Crystal Amphetamine Smoking-Induced Acute Eosinophilic Pneumonia and Diffuse Alveolar Damage: A Case Report and Literature Review

10.4077/CJP.2014.BAC201

Shih-Sen Lin；Yu-Ching Chen；Yih-Leong Chang；Diana Yu-Wung Yeh；Chen-Chun Lin

acute eosinophilic pneumonia ； amphetamine ； diffuse alveolar damage ； free radicals

The Chinese Journal of Physiology

57卷5期（2014 / 10 / 31）

295 - 298

英文

Eosinophilic pneumonia (EP) is a disease characterized by prominent infiltration of lung structures by eosinophils. The lung interstitium is infiltrated by eosinophils, and essentially the alveolar spaces are filled with eosinophils and a fibrinous exudate, with conservation of the global architecture of the lung. Diagnosis of EP relies on pathological demonstration of alveolar eosinophilia along with characteristic clinical manifestations of nonproductive cough, dyspnea, chest pain and/or unique imaging features. EP may be categorized according to the origin: EP of undetermined origin may overlap with well-individualized syndromes, while EP with a definite cause is mainly due to infections or drug abuse. Here, we report a case of an amphetamine abuser who developed acute EP and acute respiratory distress syndrome after amphetamine inhalation. Related studies on the pathogenesis of stimulant-related lung injury and treatment strategies are also discussed.

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