Effects of BCAA, Arginine and Carbohydrate Combined Drink on Post-Exercise Biochemical Response and Psychological Condition

10.4077/CJP.2011.AMK075

Mei-Chich Hsu；Kuei-Yu Chien；Cheng-Chen Hsu；Chia-Jung Chung；Kuei-Hui Chan；Borcherng Su

exhaustive exercise ； recovery ； branched-chain amino acid ； POMS ； T/C ratio

The Chinese Journal of Physiology

54卷2期（2011 / 04 / 01）

71 - 78

英文

This study investigated the effects of BCAA, arginine and carbohydrate combined beverage (BCAA Drink) on biochemical responses and psychological conditions during recovery after a single bout of exhaustive exercise. Fourteen healthy males were assigned to drink either BCAA Drink (BA trial) or placebo (PL trial) on two sessions separated by 2 weeks. Blood samples of each subject were collected before exercise, 0, 10, 20, 40, 60, 120 min and 24 h after exercise. No significant differences in the levels of lactate, ammonia, creatine kinase and glycerol between the two groups were observed at any of the time points. However, the levels of glucose and insulin were significantly higher in the BA trial as compared to those in the PL trial at the 40 and 60 min recovery points. Furthermore, the testosterone-to-cortisol ratio at the 120 min recovery point was significantly higher in the BA trial as compared to that in the PL trial. The results indicate the occurrence of anabolic response during the recovery period. The benefit of BCAA Drink was also performed by Profile of Mood States to assess the psychological condition. Fatigue score increased immediately at exhaustion in both groups, but the decrease in the fatigue score at 120 min recovery point was significant only in BA trial. These data indicate that a single bout of exhaustive exercise enhanced the feeling of fatigue. The detrimental consequence was reduced by an ingestion of BCAA Drink.

1. Tsai, P. H.,Tang, T. K.,Juang, C. L.,Chen, K. W. C.,Chi, C. A.,Hsu, M. C.(2009).Effects of arginine supplementation on post-exercise metabolic responses.Chinese J. Physiol.,52,136-142.
   連結：
2. Alvestrand, A.,Hagenfeldt, L.,Merli, M.,Oureshi, A.,Eriksoon, L. S.(1990).Influence of leucine infusion on intracellular amino acids in humans.Eur. J. Clin. Invest.,20,293-298.
3. Blomstrand, E.,Hassme''n, P.,Ek, S.,Ekblom, B.,Newsholme, E. A.(1997).Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise.Acta. Physiol. Scand.,159,41-49.
4. Borg, G. A.(1973).Perceived exertion: a note on "history" and methods.Med. Sci. Sports Exerc.,5,90-93.
5. Chan, K. H.,Wu, C. H.,Wang, C. C.(2010).Nutritional supplement use among professional baseball players in Taiwan.Med. Sci. Sports Exerc.
6. Coombes, J. S.,McNaughton, L. R.(2000).Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise.J. Sports Med. Phys. Fitness,40,240-246.
7. Coppack, S. W.,Jensen, M. D.,Miles, J. M.(1994).In vivo regulation of lipolysis in humans.J. Lipid Research,35,177-193.
8. Crozier, S. J.,Kimball, S. R.,Emmert, S. W.,Anthony, J. C.,Jefferson, L. S.(2005).Oral leucine administration stimulates protein synthesis in rat skeletal muscle.J. Nutr.,135,376-382.
9. Davis, J. M.,Bailey, S. P.,Woods, J. A.,Galiano, F. J.,Hamilton, M.,Bartoli, W. P.(1992).Effects of carbohydrate feedings on plasma free tryptophan and branched-chain amino acids during prolonged cycling.Eur. J. Appl. Physiol. Occup. Physiol.,65,513-519.
10. De Feo, P.,Di Loreto, C.,Lucidi, P.,Murdolo, G.,Parlanti, N.,De Cicco, A.,Piccioni, F.,Santeusanio, F.(2003).Metabolic response to exercise.J. Endocrinol. Invest.,26,851-854.
11. Dohm, G. L.(1986).Protein as a fuel for endurance exercise.Exer. Sports Sci. Rev.,14,143-173.
12. Epstein, Y.(1995).Clinical significance of serum creatine phosphokinase activity levels following exercise.Isr. J. Med. Sci.,31,698-699.
13. Floyd, J. C., Jr.,Fajans, S. S.,Conn, J. W.,Knopf, R. F.,Rull, J.(1966).Stimulation of insulin secretion by amino acids.J. Clin. Invest.,45,1487-1502.
14. Flynn, N. E.,Meininger, C. J.,Haynes, T. E.,Wu, G.(2002).The metabolic basis of arginine nutrition and pharmacotherapy.Biomed. Pharmacother.,56,427-438.
15. Fujita, S.,Dreyer, H. C.,Drummond, M. J.,Glynn, E. L.,Cadenas, J. G.,Yoshizawa, F.,Volpi, E.,Rasmussen, B. B.(2007).Nutrient signalling in the regulation of human muscle protein synthesis.J. Physiol.,582,813-823.
16. Gomez-Merino, D.,Bequet, F.,Berthelot, M.,Riverain, S.,Chennaoui, M.,Guezennec, C. Y.(2001).Evidence that the branched-chain amino acid L-valine prevents exercise-induced release of 5-HT in rat hippocampus.Int. J. Sports Med.,22,317-322.
17. Greer, B. K.,Woodard, J. L.,White, J. P.,Arguello, E. M.,Haymes, E. M.(2007).Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise.Int. J. Sport. Nutr. Exerc. Metab.,17,595-607.
18. Hamada, K.,Koba, T.,Sakurai, M.,Matsumoto, K.,Higuchi, T.,Imaizumi, K.,Hayase, H.,Ueno, H.(2005).Effective dose of branched-chain amino acids on blood response in healthy men.J. Jpn. Soc. Clin. Nutr.,27,1-10.
19. Hermans, M. P.,Schmeer, W.,Henquin, J. C.(1987).The permissive effect of glucose, tolbutamide and high K1 on arginine stimulation of insulin release in isolated mouse islets.Diabetologia,30,659-665.
20. Isidori, A.,Monaco, A. L.,Cappa, M.(1981).A study of growth hormone release in man after oral administration of amino acids.Curr. Med. Res. Opin.,7,475-481.
21. Keith, R. E.,O''keeffe, K. A.,Blessing, D. L.,Wilson, G. D.(1991).Alterations in dietary carbohydrate, protein, and fat intake and mood state in trained female cyclists.Med. Sci. Sports Exer.,23,212-216.
22. Kobayashi, R.,Murakami, T.,Obayashi, M.,Nakai, N.,Jaskiewicz, J.,Fujiwara, Y.,Shimomura, Y.,Harris, R. A.(2002).Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.Archives Biochem. Biophys.,407,231-240.
23. MacLean, D. A.,Graham, T. E.,Saltin, B.(1994).Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise.Am. J. Physiol.,267,E1010-E1022.
24. Madsen, K.,MacLean, D. A.,Kiens, B.,Christensen, D.(1996).Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km.J. Appl. Physiol.,81,2644-2650.
25. Matsumoto, K.,Koba, T.,Hamada, K.,Sakurai, M.,Higuchi, T.,Miyata, H.(2009).Branched-chain amino acid supplementation attenuates muscle soreness, muscle damage and inflammation during an intensive training program.J. Sports Med. Phys. Fitness,49,424-431.
26. Matsumoto, K.,Koba, T.,Hamada, K.,Tsujimoto, H.,Mitsuzono, R.(2009).Branched-chain amino acid supplementation increases the lactate threshold during an incremental exercise test in trained individuals.J. Nutr. Sci. Vitaminol.,55,52-58.
27. McConell, G. K.(2007).Effects of L-arginine supplementation on exercise metabolism.Curr. Opin. Clin. Nutr. Metab. Care.,10,46-51.
28. McNair, D. M.,Losr, M.,Droppleman, L. F.(1971).Profile of mood states manual.San Diego CA:Educational and Industrial Testing Service.
29. Meeusen, R.,Watson, P.,Dvorak, J.(2006).The brain and fatigue: new opportunities for nutritional interventions?.J. Sports Sci.,24,773-782.
30. Miller, R. H.,Block, K. P.(1984).Branched-chain amino acid metabolism.Annu. Rev. Nutr.,4,409-454.
31. Newsholme, E. A.,Blomstrand, E.(1995).Tryptophan 5-hydroxytryptamine and a possible explanation for central fatigue.Adv. Exp. Med. Biol.,384,315-320.
32. Noakes T. D.(1987).Effect of exercise on serum enzyme activities in humans.Sports Med.,4,245-267.
33. Pierce, P. A.(1995).Advances in Experimental Medicine and Biology.Fatigue: Neural and Muscular Mechanisms,New York, NY:
34. Platell, C.,Kong, S. E.,McCauley, R.,Hall, J. C.(2000).Branched-chain amino acids.J. Gastroenterol. Hepatol.,15,706-717.
35. Portier, H.,Chatard, J. C.,Filaire, E.,Jaunet-Devienne, M. F.,Robert, A.,Guezennec, C. Y.(2008).Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race.Eur. J. Appl. Physiol.,104,787-794.
36. Rivera-Brown, A. M.,Gutierrez, R.,Gutierrez, J. C.,Frontera, W. R.,Bar-Or, O.(1999).Drink composition, voluntary drinking, and fluid balance in exercising, trained, heat-acclimatized boys.J. Appl. Physiol.,86,78-84.
37. Rowell, L. B.(ed.),Shepherd, J. T.(ed.)(1996).Handbook of physiology, section 12: exercise: regulation and integration of multiple systems.New York, NY:Oxford University Press.
38. Shimomura, Y.,Yamamoto, Y.,Bajotto, G.,Sato, J.,Murakami, T.,Shimomura, N.,Kobayashi, H.,Mawatari, K.(2006).Nutraceutical effects of branched-chain amino acids on skeletal muscle.J. Nutrit.,136,529-532.
39. Sizer, F. S.,Whitney, E. N.(1997).Nutrition: concepts and controversies.Belmont:Wadsworth Publishing Company.
40. Urhausen, A.,Gabriel, H.,Kindermann, W.(1995).Blood hormones as markers of training stress and overtraining.Sports Med.,20,251-276.
41. Wang, H. T.,Chen, S. M.,Lee, S. D.,Hsu, M. C.,Chen, K. N.,Liou, Y. F.,Kuo, C. H.(2009).The role of DHEA-S in the mood adjustment against negative competition outcome in golfers.J. Sports Sci.,27,291-297.