Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats with Aortic Constriction

10.4077/CJP.2014.BAD268

Yanling Zhang；Bing Li；Bingxiang Wang；Jingjun Zhang；Junyan Wu；Trefor Morgan

ACE2 ； aortic constriction ； fibrosis ； hypertension ； hypertrophy

The Chinese Journal of Physiology

57卷6期（2014 / 12 / 31）

335 - 342

英文

The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and function s. To assess the role of the angiotensin-converting enzyme 2 (ACE2)-Mas receptor axis in the regulation of cardiac structure and function , the present work investigated the ex press ion of ACE2 and Ma s receptor in the heart in the cardiac remodeling that occurs in aortic constricted rats. Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively. Results showed that aortic constriction increased left ventricular hypertrophy, fibrosis, mean arterial pressure (MAP ), plasma renin activity (PRA) and cardiac ACE levels, but decreased the express ion of cardiac ACE2 and Ma s receptor. Losartan treatment significantly decreased MA P, left ventricle hypertrophy (LVH), fibrosis, and increased cardiac ACE2 and Ma s expression. Enalapril also improved the cardiac parameters with a rise in cardiac ACE2, but did not change the Ma s level. In conclusion, aortic constriction results in cardiac hypertrophy, fibro sis and a rise of cardiac ACE expression. Both AT] receptor blocker and ACE inhibitor play a cardioprotective role in aortic constriction. However, ATI receptor blocker particularly promotes cardiac ACE2 and Mas receptor levels. AC E inhibitor is associated with the inhibition of ACE and normalization of cardiac ACE2 activity.

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