题名

State-Dependent Amygdala Stimulation-Induced Cardiovascular Effects in Rats

DOI

10.4077/CJP.2009.AMH046

作者

Ruei-Jen Chiou;Chung-Chih Kuo;Keng-Chen Liang;Chen-Tung Yen

关键词

amygdale ; anesthesia ; blood pressure ; heart rate ; electrical stimulation ; ketamine ; pentobarbital ; chloralose ; urethane

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

52卷6期(2009 / 12 / 01)

页次

432 - 440

内容语文

英文

英文摘要

Stimulation of the amygdala is known to produce pressor, depressor, or has no effects. The present study was performed to test whether amygdala cardiovascular effects are influenced by consciousness states and by different types of anesthetics. Adult rats were set up for stimulation amygdala and measurement of blood pressure in a chronic preparation. After recovery, same sites of the amygdala were stimulated electrically for several trials with the rat under conscious or anesthetic states induced by pentobarbital, urethane, ketamine, α-chloralose and urethane plus α-chloralose, respectively. The interval between any two stimulation trials was at least 2 days. The stimulation was an 80-Hz, 0.5-ms, 100-μA square wave pulse train lasting for 15 s. Cardiovascular responsive sites were found in the central, medial, and basolateral nuclei of the amygdala. In stimulating these responsive sites, significantly different cardiovascular effects were induced under a conscious state and an anesthetized state of the animal, yet no significant differences were found among the various anesthetic agents. We conclude, that the cardiovascular influence of the amygdala is state-dependent in the rat.

主题分类 醫藥衛生 > 基礎醫學
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