The Effect of Eight Weeks of Supplementation with Eleutherococcus senticosus on Endurance Capacity and Metabolism in Human

10.4077/CJP.2010.AMK018

Jip Kuo；Kenny Wen-Chyuan Chen；I-Shiung Cheng；Pu-Hsi Tsai；Ying-Jui Lu；Ning-Yuean Lee

ciwujia ； ergogenic aid ； aerobic exercise

The Chinese Journal of Physiology

53卷2期（2010 / 04 / 01）

105 - 111

英文

The aim of this study was to examine the effects of Eleutherococcus senticosus (ES) supplementation on endurance capacity, cardiovascular functions and metabolism of recreationally trained males for 8 weeks. Nine recreationally trained males in college consumed 800 mg/d of ES or starch placebo (P) for 8 weeks according to a double-blind, randomized, placebo controlled and crossover design with a washout period of 4 weeks between the cycling trials. Subjects cycled at 75% VO2 peak until exhaustion. The examined physiological variables included endurance time, maximal heart rate during exhaustion exercise, VO2, rating of perceived exertion and respiratory exchange ratio. The biochemical variables including the plasma free fatty acid (FFA) and glucose were measured at rest, 15 min, 30 min and exhaustion. The major finding of this study was the VO2 peak of the subjects elevated 12% (P＜0.05), endurance time improved 23% (P＜0.05) and the highest heart rate increased 4% (P＜0.05) significantly. The second finding was at 30 min of 75% VO2 peak cycling, the production of plasma FFA was increased and the glucose level was decreased both significantly (P＜0.05) over 8-week ES supplementation. This is the first well-conducted study that shows that 8-week ES supplementation enhances endurance capacity, elevates cardiovascular functions and alters the metabolism for sparing glycogen in recreationally trained males.

1. Applegate, E.(1999).Effective nutritional ergogenic aids.Int. J. Sports Nutr.,9,229-239.
2. Asano, K.T.,Miyashi, T.M.,Matsuzaka, A.,Muramatsu, S.,Kuboyama, M.(1986).Effect of Eleutherococcus senticosus extract on human physical working capacity.Plant Med.,3,175-177.
3. Bahrke, M.S.,Morgan, W.P.(2000).Evaluation of the ergogenic properties of ginseng.Sports Med.,29,113-133.
4. Cheuvront, S.N.,Moffatt, R.J.,Biggerstaff, K.D.,Bearden, S.,McDonough, P.(1999).Effect of ENDUROX on metabolic responses to submaximal exercise.Int. J. Sport Nutr.,9,434-442.
5. Davydov, M.,Krikorian, A.D.(2000).Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look.J. Ethno. Pharmacol.,72,345-393.
6. DowIing, E.A.,Redondo, D.R.,Branch, J.D.,Jones, S.,McNabb, G.,Williams, M.H.(2000).Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance.Med. Sci. Sports Exerc.,28,482-489.
7. Eschbach, L.F.,Webster, M.J.,Boyd, J.C.,McArthur, P.D.,Evetovich, T.K.(2000).The effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance.Int. J. Sport Nutr. Exerc. Metab.,10,444-451.
8. Gleeson, M.,Maughan, R.J.,Greenhaff, P.L.(1986).Comparison of the effects of pre-exercise feeding of glucose, glycerol and placebo on endurance and fuel homeostasis in man.Eur. J. Appl. Physiol. Occup. Physiol.,55,645-653.
9. Goulet, E.D.,Dionne, I.J.(2005).Assessment of the Effects of Eleutherococcus senticosus on endurance performance.Int. J. Sport Nutr. Exerc. Metab.,14,75-83.
10. Hurley, B.F.,Nemeth, P.M.,Martin, W.H.,Hagberg, J.M.,Dalsky, G.P.,Holloszy, J.O.(1986).Muscle triglyceride utilization during exercise: effect of training.J. Appl. Physiol.,60,562-567.
11. Kiens, B.,Essen-Gustavsson, B.,Christensen, N.J.,Saltin, B.(1993).Skeletal muscle substrate utilization during sub-maximal exercise in man: effect of endurance training.J. Physiol.,469,459-478.
12. Lawrence, M.E.,Kirby, D.F.(2002).Nutrition and sports supplements: fact or fiction.J. Clin. Gastroenterol.,35,299-306.
13. Li, X.C.,Barnes, D.L.,Khan, I.A.(2001).A new lignan glycoside from Eleutherococcus senticosus.Planta Med.,67,776-778.
14. Liu, K. Y.,Wu, Y.C.,Liu, I.M.,Yu, W.C.,Cheng, J.T.(2008).Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats.Neurosci. Lett.,28,195-199.
15. Marion-Latard, F.,Crampes, F.,Zakaroff-Girard, A.,De Glisezinski, I.,Harant, I.,Stich, V.,Thalamas, C.,Riviere, D.,Lafontan, M.,Berlan, M.(2003).Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained healthy obese men.Horm. Metab. Res.,35,97-103.
16. Maughan, R.J.,King, D.S.,Lea, T.(2004).J. Sports Sci.,22,95-113.
17. McGuffin, M.,Hobbs, C.,Upton, R.,Goldberg, A.(1997).Botanical safety handbook.Boca Raton, FL:CRC Press.
18. McNaughton, L.,Egan, G.,Caelli, G.(1989).A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness.Int. Clin. Nutr. Rev.,9,32-35.
19. Plowman, S.A.,Dustman, K.,Walicek, H.,Corless, C.,Ehlers, G.(1999).The effects of ENDUROX on the physiological responses to stair-stepping exercise.Res. Q. Exerc. Sport,70,385-388.
20. Szolomicki, J.,Samochowiec, L.,Wojcicki, J.,Drozdzik, M.,Szolomicki, S.(2000).The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man.Phytother. Res.,14,30-35.
21. Wolfe, R.R.,Klein, S.,Carraro, F.,Weber, J.M.(1990).Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise.Am. J. Physiol.,258,382-389.
22. Wu, Y.N.,Wang, X.Q.,Zhao, Y.F.,Wang, J.Z.,Chen, H.J.,Liu, H.Z.(1996).Effect of Ciwujia (Radix acanthopanacis senticosus) preparation on human stamina.J. Hyg. Res.,25,57-61.

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