M.L.(1980).Behavioral effects of hippocampal lesions in rats with prior intraseptal injection of 6-hydroxydopamine.Physiol. Psychol.,8,33-39.
  4. Balcells-Olivero, M.,Richards, J.B.,Seiden, L.S.(1997).Sensitization to amphetamine on the differential-reinforcement-of-low-rate 72-s schedule.Psychopharmacology,133,207-213.
  5. Bannerman, D.M.,Yee, B.K.,Good, M.A.,Heupel, M.J.,Iverasen, S.D.,Rawlins, J.N.P.(1999).Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions.Behav. Neursci.,113,1170-1188.
  6. Bardo, M.T.,Caim, M.E.,Bylica, K.E.(2006).Effect of amphetamine on response inhibition in rats showing high or low response to novelty.Pharmacol. Biochem. Behav.,85,98-104.
  7. Barrett, J.E.,Sanger, D.J.(1991).Behavioral pharmacology in the era of neuroscience.J. Exp. Anal. Behav.,56,167-169.
  8. Bizot, J.-C.(1998).Effects of various drugs including organophosphorus compounds (OPC) and therapeutic compounds against OPC on DRL responding.Pharmacol. Biochem. Behav.,59,1069-1080.
  9. Boulton, A.A.,Baker, G.B.,Greenshaw, A.J.(1989).Neuromethods (vol. 13): Psychopharmacology.Clifton, New Jersey:Humana Press.
  10. Britton, K.T.,Koob, G.F.(1989).Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement.Pharmacol. Biochem. Behav.,32,967-970.
  11. Brookes, S.,Rawlins, J.N.P.,Gray, J.A.,Feldon, J.(1983).DRL performance in rats with medial or lateral septal lesions.Physiol. Psychol.,11,178-184.
  12. Canon, J.G.,Lippa, A.S.(1977).Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs.Pharmacol. Biochem. Behav.,6,591-593.
  13. Chang, Y.-H.,Liao, R.-M.,Lan, C.-H.,Sheng, Y.-L.(2000).Tail-Pinch alters operant behavior in the rat: effects of d-amphetamine.Chinese J. Physiol.,43,105-111.
  14. Cheng, R.-K.(2002).Taipei,National Cheng-Chi University.
  15. Cheng, R.-K,MacDonald, C.J.,Meck, W.H.(2006).Differential effects of cocaine and ketamine on timing estimation: implications of neurobiological models of interval timing.Pharmacol. Biochem. Behav.,85,114-122.
  16. Clark, C.V.H.,Isaacson, R.L.(1965).Effects of bilateral hippocampal ablation on DRL performance.J. Comp. Physiol. Psychol.,59,137-140.
  17. Cunha-Oliveira, T.,Rego, A.C.,Oliveira, C.R.(2008).Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs.Brain Res. Rev.,58,192-208.
  18. DeFrance, J.F.(1976).Advances in Behavioral Biology (vol. 20): The Septal Nuclei.New York:Plenum Press.
  19. Dews, P.B.(1958).Studies on behavior. IV. Stimulant actions of methamphetamine.J. Pharmacol. Exp. Ther.,122,137-147.
  20. Dews, P.B.,Morse, W.H.(1961).Behavioral pharmacology.Annu. Rev. Pharmacol.,1,145-174.
  21. Dews, P.B.,Wenger, G.R.,Thompson, T. (edited),Dews, P.B.(1977).Advance in Behavioral Pharmacology.New York:Academic Press.
  22. Doughty, A.H.,Richards, J.B.(2002).Effects of reinforcer magnitude on responding under differential reinforcement of low rate schedules of rats and pigeons.J. Exp. Anal. Behav.,78,17-30.
  23. Dworkin, S.I.,Smith, J.E.,Boulton, A.A. (edited),Baker, G.B.,Greenshaw, A.J.(1989).Neuromethods: Psychopharmacology.Clifton, New Jersey:Humana Press.
  24. Evans, J.A.C.,Thornton, E.W.(1984).Impaired acquisition of DRL operant responding following lesion of the habenular nucleus.Physiol. Psychol.,12,220-226.
  25. Evenden, J.L.(1999).Varieties of impulsivity.Psychopharmacology,146,348-361.
  26. Ferguson, S.A.,Cada, A.M.,Gray, E.P.,Paule, M.G.(2001).No alterations in the performance of two interval timing operant tasks after α-difluoromethylornithine (DFMO)-induced cerebellar stunting.Behav. Brain Res.,126,135-146.
  27. Ferster, C.B.,Skinner, B.F.(1957).Schedule of Reinforcement.New York:Appleton-Century-Crofts.
  28. Finger, S.,Altemus, K. L.,Green, L.,Wolf, C.,Miller, J.,Almli, C.R.(1987).Effects of medial frontal cortex lesions on DRL performance in rats.Physiol. Behav.,41,381-389.
  29. Fletcher, P.J.(1995).Effects of combined or separate 5,7-dihydroxytryptamine lesions of the dorsal and medial raphe nuclei on responding maintained by a DRL 20s schedule of food reinforcement.Brain Res.,675,45-54.
  30. Fletcher, P.J.(1994).Effects of 8-OH-DPAT, 5-CT and muscimol on behavior maintained by a DRL20 schedule of reinforcement, following microinjection into the dorsal or median raphe nuclei.Behav. Pharmacol.,5,326-336.
  31. Fowler, S.C.,Pinkston, J.,Vorontsova, E.(2009).Timing and space usage are disrupted by amphetamine in rats maintained on DRL 24-s and DRL 72-s schedules of reinforcement.Psychopharmacology,204,216-225.
  32. Grilly, D.M.,Loveland, A.(2001).What is a "low dose" of damphetamine for inducing behavioral effects in laboratory rats?.Psychopharmacology,153,155-169.
  33. Harvey, J.A.(1987).Behavioral pharmacology of central nervous system stimulants.Neuropharmacology,26,887-892.
  34. Higgins, G.A.,Ballard, T.M.,Huwyler, J.,Kemp, J.A.,Gill, R.(2003).Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behavior: evidence for an involvement of NR2B NMDA receptor in response inhibition.Neuropharmacology,44,324-341.
  35. Hikosaka, O.,Sesack, S.R.,Lecourtier, L.,Shepard, P.(2008).Habenula: crossroad between the basal ganglia and limbic system.J. Neurosci.,28,11825-11829.
  36. Ivry, R.,Schmahmann, J. (edited)(1997).The Cerebellum and Cognition: International Review of Neurobiology.San Diego:Academic Press.
  37. Jentsch, J.D.,Taylor, J.R.(1999).Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.Psychopharmacology,146,373-390.
  38. Johanson, C.-E.,Fischman, M.W.(1989).The pharmacology of cocaine related to its abuse.J. Pharmacol. Exp. Ther.,41,3-52.
  39. Johnson, C.T.,Olton, D.S.,Gage III, F.H.,Jenko, P.G.(1977).Damage to hippocampal connections: effects on DRL and spontaneous alternation.J. Comp. Physiol. Psychol.,91,508-522.
  40. Kalivas, P.W.(2004).Glutamate systems in cocaine addiction.Curr. Opin. Pharmacol.,4,23-29.
  41. Kalivas, P.W.,Sorg, B.A.,Hooks, M.S.(1993).The pharmacology and neural circuitry of sensitization to psychostimulants.Behav. Pharmacol.,4,315-334.
  42. Kramer, T.J.,Rilling, M.(1970).Differential reinforcement of low rates: a selective critique.Psychol. Bull.,74,225-254.
  43. Kubos, K.L.,Brady, J.V.,Moran, T.H.,Smith, C.H.,Robinson, R.G.(1985).Asymmetrical effects of unilateral cortical lesions and amphetamine on DRL-20: a time-loss analysis.Pharmacol. Biochem. Behav.,22,1001-1006.
  44. Levine, T.E.,McGuire, P.S.,Heffner, T.G.,Seiden, L.S.(1980).DRL performance in 6-hydroxydopamine-treated rats.Pharmacol. Biochem. Behav.,12,287-291.
  45. Liao, R.-M.,Chang, Y.-H.(2001).Different effects of 5-HT receptor agonists on rat's operant responding under DRL 10-s and DRL 30-s schedules.Proc. Natl. Sci. Council R.O.C. (part B): Life Sci.,25,223-232.
  46. Liao, R.-M.,Cheng, R.-K.(2005).Acute effects of d-amphetamine on the DRL behavior in the rat: comparison with selective dopamine receptor antagonists.Chinese J. Physiol.,48,41-50.
  47. Lucki I.,DeLong, R.E.(1983).Control rate of response or reinforcement and amphetamine's effect on behavior.J. Exp. Anal. Behav.,40,123-132.
  48. Ludvig, E.A.,Conover, K.,Shizgal, P.(2007).The effects of reinforcer magnitude on timing in rats.J. Exp. Anal. Behav.,87,201-218.
  49. Ma, F.,Falk, J.L.,Lau, C.E.(1999).Cocaine pharmacodynamics after intravenous and oral administration in rats: related pharmacokinetics.Psychopharmacology,144,323-332.
  50. McClure, G.Y.H.,McMillan, D.E.(1997).Effects of drugs on response duration differentiation. VI: differential effects under differential reinforcement of low rates of responding schedules.J. Pharmacol. Exp. Ther.,281,1368-1380.
  51. McKetin, R.,Kozol, N.,Douglas, J.,Ali, R.,Vicknasingam, B.,Lund, J.,Li, J.-H.(2008).The rise of methamphetamine in southeast and east Asia.Drug Alcoh. Rev.,27,220-228.
  52. McKim, W.A.(2007).Drugs and Behavior: an Introduction to Behavioral Pharmacology.Upper Saddle River, New Jersey:Pearson Prentice Hall.
  53. Meck, W.H.(1996).Neuropharmacology of timing and time perception.Cogn. Brain Res.,3,227-242.
  54. Meck, W.H.(2006).Neuroanatomical localization of an internal clock: a functional link between mesolimbic, nigrostriatal, and mesocorticaql dopaminergic systems.Brain Res.,1109,93-107.
  55. Meck, W.H.,Penny, T.B.,Pouthas, V.(2008).Cortico-striatal representation of time in animas and humans.Curr. Opin. Neurobiol.,18,145-152.
  56. Michaelis, R.C.,Holloway, F.A.,Bird, D.C.,Huerta, P.L.(1987).Interactions between stimulants: effects on DRL performance and lethality in rats.Pharmacol. Biochem. Behav.,27,299-306.
  57. Neill, D.B.(1976).Frontal-striatal control of behavioral inhibition in the rat.Brain Res.,105,89-103.
  58. Nestler, E.J.(1997).Molecular mechanisms of opiate and cocaine addiction.Curr. Opin. Neurobiol.,7,713-719.
  59. Nestler, E.J.(2004).Historical review: molecular and cellular mechanisms of opiate and cocaine addiction.Trends Pharmacol. Sci.,25,210-218.
  60. O''Donnell, J.M.,Marek, G.J.,Seiden, L.S.(2005).Antidepressant effects assessed using behavior maintained under a differentialreinforcement-of-low-rate (DRL) operant schedule.Neurosci. Biobehav. Rev.,29,785-798.
  61. Olmstead, M.C.(2006).Animal models of drug addiction: where do we go from here?.Quart. J. Exp. Psychol.,59,625-653.
  62. Paule, M.G.,Meck, W.H.,McMillan. D.E.,McClure, G.Y.H.,Bateson, M.,Popke, E.J.,Chelonis. J.J.,Hinton, S.C.(1999).The use of timing behaviors in animals and human to detect drug and/or toxicant effects.Neurotoxicol. Teratol.,21,491-502.
  63. Peterson, J.D.,Wolf, M.E.,White, F.J.(2003).Impaired DRL 30 performance during amphetamine withdrawal.Behav. Brain Res.,143,101-108.
  64. Piazza, P.V.,Le Moal, M.(1998).The role of stress in drug selfadministration.Trends Pharmacol. Sci.,19,67-74.
  65. Pothuizen, H.H.,Jongen-Relo, A.,Feldon, J.,Yee, B.K.(2005).Double dissociation of the effects of selective nucleus accumbens core and shell lesions on impulsive-choice behavior and salience learning in rats.Eur. J. Neurosci.,22,2605-2616.
  66. Reading, P.J.,Dunnett, S.B.(1995).Embryonic striatal grafts reverse the disinhibitory effects of ibotenic acid lesions of the ventral striatum.Exp. Brain Res.,105,76-86.
  67. Richards, J.B.,Sabol, K.E.,Seiden, L.E.(1993).DRL interressponsetime distributions: quantification by peak deviation analysis.J. Exp. Anal. Behav.,60,361-368.
  68. Robinson, T.E.,Becker, J.B.(1986).Enduring changes in brain and behavior produced chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis.Brain Res. Rev.,396,157-198.
  69. Sabol, K.E.,Richards, J.B.,Layton, K.,Seiden, L.E.(1995).Amphetamine analogs have differential effects on DRL 36-s schedule performance.Psychopharmacology,121,57-65.
  70. Sahgal, A.(1993).Behavioral Neuroscience.New York:Oxford University Press.
  71. Sanger, D.J.(1992).NMDA antagonists disrupt timing behavior in rats.Behav. Pharmacol.,3,593-600.
  72. Sanger, D.J.(1988).The α2-adrenoceptor antagonists idazoxan and yohimbine increase rat of DRL responding in rats.Psychopharmacology,95,413-417.
  73. Sanger, D.J.,Blackman, D.E.(1975).The effects of tranquillizing drugs on timing behavior in rats.Psychopharmacologia,44,153-156.
  74. Sanger, D.J.,Blackman, D.E.,Boulton, A.A. (edited),Baker, G.B.,Greenshaw, A.J.(1989).Neuromethods: Psychopharmacology.Clifton, New Jersey:Humana Press.
  75. Sanger, D.J.,Jackson, A.(1989).Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.J. Pharmacol. Exp. Ther.,248,1215-1221.
  76. Sanger, D.J.,Key, M.,Blackman, D.E.(1974).Differential effects of chlordiazepoxide and d-amphetamine on responding maintained by a DRL schedule of reinforcement.Psychopharmacologia,38,159-171.
  77. Seiden, L.S.,Sabol, K.E.,Ricaurte, G.A.(1993).Amphetamine: effects on catecholamine systems and behavior.Annu. Rev. Pharmacol. Toxicol.,33,639-677.
  78. Shaham, Y.,Erb, S.,Steward, J.(2000).Stress-induced relapse to heroin and cocaine seeking in rats: a review.Brain Res. Rev.,33,13-33.
  79. Sidman, M.(1955).Technique for assessing the effects of drugs on timing behavior.Science,122,925.
  80. Sinden, J.D.,Rawlins, J.N.P.,Gray, J.A.,Jarrard, L.E.(1986).Selective cytotoxic lesions of the hippocampal formation and DRL performance in rats.Behav. Neurosci.,100,320-329.
  81. Skinner, B.F.(1938).The Behavior of Organisms.New York:Appleton Century Crofts.
  82. Sokolowski, J.D.,Salamone, J.D.(1994).Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat.Brain Res.,642,20-28.
  83. Stephens, D.N.,Cole, B.J.(1996).AMPA antagonists differ from NMDA antagonists in their effects on operant DRL and delayed matching to position tasks.Psychopharmacology,126,249-259.
  84. Stoffel, E.C.,Cunningham, K.A.(2008).The relationship between the locomotor response to a novel environment and behavioral disinhibition in ratys.Drug Alco. Depend.,92,69-78.
  85. Sukhotina, I.A.,Dravolina, O.A.,Novitskaya, Y.,Zvartau, E.E.,Danysz, W.,Bespalov, A.Y.(2008).Effects of mGlu1 receptor blockade on working, time estimation, and impulsivity in rats.Psychopharmacology,196,211-220.
  86. Sulzer, D.,Sonders, M.S.,Poulsen, N.W.,Galli, A.(2005).Mechanisms of neurotransmitter release by amphetamine: a review.Prog. Neurobiol.,75,406-433.
  87. Sutherland, R.J.(1982).The dorsal diencephalic conduction system: a review of the anatomy and functions of the habenular complex.Neurosci. Biobehav. Rev.,6,1-13.
  88. Svarnik, C.E.,Alexandrov, Y.I.,Gavrilov, V.V.,Grinchenko, Y.V.,Anokhin, K.V.(2005).Fos expression and task-related neuronal activity in rat cerebral cortex after instrumental learning.Neuroscience,136,33-42.
  89. Thornton, E.W.,Bradbury, G.E.,Wickens, A.P.,Mottram, D.R.,McClelland, R.(1990).Intra-habenular injection of 6-hydroxydopamine produces impaired acquisition of DRL operant behavior.Behav. Neural Biol.,53,291-297.
  90. Tonkiss, J.,Moriss, R.G.M.,Rawlins, J.N.P.(1988).Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat.Exp. Brain Res.,73,181-188.
  91. Van Haaren, F.(1993).Techniques in the Behavioral and Neural Sciences (vol. 10): Methods in Behavioral Pharmacology.Amsterdam:Elsevier.
  92. Van Hest, A.,Drimmelen, M.,Olivier, B.(1992).Flesinoxan shows antidepressant activity in a DRL 72-s screen.Psychopharmacology,107,474-479.
  93. Wang, Q.,Simpao, A.,Sun, L.,Falk, J.L.,Lau, C.E.(2001).Contribution of the active metabolite, norcocaine, to cocaine's effects after intravenous and oral administration in rats: pharmacodynamics.Psychopharmacology,153,341-352.
  94. Welzl, H.,Berz., S.,Battig, K.(1991).The effects of the noncompetitive NMDA receptor antagonist MK801 on DRL performance.Psychobiology,19,211-216.
  95. Wenger, G.R.,Wright, D.W.(1990).Behavioral effects of cocaine and its interaction with d-amphetamine and morphine in rats.Pharmacol. Biochem. Behav.,35,595-600.
  96. Wiley, J.L.,Compton, A.D.,Golden, K.M.(2000).Separation of drug effects on timing and behavioral inhibition by increased stimulus control.Exp. Clin. Psychopharmacol.,8,451-461.
  97. Willner, P.(1991).Behavioral Models in Psychopharmacology: Theoretical, Industrial, and Clinical perspectives.Cambridge:Cambridge University Press.
  98. Woolverton, W.,Johnson, K.M.(1992).Neurobiology of cocaine abuse.Trends Pharmacol. Sci.,13,193-200.
  99. Woolverton, W.L.,Kandel, D.,Schuster, C.R.(1978).Effects of repeated administration of cocaine on schedule-controlled behavior of rats.Pharmacol. Biochem. Behav.,9,327-337.
  100. Yano, M.,Steiner, H.(2007).Methylphenidate and cocaine: the same effects on gene regulation?.Trends Pharmacol. Sci.,28,588-596.
  101. Young, B.,McNaughton, N.(2000).Common firing patterns of hippocampal cells in a differential reinforcement of low rates of response schedule.J. Neurosci.,20,7043-7051.
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