Effects of Periodontal Treatment on Glycemic Control in Type 2 Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials

10.4077/CJP.2014.BAC262

Qiu-Ying Sun；Mei Feng；Ming-Zhi Zhang；Yan-Qing Zhang；Ming-Feng Cao；Li-Xiang Bian；Qing-Bo Guan；Kai-Ian Song

diabetes ； glyco sylated hemoglobin ； meta-analysis ； periodontal treatment

The Chinese Journal of Physiology

57卷6期（2014 / 12 / 31）

305 - 314

英文

The association between diabetes and inflammatory periodontal diseases has been studied extensively. However, there is a lack of robustness and homogeneity among studies describing effects of periodontal treatment on glycemic control. The aim of this study was to carry out a meta-analysis to understand whether periodontal treatment could improve glycemic control in type 2 diabetic patients. Electronic searches were carried out on MEDLINE, EMBASE and the Cochrane central register of controlled trials from 1980 to July 2012. Randomized controlled trials of periodontal therapy on glycemic control in diabetic patients with a minimum of 3 months of follow-up were included. Meta-analysis was carried out with 8 studies involving SIS participants using Sta ta 11.0 software. Our results showed that periodontal treatment could lead to a significant decrease in HbAlc level. The standardized mean difference between intervention groups and control groups was significant: 1.03% (95% confidence interval : 0.31% to 1.70%, P=0.003) from baseline to 3 months, and 1.18% (95% confidence interval: 0.72 % to 1.64%, P＜0.001) from baseline to 6 months. Periodontal treatment could lead to a non-significant de crease in fasting plasma glucose (FPC) levels from baseline to 3 months. The standardized mean difference between the intervention and the control group was 0.69 mg/dl (95% confidence interval: -0 .27 mg/dl to 1.66 mg/dl, P=0.158). Our analysis indicated that periodontal treatment could improve glycemic control in type 2 diabetic patients with periodontal diseases.

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