Glucose Uptake Patterns in Exercised Skeletal Muscles of Elite Male Long-Distance and Short-Distance Runners

10.4077/CJP.2010.AMK016

Suh-Jun Tai；Ren-Shyan Liu；Ya-Chen Kuo；Chi-Yang Hsu；Chi-Hsien Chen

FDG ； PET ； muscle recruitment ； glucose uptake ； exercise

The Chinese Journal of Physiology

53卷2期（2010 / 04 / 01）

91 - 98

英文

The aim of this study was to determine glucose uptake patterns in exercised skeletal muscles of elite male long-distance and short-distance runners. Positron emission tomography (PET) using 18F fluoro-2-deoxyglucose (FDG) was performed to determine the patterns of glucose uptake in lower limbs of short-distance (SD group, n=8) and long-distance (LD group, n=8) male runners after a modified 20 min Bruce treadmill test. Magnetic resonance imaging (MRI) was used to delineate the muscle groups in lower limbs. Muscle groups from hip, knee, and ankle movers were measured. The total FDG uptake and the standard uptake value (SUV) for each muscle group were compared between the 2 groups. For the SD and LD runners, the 2 major muscle groups utilizing glucose during running were knee extensors and ankle plantarflexors, which accounted for 49.3 ±8.1% (25.1 ±4.7% and 24.2 ±6.0%) of overall lower extremity glucose uptake for SD group, and 51.3 ±8.0% (27.2 ±2.7% and 24.0 ±8.1%) for LD group. No difference in muscle glucose uptake was noted for other muscle groups. For SD runners, the SUVs for the muscle groups varied from 0.49 ±0.27 for the ankle plantarflexors, to 0.20 ±0.08 for the hip flexor. For the LD runners, the highest and lowest SUVs were 0.43 ±0.15 for the ankle dorsiflexors and 0.21 ± 0.19 for the hip. For SD and LD groups, no difference in muscle SUV was noted for the muscle groups. However, the SUV ratio between the ankle dorsiflexors and plantarflexors in the LD group was significantly greater than that in the SD group. We thus conclude that the major propelling muscle groups account for ~50% of lower limb glucose utilization during running. Thus, the other muscle groups involving maintenance of balance, limb deceleration, and shock absorption utilize an equal amount. This result provides a new insight into glucose distribution in skeletal muscle, suggesting that propellers and supporters are both energetically important during running. Furthermore, for each unit muscle volume, movers of ankle are more glucose-demanding than those of hip.

1. Bergh, U.,Thorstensson, A.,Sjödin, B.,Hulten, B.,Piehl, K.,Karlsson, J.(1978).Maximal oxygen uptake and muscle fiber types in trained and untrained humans.Med. Sci. Sports,10,151-154.
2. Bottinelli, R.,Reggiani, C.(2000).Human skeletal muscle fibres: molecular and functional diversity.Prog. Biophys. Mol. Biol.,73,195-262.
3. Chin, B.B.,Green, E.D.,Turkington, T.G.,Hawk, T.C.,Coleman, R.E.(2009).Skeletal muscle contraction: analysis with use of velocity distributions from phase-contrast MR imaging.Mol. Imaging Biol.,11,118-122.
4. Drace, J.E.,Pelc, N.J.(1994).Skeletal muscle contraction: analysis with use of velocity distributions from phase-contrast MR imaging.Radiology,193,423-429.
5. Franc, B.,Carlisle, M.R.,Segall, G.(2003).Oral administration of F-18 FDG to evaluate a single pulmonary nodule by positron emission tomography in a patient with poor intravenous access.Clin. Nucl. Med.,28,541-544.
6. Fujimoto, T.,Itoh, M.,Kumano, H.,Tashiro, M.,Ido, T. Wholebody(1996).metabolic map with positron emission tomography of a man after running.Lancet,348,266.
7. Fujimoto, T.,Kemppainen, J.,Kalliokoski, K.K.,Nuutila, P.,Ito, M.,Knuuti, J.(2003).Skeletal muscle glucose uptake response to exercise in trained and untrained men.Med. Sci. Sports Exerc.,35,777-783.
8. Iemitsu, M.,Itoh, M.,Fujimoto, T.,Tashiro, M.,Nagatomi, R.,Ohmori, H.,Ishii, K.(2000).Whole-body energy mapping under physical exercise using positron emission tomography.Med. Sci. Sports Exerc.,32,2067-2070.
9. Irwin, S. (edited),Tecklin, J.S.(1985).Cardiopulmonary Physical Therapy.St. Louis, MO:Mosby.
10. Johnson, M.A.,Polgar, J.,Weightman, D.,Appleton, D.(1973).Data on the distribution of fibre types in thirty-six human muscles. An autopsy study.J. Neurol. Sci.,18,111-126.
11. Lin, P.W.,Liu, R.S.,Liou, T.H.,Pan, L.C.,Chen, C.H.(2007).Correlation between joint [F-18] FDG PET uptake and synovial TNF-alpha concentration: a study with two rabbit models of acute inflammatory arthritis.Appl. Radiat. Isot.,65,1221-1226.
12. Loening, A.M.,Gambhir, S.S.(2003).AMIDE: a free software tool for multimodality medical image analysis.Mol. Imaging,2,131-137.
13. Montgomery, W.H.,3rd, Pink, M.,Perry, J.(1994).Electromyographic analysis of hip and knee musculature during running.Am. J. Sports Med.,22,272-278.
14. Nair, N.,Agrawal, A.,Jaiswar, R.(2007).Substitution of oral (18) FFDG for intravenous (18) F-FDG in PET scanning.J. Nucl. Med. Technol.,35,100-104.
15. Ohnuma, M.,Sugita, T.,Kokubun, S.,Yamaguchi, K.,Rikimaru, H.(2006).Muscle activity during a dash shown by 18F-fluorodeoxyglucose positron emission tomography.J. Orthop. Sci.,11,42-45.
16. Rose, A.J.,Richter, E.A.(2005).Skeletal muscle glucose uptake during exercise: How is it regulated?.Physiology (Bethesda),20,260-270.
17. Tashiro, M.,Fujimoto, T.,Itoh, M.,Kubota, K.,Fujiwara, T.,Miyake, M.,Watanuki, S.,Horikawa, E.,Sasaki, H.,Ido, T.(1999).18F-FDG PET imaging of muscle activity in runners.J. Nucl. Med.,40,70-76.
18. Venables, W.N.,Smith, D.M.(2002).Introduction to R.Bristol, UK:Network Theory.
19. Zar, J.H.(1984).Biostatistical Analysis.Englewood Cliffs, NJ:Prentice-Hall.