Cardiac Effects of Cupping: Myocardial Infarction, Arrhythmias, Heart Rate and Mean Arterial Blood Pressure in the Rat Heart

10.4077/CJP.2012.BAA042

Shahnaz Shekarforoush；Mohsen Foadoddini；Ali Noroozzadeh；Hassan Akbarinia；Ali Khoshbaten

cupping ； nonischemic stimuli ； cardioprotection

The Chinese Journal of Physiology

55卷4期（2012 / 08 / 01）

253 - 258

英文

This study was carried out to determine the effects of cupping on hemodynamic parameters, arrhythmias and infarct size (IS) after myocardial ischemic reperfusion injury in male rats. Rats were randomly subjected to dry or wet cupping. While dry cupping simply involved stimulation of the skin by suction, in wet cupping, scarification of the back skin was also carried out with a surgical blade and 0.5 ml blood was sucked out in each session. For ischemic reperfusion injury, rats were subjected to 30 min of left anterior descending coronary artery occlusion and 120 min of reperfusion. Our results show that cupping did not change the baseline heart rate or mean arterial blood pressure. Ischemic reperfusion injury caused an IS of 50 ± 5%, whereas dry cupping, single and repeated wet cupping significantly reduced IS to 28 ± 3%, 35 ± 3% and 22 ± 2% of area at risk, respectively. The rate of ischemic induced arrhythmias was significantly modified by wet cupping (P ＜ 0.05). These results indicate for the first time in rats that cupping might be cardioprotective in the ischemic reperfusion injury model.

1. Ahmed, S.M.,Madbouly, N.H.,Maklad, S.S.,Abu-Shady, E.A.(2005).Immunomodulatory effects of blood letting cupping therapy in patients with rheumatoid arthritis.Egypt J. Immunol.,12(2),39-51.
2. Banerjee, A.,Locke-Winter, C.,Rogers, K.B.,Mitchell, M.B.,Brew, E.C.,Cairns, C.B.,Bensard, D.D.,Harken, A.H.(1993).Preconditioning against myocardial dysfunction after ischemia and reperfusion by an α1-adrenergic mechanism.Circ. Res.,73,656-670.
3. Bankwala, Z.,Hale, S.L.,Kloner, R.A.(1994).Alpha1-Adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning.Circulation,90,1023-1028.
4. Canyon, S.J.,Dobson, G.P.(2004).Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat.Am. J. Physiol. Heart Circ.,287,H1286-H1295.
5. Foadoddini, M.,Esmailidehaj, M.,Mehrani, H.,Sadraei, S.H.,Golmanesh, L.,Wahhabaghai, H.,Valen, G.,Khoshbaten, A.(2010).Pretreatment with hyperoxia reduces in vivo infarct size and cell death by apoptosis with an early and delayed phase of protection.Eur. J. Cardiothorac. Surg.,39,233-240.
6. Jones, W.K.,Fan, G.C.,Liao, S.,Zhang, J.M.,Wang, Y.,Weintraub, N.L.,Kranias, E.G.,Schultz, J.E.,Lorenz, J.,Ren, X.(2009).Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation,120,S1-S9.
7. Lee, M.S.,Choi, T.Y.,Shin, B.C.,Kim, J.I.,Nam, S.S.(2010).Cupping for hypertension: a systematic review.Clin. Exp. Hypertens.,32,423-425.
8. Meerson, F.Z.,Malyshev, I.Y.(1989).Adaptation to stress increases the heart resistance to ischemic and reperfusion arrhythmias.J. Mol. Cell. Cardiol.,21,299-303.
9. Michalsen, A.,Bock, S.,Lüdtke, R.,Rampp, T.,Baecker, M.,Bachmann, J.,Langhorst, J.,Musial, F.,Dobos, G.J.(2009).Effects of traditional cupping therapy in patients with carpal tunnel syndrome: a randomized controlled trial.J. Pain,10(6),601-608.
10. Oxman, T.,Arad, M.,Klein, R.,Avazov, N.,Rabinowitz, B.(1997).Limb ischemia preconditions the heart against reperfusion tachyarrhythmia.Am. J. Physiol. Heart Circ. Physiol.,273,H1707-H1712.
11. Ren, X.,Wang, Y.,Jones, W.K.(2004).TNF-α is required for late ischemic preconditioning but not for remote preconditioning of trauma.J. Surg. Res.,121,120-129.
12. Scognamillo-Szabó, M.V.R.,Bechara, G.H.,Cunha, F.Q.(2005).Effect of acupuncture on TNF-α, IL-1β and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats.Ciência Rural,35,103-108.
13. Tham, L.M.,Lee, H.P.,Lu, C.(2006).Cupping: from a biomechanical perspective.J. Biomech.,39,2183-2193.
14. Ullah, K.,Younis, A.,Wali, M.(2007).An investigation into the effect of cupping therapy as a treatment for anterior knee pain and its potential role in health promotion.Int. J. Altern. Med.,4(1)
15. Vogel, J.H.K.,Bolling, S.F.,Costello, R.B.,Guarneri, E.M.,Krucoff, M.W.,Longhurst, J.C.,Olshansky, B.,Pelletier, K.R.,Tracy, C.M.,Vogel, R.A.(2005).Integrating complementary medicine into cardiovascular medicine: a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents.J. Am. Coll. Cardiol.,46,184-221.
16. Walker, M.J.,Curtis, M.J.,Hearse, D.J.,Campbell, R.W.F.,Janse, M.J.,Yellon, D.M.,Cobbe, S.M.,Coker, S.J.,Harness, J.B.,Harron, D.W.G.,Higgins, A.J.,Julian, D.G.,Lab, M.J.,Manning, A.S.,Northover, B.J.,Parratt, J.R.,Riemersma, R.A.,Riva, E.,Russell, D.C.,Sheridan, D.J.,Winslow, E.,Woodward, B.(1988).The Lambeth conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion.Cardiovasc. Res.,22,447-455.
17. Yin, L.H.,Miao, B.H.,Chen, J.,Chai, T.Q.(2009).Clinical study about acupuncture combined with cupping therapy for treating stable exertional angina pectoris in the middle-age or old patients (Abstract).Chinese J. Clin. Healthcare,12(5),465-467.
18. Yoo, S.S.,Tausk, F.(2004).Cupping: east meets west.Int. J. Dermatol.,43,664-665.

1. Sant'Ana, Paula Grippa,Sá, Felipe Gonçalves dos Santos de,Mota, Gustavo Ribeiro da,Marocolo, Moacir,Cunha, Márcia Regina Holanda da,Castardeli, Edson(2014).Training and Cardiovascular Responses from Cigarette Smoke Exposure.中國生理學雜誌,57(6),315-319.
2. Vividha Dhapte,Piyush Mehta(2015).Cupping therapy: A prudent remedy for a plethora of medical ailments.Journal of Traditional and Complementary Medicine,5(3),127-134.
3. Yang, Kun-Ta,Tu, Wei-Chia,Shen, Yan-Jhih,Cheng, Ching-Feng,Chen, Tsung-I,Chen, Michael Yu-Chih(2015).Role of Sodium-Hydrogen Exchanger-1 (NHE-1) in the Effect of Exercise on Intermittent Hypoxia-Induced Left Ventricular Dysfunction.中國生理學雜誌,58(4),254-262.
4. Yang, Kun-Ta,Tu, Wei-Chia,Shen, Yan-Jhih,Cheng, Ching-Feng,Chen, Tsung-I,Chen, Michael Yu-Chih(2015).Role of Sodium-Hydrogen Exchanger-1 (NHE-1) in the Effect of Exercise on Intermittent Hypoxia-Induced Left Ventricular Dysfunction.中國生理學雜誌,58(4),254-262.