Functional Interactions in Hierarchically Organized Neural Networks Studied with Spatiotemporal Firing Patterns and Phase-Coupling Frequencies

10.4077/CJP.2010.AMM039

Stephen Perrig；Javier Iglesias；Vladislav Shaposhnyk；Olga Chibirova；Pierre Dutoit；Jérémie Cabessa；Katerina Espa-Cervena；Laurent Pelletier；François Berger；Alessandro E.P. Villa

apoptosis ； spike timing dependent plasticity ； synaptic pruning ； preferred firing sequence ； insomnia ； EEG

The Chinese Journal of Physiology

53卷6期（2010 / 12 / 01）

382 - 395

英文

A scalable hardware/software hybrid module-called Ubidule-endowed with bio-inspired ontogenetic and epigenetic features is configured to run a neural networks simulation with developmental and evolvable capabilities. We simulated the activity of hierarchically organized spiking neural networks characterized by an initial developmental phase featuring cell death followed by spike timing dependent synaptic plasticity in presence of background noise. An upstream 'sensory' network received a spatiotemporally organized external input and downstream networks were activated only via the upstream network. Precise firing sequences, formed by recurrent patterns of spikes intervals above chance levels, were observed in all recording conditions, thus suggesting the build-up of a connectivity able to sustain temporal information processing. The activity of a Ubinet-a network of Ubidules-is analyzed by means of virtual electrodes that recorded neural signals similar to EEG. The analysis of these signals was compared with a small set of human recordings and revealed common patterns of shift in quadratic phase coupling. The results suggest some interpretations of changes and plasticity of functional interactions between cortical areas driven by external stimuli and by learning/cognitive paradigms.

1. Abeles, M.(1991).Corticonics: Nzural Circuits of the Cerebral Cortex.Cambridge:University Press.
2. Ashikaga, M.,Kikuchi, M.,Hiraguchi, T.,Sakura, M.,Aonuma, H.,Ota, J.(2007).Foraging task of multiple mobile robots in a dynamic environment using adaptive behavior in crickets.J. Robotics Mech.,19,466-473.
3. Bellifemine, F. L.,Caire, G.,Greenwood, D.(2007).Developing Multi-Agent Systems With JADE.Hoboken, N.J.:Wiley.
4. Benoskova, L.,Kasabov, N.(2007).Computational Neurogenetic Modeling.New York, NY, USA:Spriger.
5. Bonnet, M. H.,Arand, D. L.(1997).Hyperarousal and insomnia.Sleep Med. Rev.,1,97-108.
6. Braitenberg, V.,Schuez, A.(1998).Cortex: statistics and geometry of neuronal connectivity.Berlin:Springer.
7. Brillinger, D. R.(1965).An introduction to polyspectra.Ann. Math. Stat.,36,1351-1374.
8. Chechik, G.,Meilijson, I.,Ruppin, E.(1999).Neuronal regulation: A mechanism for synaptic pruning during brain maturation.Neural Comput.,11,2061-2080.
9. Conel, J. L.(1939).The Post Natal Development of the Human Cerebral Cortex.Cambridge, MA:Harvard University Press.
10. Cowan, W. M.(ed.)(1981).The neurotrophic theory and naturally occurring motoneuron death.Oxford University Press.
11. Doya, K.,Uchibe, E.(2005).The cyber rodent project: Exploration of adaptive mechanisms for self-preservation and self-reproduction.Adapt. Behav.,13,149-160.
12. Dumermuth, G.,Huber, P. J.,Kleiner, B.,Gasser, T.(1971).Analysis of the interrelations between frequency bands of the EEG by means of the bispectrum. a preliminary study.Electroencephalogr. Clin. Neurophysiol.,31,137-148.
13. Edinger, J. D.,Means, M. K.(2005).Cognitiveñbehavioral therapy for primary insomnia.Clin. Psychol. Rev.,25,539-558.
14. Elston, G. N.(2002).Cortical heterogeneity: implications for visual processing and polysensory integration.J. Neurocytol.,31,317-335.
15. Fouks, J. D.,Besnard, S.,Signac, L.,Meurice, J. C.,Neau, J. P.,Paquereau, J.(2004).Do robots need to sleep?.Neurophysiologie Clinique,34,59-70.
16. Freedman, R.(1986).EEG power speactra in sleep-onset insomnia.Electroencephalograph Clin. Neurophysiol.,63,408-413.
17. Gaillard, J. M.(1978).Chronic primary insomnia: possible physio-pathological involvement of slow wave deficiency.Sleep,1,133-147.
18. Hill, S.,Villa, A. E.(1997).Dynamic transitions in global network activity influenced by the balance of excitation and inhibtion.Network-Comp. Neural.,8,165-184.
19. Hubel, D. H.,Wiesel, T. N.,LeVay, S.(1977).Plasticity of ocular dominance columns in monkey striate cortex.Philos. Trans. R. Soc. Lond. B. Biol. Sci.,278,377-409.
20. Huttenlocher, P. R.(1979).Synaptic density in human frontal cortex-Developmental changes and effects of aging.Brain Res.,163,195-205.
21. Iglesias, J.,Chibirova, O.,Villa, A.(2007).Nonlinear dynamics emerging in large scale neural networks with ontogenetic and epigenetic processes.Lect. Notes Comput. Sci.,4668,579-588.
22. Iglesias, J.,Eriksson, J.,Grize, F.,Tomassini, M.,Villa, A. E.(2005).Dynamics of pruning in simulated large-scale spiking neural networks.BioSystems,79,11-20.
23. Iglesias, J.,Villa, A. E. P.(2008).Emergence of preferred firing sequences in large spiking neural networks during simulated neuronal development.Int. J. Neural Syst.,18,267-277.
24. Iglesias, J.,Villa, A. E. P.(2007).Effect of stimulus-driven pruning on the detection of spatiotemporal patterns of activity in large neural networks.BioSystems,89,287-293.
25. Innocenti, G. M.(1995).Exuberant development of connections, and its possible permissive role in cortical evolution.Trends Neurosci.,18,397-402.
26. Innocenti, G. M.,Price, D. J.(2005).Exuberance in the development of cortical networks.Nat. Rev. Neurosci.,6,955-965.
27. Kryger, M.(ed.),Roth, T.(ed.),Dement, W. C.(ed.)(2005).Principles and Practice of Sleep Medicine.Philadelphia, PA:Elsevier Saunders.
28. Lamarche, C. H.,Ogilvie, R. D.(1997).Electrophysiological changes during the sleep onset period of psychophysiological insomniacs, psychiatric insomnias, and normal sleepers.Sleep,20,724-733.
29. Levitt, P.(2003).Structural and functional maturation of the developing primate brain.J. Pediatr.,143,S35-S45.
30. Low, L. K.,Cheng, H.-J.(2006).Axon pruning: an essential step underlying the developmental plasticity of neuronal connections.Philos. T. Roy. Soc.,361,1531-1544.
31. Merica, H.,Blois, R.,Gaillard, J. M.(1998).Spectral characteristics of sleep EEG in chronic insomnia.Eur. J. Neurosci.,10,1826-1834.
32. Miller, R.(ed.)(2000).Time and the Brain.Chur, Switzerland:Harwood Academic Publishers.
33. Mizuno, H.,Hirano, T.,Tagawa, Y.(2007).Evidence for activitydependent cortical wiring: formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity.J. Neurosci.,27,6760-6770.
34. Montgomery, J. M.,Madison, D. V.(2004).Discrete synaptic states define a major mechanism of synapse plasticity.Trends Neurosci.,27,744-750.
35. Morin, C. M.,Vallières, A.,Guay, B.,Ivers, H.,Savard, J.,Mérette, C.,Bastien, C.,Baillargeon, L.(2009).Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia.J. Am. Med. Assoc.,301,2005-2015.
36. Nofzinger, E. A.,Buysse, D. J.,Germain, A.,Price, J. C.,Miewald, J. M.,Kupfer, D. J.(2004).Functional neuroimaging evidence for hyperarousal in insomnia.Am. J. Psychiat.,161,2126-2129.
37. Nunez, P. L.,Srinivasan, R.(2006).Electric Fields of the Brain.Oxford University Press.
38. Perlis, M. L.,Smith, M. T.,Orff, H.,Andrews, P.,Giles, D. E.(2001).Beta/gamma activity in patients with insomnia and in good sleeper controls.Sleep,24,110-117.
39. Press, W. H.,Flannery, B. P.,Teukolsky, S. A.,Vetterling, W. T.(1992).Numerical recipes in C: The art of scientific computing.Cambridge, England:Cambridge University Press.
40. Ramakers, G. J.(2005).Neuronal network formation in human cerebral cortex.Prog. Brain Res.,147,1-14.
41. Roberts, P. D.,Bell, C. C.(2002).Spike timing dependent synaptic plasticity in biological systems.Biol. Cybern.,87,392-403.
42. Sanchez, E.,Perez-Uribe, A.,Upegui, A.,Thoma, Y.,Moreno, J. M.,Villa, A.,Volken, H.,Napieralski, A.,Sassatelli, G.,Lavarec, E.(2007).Perplexus: pervasive computing framework for modeling complex virtually-unbounded systems.AHS '07: Proceedings of the Second NASA/ESA Conference on Adaptive Hardware and Systems,Washington, DC, USA:
43. Shaposhnyk, V. V.,Dutoit, P.,Contreras-Lámus, V.,Perrig, S.,Villa, A. E. P.(2009).A framework for simulation and analysis of dynamically organized distributed neural networks.Lect. Notes Comput. Sci.,5768,277-286.
44. Shatz, C. J.(1990).Impulse activity and the patterning of connections during cns development.Neuron,5,745-756.
45. Tetko, I. V.,Villa, A. E.(2001).A pattern grouping algorithm for analysis of spatiotemporal patterns in neuronal spike trains. 1. detection of repeated patterns.J. Neurosci. Meth.,105,1-14.
46. Tetko, I. V.,Villa, A. E.(2001).A pattern grouping algorithm for analysis of spatiotemporal patterns in neuronal spike trains. 2. application to simultaneous single unit recordings.J. Neurosci. Meth.,105,15-24.
47. Torres, O.,Eriksson, J.,Moreno, J. M.,Villa, A. E.(2004).Hardware optimization and serial implementation of a novel spiking neuron model for the poetic tissue.BioSystems,76,201-208.
48. Villa, A. E. P.,Tetko, I. V.,Dutoit, P.,De Ribaupierre, Y.,De Ribaupierre, F.(1999).Corticofugal modulation of functional connectivity within the auditory thalamus of rat.J. Neurosci. Meth.,86,161-178.
49. Villa, A. E. P.,Tetko, I. V.,Dutoit, P.,Vantini, G.(2000).Non-linear cortico-cortical interactions modulated by cholinergic afferences from the rat basal forebrain.BioSystems,58,219-228.
50. Villa, A. E.,Tetko, I.,Hyland, B.,Najem, A.(1999).Spatiotemporal activity patterns of rat cortical neurons predict responses in a conditioned task.Proc. Natl. Acad. Sci. U.S.A.,96,1106-111.
51. Yamamori, T.,Rockland, K. S.(2006).Neocortical areas, layers, connections, and gene expression.Neurosci. Res.,55,11-27.