Effects of High Concentration Oxygen Treatment on Traumatic Pneumothorax in Adult Rabbits

10.4077/CJP.2012.BAA032

Chung-Hung Shih；Wen-Hui Tsai；Seng-Wong Huang；Jan-Show Chu；Shau-Chieh Hsu；Hui-Chi Hsu

broncho-alveolar lavage ； inflammatory cytokine ； IL-1β ； IL-8 ； hyperoxia

The Chinese Journal of Physiology

55卷3期（2012 / 06 / 01）

178 - 183

英文

We undertook this study to investigate the adequate oxygen concentration that can be applied safely to the treatment of pneumothorax. Complete unilateral pneumothorax was induced artificially in rabbits, which were subsequently treated with various inspired oxygen fractions (FIO2; 21%, 60%, 80% or 100%). The pneumothorax resolution time was measured together with the levels of IL-1βand IL- 8 in broncho-alveolar lavage (BAL) and plasma samples. Furthermore, the lungs from these animals were examined for histolopathological evidence of oxygen toxicity. The results showed that the resolution time was significantly faster in the pneumothorax rabbits when treated with higher FIO2. Significantly higher levels of IL-1βwere detected in BAL samples collected from the pneumothoraxrabbits that had received FIO2 at levels of either 80% or 100% (P ＜ 0.05), but not in those with FIO2 at the 60% level. However, there was no significant change in the level of IL-8 in the BAL when the pneumothorax-rabbits were treated with different FIO2 levels. In addition, no evidence of oxygen toxicity was found when the lung tissues were examined. The data indicated that higher FIO2 treatment can accelerate the resolution of pneumothorax, but caution should be exercised with regard to associated oxygen toxicity when the FIO2 used is greater than 80%. We conclude that treatment with 60% FIO2 is an appropriate concentration for oxygen therapy for the treatment of pneumothorax in this model.

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