The Joint Effect of hOGG1 Genotype and Smoking Habit on Endometriosis in Taiwan

10.4077/CJP.2013.BAB142

Chia-Wen Tsai；Chien-Yi Ho；Liang-Chun Shih；Tsung-Ho Ying；Yi-Hsien Hsieh；Ya-Chien Chen；Wen-Shin Chang；Chung-Yu Huang；Sin-Bao Pan；Hao-Ai Shui；Chang-Peng Chen；Paulus S. Wang；Da-Tian Bau

endometriosis ； hOGG1 ； single nucleotide polymorphism ； smoking

The Chinese Journal of Physiology

56卷5期（2013 / 10 / 31）

263 - 268

英文

This study has two aims: [1] to evaluate the association between hOGG1 genotypic polymorphism and endometriosis risk, and [2] to investigate the joint effects of hOGG1 genotype and smoking habit on endometriosis susceptibility in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was genotyped and analyzed of its association with the risk of endometriosis. In total, 153 patients with endometriosis and 636 non-endometriosis healthy controls were recruited and genotyped. The methodology for genotyping is polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Pearson's Chi-square test was performed to compare the distributions of the genotypes between case and control groups. The results showed that the hOGG1 codon 326 genotypes were not differently distributed between the endometriosis and non-endometriosis control groups in both genotypic (P = 0.6212) and allelic (P = 0.4006) frequency analysis. We have further analyzed the genotypic-smoking joint effects on endometriosis risk and found an obvious interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 genotypes were increased in endometriosis risk only in the smoker groups (P = 0.0061), but not in the non-chewer group (P = 0.0648). Our results provide the evidence that the hOGG1 codon 326 genotype may have a joint effect with smoking on the development of endometriosis.

1. Bau, D.T.,Chang, C.H.,Tsai, R.Y.,Wang, H.C.,Wang, R.F.,Tsai, C.W.,Yao, C.H.,Chen, Y.S.,Shyue, S.K.,Huang, C.Y.(2011).Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan.Chinese J. Physiol.,54,153-160.
   連結：
2. Bau, D.T.,Hsieh, Y.Y.,Wan, L.,Wang, R.F.,Liao, C.C.,Lee, C.C.,Lin, C.C.,Tsai, C.H.,Tsai, F.J.(2007).Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis.Chinese J. Physiol.,50,326-329.
   連結：
3. Bau, D.T.,Tsai, M.H.,Huang, C.Y.,Lee, C.C.,Tseng, H.C.,Lo, Y.L.,Tsai, Y.,Tsai, F.J.(2007).Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: evidence for modification of smoking habit.Chinese J. Physiol.,50,294-300.
   連結：
4. Bau, D.T.,Wang, H.C.,Liu, C.S.,Chang, C.L.,Chiang, S.Y.,Wang, R.F.,Tsai, C.W.,Lo, Y.L.,Hsiung, C.A.,Lin, C.C.,Huang, C.Y.(2009).Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan.Chinese J. Physiol.,52,411-418.
   連結：
5. Chang, W.S.,Yang, M.D.,Tsai, C.W.,Cheng, L.H.,Jeng, L.B.,Lo, W.C.,Lin, C.H.,Huang, C.Y.,Bau, D.T.(2012).Association of cyclooxygenase 2 single-nucleotide polymorphisms and hepatocellular carcinoma in Taiwan.Chinese J. Physiol.,55,1-7.
   連結：
6. Lin, H.H.,Ke, H.L.,Hsiao, K.H.,Tsai, C.W.,Wu, W.J.,Bau, D.T.,Chang, L.L.(2011).Potential role of CCND1 G870A genotype as a predictor for urothelial carcinoma susceptibility and muscleinvasiveness in Taiwan.Chinese J. Physiol.,54,196-202.
   連結：
7. Wang, C.H.,Wu, K.H.,Yang, Y.L.,Peng, C.T.,Tsai, F.J.,Lin, D.T.,Chiu, C.F.,Lin, C.C.,Bau, D.T.(2011).Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan.Chinese J. Physiol.,54,413-418.
   連結：
8. Wang, H.C.,Liu, C.S.,Wang, C.H.,Tsai, R.Y.,Tsai, C.W.,Wang, R.F.,Chang, C.H.,Chen, Y.S.,Chiu, C.F.,Bau, D.T.,Huang, C.Y.(2010).Significant association of XPD Asp312Asn polymorphism with breast cancer in Taiwanese patients.Chinese J. Physiol.,53,130-135.
   連結：
9. Arizono, K.,Osada, Y.,Kuroda, Y.(2008).DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population.Jpn. J. Clin. Oncol.,38,186-191.
10. Barbosa, C.P.,de Souza, A.M.B.,Bianco, B.,Christofolini, D.,Bach, F.A.M.,de Lima, G.R.(2009).Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values.Sao Paulo Med. J.,127,342-345.
11. Barbosa, C.P.,de Souza, A.M.B.,Bianco, B.,Christofolini, D.M.,Mafra, F.A.,de Lima, G.R.(2010).OC-125 immunostaining in endometriotic lesion samples.Arch. Gynecol. Obstet.,281,43-47.
12. Bau, D.T.,Tsai, M.H.,Lo, Y.L.,Hsu, C.M.,Tsai, Y.,Lee, C.C.,Tsai, F.J.(2007).Association of p53 and p21 (CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients.Anticancer Res.,27,1559-1564.
13. Boiteux, S.,Radicella, J.P.(2000).The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.Arch. Biochem. Biophys.,377,1-8.
14. Chang, C.H.,Chang, C.L.,Tsai, C.W.,Wu, H.C.,Chiu, C.F.,Wang, R.F.,Liu, C.S.,Lin, C.C.,Bau, D.T.(2009).Significant association of an XRCC4 single nucleotide polymorphism with bladder cancer susceptibility in Taiwan.Anticancer Res.,29,1777-1782.
15. Chang, C.H.,Chiu, C.F.,Liang, S.Y.,Wu, H.C.,Chang, C.L.,Tsai, C.W.,Wang, H.C.,Lee, H.Z.,Bau, D.T.(2009).Significant association of Ku80 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan.Anticancer Res.,29,1275-1279.
16. Chen, L.,Elahi, A.,Pow-Sang, J.,Lazarus, P.,Park, J.(2003).Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer.J. Urol.,170,2471-2474.
17. Dianov, G.L.,Souza-Pinto, N.,Nyaga, S.G.,Thybo, T.,Stevnsner, T.,Bohr, V.A.(2001).Base excision repair in nuclear and mitochondrial DNA.Prog. Nucl. Res. Molec. Biol.,68,285-297.
18. Elahi, A.,Zheng, Z.,Park, J.,Eyring, K.,McCaffrey, T.,Lazarus, P.(2002).The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk.Carcinogenesis,23,1229-1234.
19. Gao, L.,Li, K.,Li, F.,Li, H.,Liu, L.,Wang, L.,Zhang, Z.,Gao, T.,Liu, Y.(2010).Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients.J. Dermatol. Sci.,57,51-56.
20. Goode, E.L.,Ulrich, C.M.,Potter, J.D.(2002).Polymorphisms in DNA repair genes and associations with cancer risk.Cancer Epidemiol. Biomarkers Prev.,11,1513-1530.
21. Hsieh, Y.Y.,Bau, D.T.,Chang, C.C.,Tsai, C.H.,Chen, C.P.,Tsai, F.J.(2008).XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis.Mol. Reprod. Dev.,75,946-951.
22. Kohno, T.,Shinmura, K.,Tosaka, M.,Tani, M.,Kim, S.R.,Sugimura, H.,Nohmi, T.,Kasai, H.,Yokota, J.(1998).Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.Oncogene,16,3219-3225.
23. Li, H.,Hao, X.,Zhang, W.,Wei, Q.,Chen, K.(2008).The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis.Cancer Epidemiol. Biomarkers Prev.,17,1739-1745.
24. Liu, C.J.,Hsia, T.C.,Tsai, R.Y.,Sun, S.S.,Wang, C.H.,Lin, C.C.,Tsai, C.W.,Huang, C.Y.,Hsu, C.M.,Bau, D.T.(2010).The joint effect of hOGG1 single nucleotide polymorphism and smoking habit on lung cancer in Taiwan.Anticancer Res.,30,4141-4145.
25. Ni, M.,Qiu, J.,He, W.,Wang, X.(2012).The functional Ser326Cys polymorphism in hOGG1 is associated with gastric cancer risk: evidence from 1180 cases and 2444 controls.Eur. J. Gastroenterol. Hepatol.,24,683-687.
26. Sakamoto, T.,Higaki, Y.,Hara, M.,Ichiba, M.,Horita, M.,Mizuta, T.,Eguchi, Y.,Yasutake, T.,Ozaki, I.,Yamamoto, K.,Onohara, S.,Kawazoe, S.,Shigematsu, H.,Koizumi, S.,Tanaka, K.(2006).hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among Japanese.J. Epidemiol.,16,233-239.
27. Tseng, H.C.,Tsai, M.H.,Chiu, C.F.,Wang, C.H.,Chang, N.W.,Huang, C.Y.,Tsai, C.W.,Liang, S.Y.,Wang, C.L.,Bau, D.T.(2008).Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.Anticancer Res.,28,1687-1691.
28. Tsou, Y.A.,Hua, C.H.,Tseng, H.C.,Hsu, C.F.,Tsai, C.W.,Sun, S.S.,Tsai, R.Y.,Tsai, M.H.,Bau, D.T.(2010).The joint effect of hOGG1 single nucleotide polymorphism and betel quid chewing on oral cancer in Taiwan.Anticancer Res.,30,4205-4208.
29. Wang, W.,Wang, M.,Chen, Y.,Zhang, Z.,Wang, S.,Xu, M.,Wang, B.,Zhao, Q.,Zhang, Z.(2012).The hOGG1 Ser326Cys polymorphism contributes to cancer susceptibility: evidence from 83 case-control studies.Mutagenesis,27,329-336.
30. Weiss, J.M.,Goode, E.L.,Ladiges, W.C.,Ulrich, C.M.(2005).Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.Mol. Carcinog.,42,127-141.
31. Xu, B.,Tong, N.,Chen, S.Q.,Yang, Y.,Zhang, X.W.,Liu, J.,Hu, X.N.,Sha, G.Z.,Chen, M.(2012).Contribution of HOGG1 Ser326Cys polymorphism to the development of prostate cancer in smokers: meta-analysis of 2779 cases and 3484 controls.PLoS One,7,e30309.
32. Xu, J.,Zheng, S.L.,Turner, A.,Isaacs, S.D.,Wiley, K.E.,Hawkins, G.A.,Chang, B.L.,Bleecker, E.R.,Walsh, P.C.,Meyers, D.A.,Isaacs, W.B.(2002).Associations between hOGG1 sequence variants and prostate cancer susceptibility.Cancer Res.,62,2253-2257.
33. Yamane, A.,Kohno, T.,Ito, K.,Sunaga, N.,Aoki, K.,Yoshimura, K.,Murakami, H.,Nojima, Y.,Yokota, J.(2004).Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo.Carcinogenesis,25,1689-1694.
34. Yang, M.D.,Hsu, Y.M.,Kuo, Y.S.,Chen, H.S.,Chang, C.L.,Wu, C.N.,Chang, C.H.,Liao, Y.M.,Wang, H.C.,Wang, M.F.,Bau, D.T.(2009).Significant association of Ku80 single nucleotide polymorphisms with colorectal cancer susceptibility in Central Taiwan.Anticancer Res.,29,2239-2242.
35. Ying, T.H.,Tseng, C.J.,Tsai, S.J.,Hsieh, S.C.,Lee, H.Z.,Hsieh, Y.H.,Bau, D.T.(2011).Association of p53 and CDKN1A genotypes with endometriosis.Anticancer Res.,31,4301-4306.

1. Tsai, Chia-Wen,Shen, Wu-Chung,Liu, Shih-Ping,Liu, Juhn-Cherng,Li, Chi-Yuan,Hsu, Chin-Mu,Chang, Wen-Shin,Bau, Da-Tian(2015).Contribution of Double Strand Break Repair Gene XRCC3 Genotypes to Nasopharyngeal Carcinoma Risk in Taiwan.中國生理學雜誌,58(1),64-71.
2. Yeh, Diana Yu-Wung,Lin, Shih-Sen,Lin, Chen-Chun,Chen, Yu-Ching,Chang, Yih-Leong(2014).Crystal Amphetamine Smoking-Induced Acute Eosinophilic Pneumonia and Diffuse Alveolar Damage: A Case Report and Literature Review.中國生理學雜誌,57(5),295-298.
3. Yeh, Yu-Lan,Wen, Su-Ying,Pai, Pei-ying,Liao, Hung-En,Lai, Chao-Hung,Kuo, Wu-Hsien,Jong, Gwo-Ping,Huang, Chih-Yang,Ho, Tsung-Jung,Chung, Li-Chin(2015).Cardio Protective Effects of Lumbrokinase and Dilong on Second-Hand Smoke-Induced Apoptotic Signaling in the Heart of a Rat Model.中國生理學雜誌,58(3),188-196.