题名

Dopaminergic Facilitation of GABAergic Transmission in Layer III of Rat Medial Entorhinal Cortex

DOI

10.4077/CJP.2015.BAC241

作者

Hai-bo Li;Lin Lin;Li-ye Yang;Chao Xie

关键词

dopamine ; GABAergic transmission ; medial entorhinal cortex ; mIPSCs ; sIPSCs

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

58卷1期(2015 / 02 / 01)

页次

46 - 54

内容语文

英文

英文摘要

The medial entorhinal cortex (MEC) receives a dense dopaminergic innervation and expresses dopamine receptors. However, little is known about the effect of dopamine on GABAergic transmission in this region of the brain. In this study, we recorded GABAA receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) by using whole-cell patch-clamp technique. Application of dopamine at 10μM and 100μM significantly increased the frequency and amplitude of sIPSCs. This effect of dopamine is primarily mediated by acting at D1-like dopamine receptors, but not D2-like and α1 adrenergic receptors, since dopamine-induced increased in frequency and amplitude of the sIPSCs was completely blocked by D1-like, but not D2-like or α1 adrenergic, receptor antagonist. However, application of dopamine did not affect the frequency and amplitude of the mIPSCs, implying that the effect of dopamine on the GABAergic transmission is action potential-dependent. Together, these findings reveal an indirect mechanism by which activation of D1-like receptors could inhibit the excitability of layer III pyramidal neurons in the MEC.

主题分类 醫藥衛生 > 基礎醫學
参考文献
  1. Gui, Z.H.,Liu, J.,Wang, Y.,Ali, U.,Wang, T.,Chen, L.(2011).Effects of chronic, systemic treatment with the dopamine receptor agonist R-apomorphine in partially lesioned rat model of Parkinson's disease: an electrophysiological study of substantia nigra dopamine neurons..Chinese J. Physiol.,54,96-104.
    連結:
  2. Liao, C.H.,Chen, S.Y.,Kuo, J.S.,Pang, C.Y.(2013).Reduction of motor disorder in 6-OHDA-induced severe parkinsonism rats by post treatment with granulocyte-colony stimulating factor.Chinese J. Physiol.,56,147-154.
    連結:
  3. Bandyopadhyay, S.,Hablitz, J.J.(2007).Dopaminergic modulation of local network activity in rat prefrontal cortex.J. Neurophysiol.,97,4120-4128.
  4. Berke, J.D.,Hyman, S.E.(2000).Addiction, dopamine, and the molecular mechanisms of memory.Neuron,25,515-532.
  5. Bjorklund, A.,Dunnett, S.B.(2007).Dopamine neuron systems in the brain: an update.Trends Neurosci,30,194-202.
  6. Canto, C.B.,Witter, M.P.(2012).Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex..Hippocampus,22,1277-1299.
  7. Cilz, N.I.,Kurada, L.,Hu, B.,Lei, S..Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-Type Ca2+ channels.Cereb. Cortex
  8. Deng, P.Y.,Lei, S.(2008).Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels.Mol. Cell. Neurosci.,39,273-284.
  9. Deng, P.Y.,Poudel, S.K.,Rojanathammanee, L.,Porter, J.E.,Lei, S.(2007).Serotonin inhibits neuronal excitability by activating twopore domain K+ channels in the entorhinal cortex..Mol. Pharmacol,72,208-218.
  10. Deng, P.Y.,Xiao, Z.,Yang, C.,Rojanathammanee, L.,Grisanti, L.,Watt, J.,Geiger, J.D.,Liu, R.,Porter, J.E.,Lei, S.(2009).GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels..Neuron,63,230-243.
  11. Fallon, J.H.(1981).Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex..J. Neurosci.,1,1361-1368.
  12. Fallon, J.H.,Moore, R.Y(1978).Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum.J. Comp. Neurol.,180,545-580.
  13. Floran, B.,Aceves, J.,Sierra, A.,Martinez-Fong, D.(1990).Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat..Neurosci. Lett.,116,136-140.
  14. Gloveli, T.,Schmitz, D.,Empson, R.M.,Dugladze, T.,Heinemann, U.(1997).Morphological and electrophysiological characterization of layer III cells of the medial entorhinal cortex of the rat..Neuroscience,77,629-648.
  15. Kuzhikandathil, E.V.,Oxford, G.S.(2002).Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl- 2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels.Mol. Pharmacol,62,119-126.
  16. Lei, S.,Deng, P.Y.,Porter, J.E.,Shin, H.S.(2007).Adrenergic facilitation of GABAergic transmission in rat entorhinal cortex..J. Neurophysiol.,98,2868-2877.
  17. Li, Y.,Fan, S.,Yan, J.,Li, B.,Chen, F.,Xia, J.X.,Yu, Z.P.,Hu, Z.A.(2011).Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors.Hippocampus,21,265-280.
  18. Lodge, D.J.,Grace, A.A.(2007).Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia..J. Neurosci.,27,11424-11430.
  19. Mayne, E.W.,Craig, M.T.,McBain, C.J. ,Paulsen, O.(2013).Dopamine suppresses persistent network activity via D1-like dopamine receptors in rat medial entorhinal cortex..Eur. J. Neurosci.,37,1242-1247.
  20. Melzer, S.,Michael, M.,Caputi, A.,Eliava, M.,Fuchs, E.C.,Whittington, M.A.,Monyer, H.(2012).Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex.Science,335,1506-1510.
  21. Monsma, F.J.,McVittie, L.D.,Gerfen, C.R.,Mahan, L.C.,Sibley, D.R.(1989).Multiple D2 dopamine receptors produced by alternative RNA splicing.Nature,342,926-929.
  22. Moser, E.I.,Kropff, E.,Moser, M.B.(2008).Place cells, grid cells, and the brain's spatial representation system..Annu. Rev. Neurosci.,31,69-89.
  23. Pastoll, H.,Solanka, L.,van-Rossum, M.C.,Nolan, M.F.(2013).Feedback inhibition enables theta-nested gamma oscillations and grid firing fields..Neuron,77,141-154.
  24. Pernia-Andrade, A.J.,Jonas, P.(2014).Theta-gamma-modulated synaptic currents in hippocampal granule cells in vivo define a mechanism for network oscillations.Neuron,81,140-152.
  25. Seamans, J.K.,Gorelova, N.,Durstewitz, D.,Yang, C.R.(2001).Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons..J. Neurosci.,21,3628-3638.
  26. Steffenach, H.A.,Witter, M.,Moser, M.B.,Moser, E.I.(2005).Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex.Neuron,45,301-313.
  27. Suh, J.,Rivest, A.J.,Nakashiba, T.,Tominaga, T.,Tonegawa, S.(2011).Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory..Science,334,1415-1420.
  28. Sulzer, D.(2007).Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease..Trends Neurosci,30,244-250.
  29. Towers, S.K.,Hestrin, S.(2008).D1-like dopamine receptor activation modulates GABAergic inhibition but not electrical coupling between neocortical fast-spiking interneurons.J. Neurosci.,28,2633-2641.
  30. Trevitt, T.,Carlson, B.,Correa, M.,Keene, A.,Morales, M.,Salamone, J.D.(2002).Interactions between dopamine D1 receptors and γ-aminobutyric acid mechanisms in substantia nigra pars reticulata of the rat: neurochemical and behavioral studies..Psychopharmacology,159,229-237.
  31. Van Cauter, T.,Camon, J.,Alvernhe, A.,Elduayen, C.,Sargolini, F.,Save, E.(2013).Distinct Roles of medial and lateral entorhinal cortex in spatial cognition..Cereb. Cortex,23,251-459.
  32. Van Strien, N.M.,Cappaert, N.L.M.,Witter, M.P.(2009).The anatomy of memory: an interactive overview of the parahippocampalhippocampal network.Nat. Rev. Neurosci,10,272-282.
  33. Varga, C.,Lee, S.Y.,Soltesz, I.(2010).Target-selective GABAergic control of entorhinal cortex output.Nat. Neurosci,13,822-824.
  34. Xiao, Z.,Deng, P.Y.,Yang, C.,Lei, S.(2009).Modulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats..J. Neurophysiol,102,659-669.