Diminished Contractile Responses of Isolated Conduit Arteries in Two Rat Models of Hypertension

10.4077/CJP.2013.BAB128

Anna Zemančíková；Jozef Török

contraction ； isometric force ； large arteries ； noradrenaline ； NO-synthase blockade ； smooth muscle ； spontaneously hypertensive rat

The Chinese Journal of Physiology

56卷4期（2013 / 08 / 31）

230 - 235

英文

Hypertension is accompanied by thickening of arteries, resulting in marked changes in their passive and active mechanical properties. The aim of this study was to demonstrate that the large conduit arteries from hypertensive individuals may not exhibit enhanced contractions in vitro, as is often claimed. Mechanical responses to vasoconstrictor stimuli were measured under isometric conditions using ring arterial segments isolated from spontaneously hypertensive rats, N^ω-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats, and untreated Wistar rats serving as normotensive control. We found that thoracic aortas from both types of hypertensive rats had a greater sensitivity but diminished maximal developed tension in response to noradrenaline, when compared with that from normotensive rats. In superior mesenteric arteries, the sensitivity to noradrenaline was similar in all examined rat groups but in L-NAME-treated rats, these arteries exhibited decreased active force when stimulated with high noradrenaline concentrations, or with 100 mM KCl. These results indicate that hypertension leads to specific biomechanical alterations in diverse arterial types which are reflected in different modifications in their contractile properties.

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