题名

Association of Cyclooxygenase 2 Single-Nucleotide Polymorphisms and Hepatocellular Carcinoma in Taiwan

DOI

10.4077/CJP.2012.AMM056

作者

Wen-Shin Chang;Mei-Due Yang;Chia-Wen Tsai;Li-Hao Cheng;Long-Bin Jeng;Woei-Chung Lo;Chih-Hsueh Lin;Chih-Yang Huang;Da-Tian Bau

关键词

COX-2 ; polymorphism ; hepatocellular carcinoma

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

55卷1期(2012 / 02 / 01)

页次

1 - 7

内容语文

英文

英文摘要

Hepatocellular carcinoma (HCC) is a worldwide neoplasm for which early diagnosis is difficult and the prognosis is usually poor. Overexpression of cyclooxygenase 2 (COX-2) has been suggested to be associated with hepatocarcinogenesis. Although several COX-2 inhibitors have been used in hepatoma therapy, the genetic background between COX-2 and HCC remains largely unknown. In this study, the association of genotypic polymorphisms in COX-2 with HCC was investigated. 298 patients with HCC and 298 healthy controls recruited from the China Medical Hospital in Taiwan were genotyped by a PCR-RFLP method. We have investigated six polymorphic variants of COX-2, including A-1195G, G-765C, T+8473C, and variants in introns 1, 5 and 6, and analyzed the association of specific genotype(s) with susceptibility to HCC. The results showed that, for each of the six genotypes, no differences on distribution between the HCC and control groups were found. There was neither obvious joint effect of COX-2 G-765C/intron 6 haplotype nor its genotypes with smoking or alcohol consumption on HCC risk. Environmental factors, other than smoking and alcohol drinking, may affect the post-natal expression of COX-2 in the etiology of HCC, which is an outcome of complex genetic and environmental interactions. Moreover, our immunohistochemistrical results indicated that the COX-2 protein was significantly over-expressed in well-differentiated HCC, but not significantly increased in expression in poorly-differentiated HCC. We suggest that COX-2 may be a determinant of the differentiation grade of HCC.

主题分类 醫藥衛生 > 基礎醫學
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被引用次数
  1. Tsai, Chia-Wen,Shen, Wu-Chung,Liu, Shih-Ping,Liu, Juhn-Cherng,Li, Chi-Yuan,Hsu, Chin-Mu,Chang, Wen-Shin,Bau, Da-Tian(2015).Contribution of Double Strand Break Repair Gene XRCC3 Genotypes to Nasopharyngeal Carcinoma Risk in Taiwan.中國生理學雜誌,58(1),64-71.
  2. Yang, Hui-Ju,Lee, Meng-Chih,Kao, Erl-Shyh,Hu, Chao-Chin,Cheng, Chun-Yuan(2014).Inhibitory Effects of Scutellarein on Proliferation of Human Lung Cancer A549 Cells through ERK and NFκB Mediated by the EGFR Pathway.中國生理學雜誌,57(4),182-187.
  3. Ying, Tsung-Ho,Wang, Paulus S.,Tsai, Chia-Wen,Shui, Hao-Ai,Shih, Liang-Chun,Pan, Sin-Bao,Huang, Chung-Yu,Hsieh, Yi-Hsien,Ho, Chien-Yi,Chen, Ya-Chien,Chen, Chang-Peng,Chang, Wen-Shin,Bau, Da-Tian(2013).The Joint Effect of hOGG1 Genotype and Smoking Habit on Endometriosis in Taiwan.中國生理學雜誌,56(5),263-268.