Significant Association of Caveolin-1 Genotypes with Bladder Cancer Susceptibility in Taiwan

10.4077/CJP.2011.AMM009

Da-Tian Bau；Chao-Hsiang Chang；Ru-Yin Tsai；Hwei-Chung Wang；Rou-Fen Wang；Chia-Wen Tsai；Chun-Hsu Yao；Yueh-Sheng Chen；Song-Kun Shyue；Chih-Yang Huang

caveolin-1 ； polymorphism ； bladder cancer ； carcinogenesis

The Chinese Journal of Physiology

54卷3期（2011 / 06 / 01）

153 - 160

英文

Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on pathological grade. In this case-control study, the association of Cav-1 polymorphisms with bladder cancer risk in a central Taiwanese population was investigated. Three hundred and seventy-five patients with bladder cancer and the same number of age-and gender-matched healthy controls were genotyped. There were significant differences between bladder cancer and control groups in the distributions of their genotypes (P=1.0×10^(-12) and 0.299) and allelic frequencies (P=1.4×10^(-14) and 6.2×10^(-3)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for haplotype analysis, subjects who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of bladder cancer compared to subjects with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotypes with smoking status on individual bladder cancer susceptibility. This is the first report providing evidence that Cav-1 was involved in bladder cancer in that the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky haplotype for the development of bladder cancer and may be novel useful genomic markers for early detection of bladder cancer.

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