题名

Effects of Chronic Treatment with Diosgenin on Bone Loss in a D-Galactose-Induced Aging Rat Model

DOI

10.4077/CJP.2014.BAC199

作者

Ying-Tzu Hung；Maria A Tikhonova；Shinn-Jyh Ding；Pan-Fu Kao；Howard Haw-Chang Lan；Jiuan-Miaw Liao；Jian-Horng Chen；Tamara G Amstislavskaya；Ying-Jui Ho

关键词

aging ； bone loss ； D-galactose ； diosgenin ； osteoporosis

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

57卷3期（2014 / 06 / 30）

页次

121 - 127

内容语文

英文
英文摘要

D-galactose is known to cause oxidative stress and induce aging-related diseases. Our previous study demonstrated that diosgenin can prevent osteoporosis in menopausal rats. The aim of the present study was to determine the effects of oral administration of diosgenin on bone loss in a D-galactoseinduced aging rat model. Three groups of twelve-week-old male Wistar rats received a daily injection of D-galactose (150 mg/kg/day, i.p.) and orally administered diosgenin (0, 10, or 50 mg/kg/day) for eight weeks, while a control group received saline injection (1 ml/kg/day, i.p.), then the femurs were taken to measure mechanical and morphological properties. The results showed that frame volume and femur volume decreased and porosity and frame density increased in the D-galactose-induced aging rats compared to controls and that these effects were prevented by co-administration of diosgenin. This suggests that diosgenin might prevent bone loss during aging and provide beneficial effects in osteoporosis in the elderly.
主题分类 醫藥衛生 > 基礎醫學
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被引用次数
  1. Yao, Chun-Hsu,Sen, Yang,Huang, Teng-Le,Huang, Chih-Yang,Hu, Chung-Hsuan,Ho, Chien-Yi,Chan, Tzu-Min,Yao, Chun-Hsu,Sen, Yang,Huang, Teng-Le,Huang, Chih-Yang,Hu, Chung-Hsuan,Ho, Chien-Yi,Chan, Tzu-Min(2016).Effects of Different Concentrations of Collagenous Peptide from Fish Scales on Osteoblast Proliferation and Osteoclast Resorption.中國生理學雜誌,59(4),191-201.
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