题名

Significant Association of XPD Asp312Asn Polymorphism with Breast Cancer in Taiwanese Patients

DOI

10.4077/CJP.2010.AMK005

作者

Hwei-Chung Wang；Chiu-Shong Liu；Chung-Hsing Wang；Ru-Yin Tsai；Chia-Wen Tsai；Rou-Fen Wang；Chao-Hsiang Chang；Yueh-Sheng Chen；Chang-Fang Chiu；Da-Tian Bau；Chih-Yang Huang

关键词

XPD ； Asp312Asn ； polymorphism ； breast cancer Taiwanese

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

53卷2期（2010 / 04 / 01）

页次

130 - 135

内容语文

英文
英文摘要

The DNA repair gene XPD, an important caretaker of the overall genome stability, is thought to play a major role in the development of human malignancy. Polymorphic variants of XPD, at Asp312Asn (rs1799793), Lys751Gln (rs13181), and promoter C-114G (rs3810366), were chosen to be studied of their association with breast cancer susceptibility in a central Taiwanese population. In this hospital-based case-control study, the associations of XPD Asp312Asn, Lys751Gln and promoter C-114G polymorphisms with breast cancer risk were investigated. In total, 1232 patients with breast cancer and 1433 healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. We found a significant difference in the frequency of the XPD Asp312Asn genotype, but not the XPD Lys751Gln or promoter C-114G genotypes, between the breast cancer and control groups. Those who had G/A or A/A at XPD Asp312Asn showed a 1.78-fold (95% confidence interval=1.53-2.08) increased risk of breast cancer compared to those with G/G. As for XPD Lys751Gln or promoter C-114G, there was no difference in distribution between the breast cancer and control groups. Our findings suggest that the heterozygous and homozygous A allele of the XPD Asp312Asn may be associated with the development of breast cancer and may be a useful marker for primary prevention and anticancer intervention.
主题分类 醫藥衛生 > 基礎醫學
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被引用次数
  1. Yang, Chuan-Wei,Liu, Chiu-Shong,Lin, Wen-Yuan,Lin, Chih-Hsueh,Lin, Cheng-Chieh,Li, Tsai-Chung,Li, Chia-Ing,Ho, Chien-Yi,Bau, Da-Tian(2012).Influence of Adiponectin Gene Polymorphisms on Adiponectin Serum Level and Insulin Resistance Index in Taiwanese Metabolic Syndrome Patients.中國生理學雜誌,55(6),405-411.
  2. Ying, Tsung-Ho,Wang, Paulus S.,Tsai, Chia-Wen,Shui, Hao-Ai,Shih, Liang-Chun,Pan, Sin-Bao,Huang, Chung-Yu,Hsieh, Yi-Hsien,Ho, Chien-Yi,Chen, Ya-Chien,Chen, Chang-Peng,Chang, Wen-Shin,Bau, Da-Tian(2013).The Joint Effect of hOGG1 Genotype and Smoking Habit on Endometriosis in Taiwan.中國生理學雜誌,56(5),263-268.
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