Suppression of TLR-4-Related Inflammatory Pathway and Anti-Fibrosis Effects of Probiotic-Fermented Purple Sweet Potato Yogurt in Hearts of Spontaneously Hypertensive Rats

10.4077/CJP.2013.BAB118

Pei-Pei Lin；You-Miin Hsieh；Wei-Wen Kuo；Yueh-Min Lin；Yu-Lan Yeh；Chien-Chung Lin；Fuu-Jen Tsai；Chang-Hai Tsai；Cheng-Chih Tsai；Chih-Yang Huang

hypertension ； inflammation ； fibrosis ； lactic acid bacteria ； TLR-4 ； purple sweet potato

The Chinese Journal of Physiology

56卷3期（2013 / 06 / 30）

174 - 183

英文

Inflammation plays an important role in triggering fibrosis of cardiovascular disease and hypertension. Gamma-aminobutyric acid (GABA) has hypotensive effect; GABA concentration could be enhanced in milk fermented with lactic acid bacteria (LAB). This study evaluated the effect of probiotic-fermented purple sweet potato yogurt (PSPY) on the toll-like receptor 4 (TLR-4)-related inflammatory components, and on fibrosis in the heart of spontaneously hypertensive rat (SHR). TLR4-related pathway and fibrosis-associated proteins TGFβ and FGF2 were significantly increased in SHR hearts, but were highly suppressed in 10% PSPY-fed rats. Microscopic examination with Masson trichrome staining of left ventricle further demonstrated that 10% and 100% PSPY both significantly reduced interstitial fibrosis in SHR hearts. These findings indicated that oral administration of 10% probiotic-fermented PSPY was strong enough to lower cardiac fibrosis in SHR rats through the suppression of TLR-4-related inflammatory pathway. Therefore, PSPY may be included in diets to help prevent cardiac fibrosis in patients with hypertension.

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