题名

Cardiac Hypertrophy-Related Pathways in Obesity

DOI

10.4077/CJP.2014.BAB146

作者

Wei-Kung Chen；Yu-Lan Yeh；Yueh-Min Lin；Jing-Ying Lin；Bor-Show Tzang；James A. Lin；Ai-Lun Yang；Fong-Li Wu；Fuu-Jen Tsai；Shiu-Min Cheng；Chih-Yang Huang；Shin-Da Lee

关键词

calcineurin ； ERK5 ； heart ； hypertrophy ； IL-6 ； MEK5 ； NFAT3 ； signaling

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

57卷3期（2014 / 06 / 30）

页次

111 - 120

内容语文

英文
英文摘要

Obesity is often associated with the development of cardiac hypertrophy but the hypertrophyrelated pathways in obesity remain unknown. The purpose of this study was to evaluate cardiac hypertrophy-related markers, atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), tumor necrosis factor-alpha (TNFα) and hypertrophy-related pathways, interleukin (IL)-6-STAT3, IL-6-MEK5-ERK5 and calcineurin-nuclear factor of activated T-cells (NFAT)3 in the excised hearts from obese rats. Twelve obese Zucker rats were studied at 5-6 months of age and twelve age-matched lean Zucker rats served as the control group. The cardiac characteristics, myocardial architecture, ANP, BNP, TNFα levels, IL-6, STAT3, p-STAT3, MEK5, ERK5, p-ERK5, calcineurin and NFAT3 in the left ventricle from the rats were measured by heart weight index, echocardiography, vertical cross section, histological analysis, reverse transcription polymerase chain reaction and Western blotting. Compared with the lean control, the whole heart weight, the left ventricule weight, the ratio of the whole heart weight to tibia length, echocardiographic interventricular septum, left ventricular posterior wall thickness, myocardial morphological changes and systolic blood pressure were found to increase in the obese rats. The protein levels of ANP, BNP, TNFα, IL-6, STAT3, p-STAT3, MEK5, ERK5, p-ERK5, calcineurin and NFAT3 were also significantly increased in the hearts of the obese rats. The results showed that the hypertrophy-related markers, ANP, BNP and TNFα, the hypertrophy-related pathways IL-6-STAT3 and IL-6-MEK5-ERK5, and the calcineurin-NFAT3 hypertrophy-related pathways were more active in obese Zucker rats, which may provide possible hypertrophic mechanisms for developing cardiac hypertrophy and pathological changes in obesity.
主题分类 醫藥衛生 > 基礎醫學
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被引用次数
  1. 張繼豪(2011)。新穎先進的金屬防蝕塗料：仿生超疏水高分子以及氣體阻隔聚苯胺／類石墨烯複合材料。中原大學化學系學位論文。2011。1-260。 
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