Effects of Nanogold on the Alleviation of Carbon Tetrachloride-Induced Hepatic Injury in Rats

10.4077/CJP.2012.BAA064

Yi-Peng Chen；Zong-Her Dai；Pan-Chen Liu；Jiunn-Jye Chuu；Kuo-Yang Lee；Shun-Lai Lee；Yun-Ju Chen

alanine aminotransferase ； aspartate aminotransferase ； hepatic injury ； IL-10 ； nanogold

The Chinese Journal of Physiology

55卷5期（2012 / 10 / 01）

331 - 336

英文

Gold particles have been used in complementary medicine for decades, and many beneficial effects have been reported. Our present study sought to evaluate the therapeutic effects of nanogold in carbon tetrachloride (CCl4)-injured liver of rats. Male SD rats were subjected to liver injury induction by CCl4, then the rats were fed with zero to high dose (0, 1, 5 or 10 ppm) of nanogold water every day for 4 weeks. Biochemical analyses on liver functions were then performed to evaluate the therapeutic effects of nanogold. Our results revealed that gold nanoparticles lowered serum aspartate aminotransaminase (AST) and alanine aminotransferase and exerted serum total protein-recovering effects, which might be partially associated with the elevation of anti-inflammatory cytokine IL-10 level. In addition, serum triglyceride level fell after continuous ingestion of nanogold. Finally, the experimental animals recovered body weight after 4 weeks of nanogold ingestion. This is the first report indicating inflammationalleviating effects of nanogold on hepatic injury.

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