Association between "Ataxia Telangiectasia Mutated" Gene Polymorphisms and Childhood Leukemia in Taiwan

10.4077/CJP.2011.AMM106

Chung-Hsing Wang；Kang-Hsi Wu；Yung-Li Yang；Ching-Tien Peng；Fuu-Jen Tsai；Dong-Tsamn Lin；Chang-Fang Chiu；Cheng-Chieh Lin；Da-Tian Bau

ataxia telangiectasia mutated ； polymorphism ； childhood leukemia

The Chinese Journal of Physiology

54卷6期（2011 / 12 / 01）

413 - 418

英文

The ataxia telangiectasia mutated (ATM) gene plays a major role in repairing the double-strand breaks and maintaining the genome stability. In this case-control study, associations of seven ATM single-nucleotide polymorphisms (rs600931, rs189037, rs652311, rs624366, rs228589, rs227092 and rs227060) with risks in childhood leukemia in a Taiwanese population were investigated. Two hundred and sixty-six patients with childhood leukemia and 266 age-matched healthy controls recruited were genotyped and analyzed. The P-values of the distributions of the genotypic frequencies in the seven ATM polymorphisms were 0.8925, 0.2835, 0.5772, 0.8731, 0.3641, 0.9181 and 0.5071, respectively. The P-values of the distributions of the allelic frequencies in the seven ATM polymorphisms were 0.6158, 0.1179, 0.6971, 0.7944, 0.1887, 0.6605 and 0.2747, respectively. Although the results did not indicate that ATM polymorphism is directly associated with childhood leukemia, the gene-gene and gene-environment interactions of ATM with other factors is worthy of further investigation in the future.

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